interferon-induced, double-stranded RNA-activated protein kinase isoform X1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: InterPro
• double-stranded RNA binding Source: Ensembl
• eukaryotic translation initiation factor 2alpha kinase activity Source: Ensembl
• identical protein binding Source: Ensembl

GO - Biological processⁱ

• activation of MAPKK activity Source: Ensembl
• cellular response to amino acid starvation Source: Ensembl
• endoplasmic reticulum unfolded protein response Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of osteoblast proliferation Source: Ensembl
• negative regulation of translation Source: Ensembl
• negative regulation of viral genome replication Source: Ensembl
• positive regulation of chemokine production Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: Ensembl
• positive regulation of NIK/NF-kappaB signaling Source: Ensembl
• positive regulation of stress-activated MAPK cascade Source: Ensembl
• protein autophosphorylation Source: Ensembl
• regulation of hematopoietic stem cell differentiation Source: Ensembl
• regulation of hematopoietic stem cell proliferation Source: Ensembl
• regulation of NLRP3 inflammasome complex assembly Source: Ensembl
• response to interferon-alpha Source: Ensembl
• response to virus Source: Ensembl
• translation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MASGRSPCFY IEELNKYQQK NTAVLKYREL SKTGPPHNLR FTYQVIIDGK 
        60         70         80         90        100
EFPKAEGRSK KEAKNAAAKL AFEIISKEQK AASPSSLQTG DPSEVPPIEN 
       110        120        130        140        150
YIGRVNTIAQ KKNLSVIYEE CESRDSGPDK FHYKCKIGQN EYGIGVGSTK 
       160        170        180        190        200
QEARQLAAKV AYEEIQSENL MKADASSGCF INVCGDVQSN SSATNTSASE 
       210        220        230        240        250
SQSENDFSTS EAESNDNSDA LDKSFQSPEN SSRNNPRKVK RSLAPRFDSP 
       260        270        280        290        300
VKREESMYTV DSRFSRDFTE VTPIDAGGFG QVFKAKHKID EKTYVIKRVK 
       310        320        330        340        350
YNNEKVEREV KALAMLDHAN IVHYHSCWDG LDYDPEQSIN SSRSKTRCLF 
       360        370        380        390        400
IQMEYCDKGT LERWIDSRRG KKQDKCLALV FFEQITEGVH YIHSKQLIHR 
       410        420        430        440        450
DLKPGNIFLV GMNQIKIGDF GLVTYLKNDD ARTSKQGTMR YMSPEQISCM 
       460        470        480        490        500
EDYGNEVDIF ALGLILAELL HICSTVSETV KLFEDLRDGT FSDVFDNKEK 
       510        520        530 
NLLQKLLSND PKKRPNTLEI LKTLKEWNNI AEKKKWNTC             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ