Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 8 (31 Jul 2019)
Sequence version 1 (12 Sep 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Delphinapterus leucas (Beluga whale)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3879S-adenosyl-L-methionineUniRule annotation1
Binding sitei3881S-adenosyl-L-methionineUniRule annotation1
Binding sitei3923S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3949ZincUniRule annotation1
Metal bindingi3997ZincUniRule annotation1
Binding sitei3998S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3999ZincUniRule annotation1
Metal bindingi4004ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1185 – 1233CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotationSAAS annotation (EC:2.1.1.43UniRule annotationSAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDelphinapterus leucas (Beluga whale)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9749 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiMonodontidaeDelphinapterus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248483 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1185 – 1233CXXC-typeInterPro annotationAdd BLAST49
Domaini1469 – 1520PHD-typeInterPro annotationAdd BLAST52
Domaini1517 – 1571PHD-typeInterPro annotationAdd BLAST55
Domaini1604 – 1665PHD-typeInterPro annotationAdd BLAST62
Domaini1741 – 1786BromoInterPro annotationAdd BLAST46
Domaini1908 – 2016PHD-typeInterPro annotationAdd BLAST109
Domaini2056 – 2112FYR N-terminalInterPro annotationAdd BLAST57
Domaini3706 – 3787FYR C-terminalInterPro annotationAdd BLAST82
Domaini3869 – 3985SETInterPro annotationAdd BLAST117
Domaini3993 – 4009Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65DisorderedSequence analysisAdd BLAST65
Regioni193 – 298DisorderedSequence analysisAdd BLAST106
Regioni361 – 382DisorderedSequence analysisAdd BLAST22
Regioni483 – 628DisorderedSequence analysisAdd BLAST146
Regioni751 – 983DisorderedSequence analysisAdd BLAST233
Regioni1076 – 1105DisorderedSequence analysisAdd BLAST30
Regioni1143 – 1204DisorderedSequence analysisAdd BLAST62
Regioni1238 – 1412DisorderedSequence analysisAdd BLAST175
Regioni1701 – 1742DisorderedSequence analysisAdd BLAST42
Regioni1844 – 1907DisorderedSequence analysisAdd BLAST64
Regioni2119 – 2171DisorderedSequence analysisAdd BLAST53
Regioni2184 – 2208DisorderedSequence analysisAdd BLAST25
Regioni2314 – 2366DisorderedSequence analysisAdd BLAST53
Regioni2399 – 2664DisorderedSequence analysisAdd BLAST266
Regioni2685 – 2717DisorderedSequence analysisAdd BLAST33
Regioni2754 – 2805DisorderedSequence analysisAdd BLAST52
Regioni2976 – 3099DisorderedSequence analysisAdd BLAST124
Regioni3207 – 3286DisorderedSequence analysisAdd BLAST80
Regioni3509 – 3647DisorderedSequence analysisAdd BLAST139
Regioni3659 – 3685DisorderedSequence analysisAdd BLAST27
Regioni3825 – 3848DisorderedSequence analysisAdd BLAST24
Regioni3946 – 3947S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili411 – 431Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi222 – 241PolarSequence analysisAdd BLAST20
Compositional biasi242 – 264PolyampholyteSequence analysisAdd BLAST23
Compositional biasi274 – 295PolyampholyteSequence analysisAdd BLAST22
Compositional biasi363 – 382PolyampholyteSequence analysisAdd BLAST20
Compositional biasi483 – 533PolarSequence analysisAdd BLAST51
Compositional biasi573 – 594PolarSequence analysisAdd BLAST22
Compositional biasi595 – 614Pro-richSequence analysisAdd BLAST20
Compositional biasi751 – 769PolarSequence analysisAdd BLAST19
Compositional biasi785 – 883PolarSequence analysisAdd BLAST99
Compositional biasi884 – 936PolyampholyteSequence analysisAdd BLAST53
Compositional biasi962 – 983PolarSequence analysisAdd BLAST22
Compositional biasi1084 – 1099PolarSequence analysisAdd BLAST16
Compositional biasi1272 – 1286PolarSequence analysisAdd BLAST15
Compositional biasi1287 – 1310PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1319 – 1340PolarSequence analysisAdd BLAST22
Compositional biasi1341 – 1355Pro-richSequence analysisAdd BLAST15
Compositional biasi1860 – 1885Pro-richSequence analysisAdd BLAST26
Compositional biasi2134 – 2156PolarSequence analysisAdd BLAST23
Compositional biasi2314 – 2358PolarSequence analysisAdd BLAST45
Compositional biasi2419 – 2433PolarSequence analysisAdd BLAST15
Compositional biasi2440 – 2456PolarSequence analysisAdd BLAST17
Compositional biasi2457 – 2483PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2566 – 2599PolarSequence analysisAdd BLAST34
Compositional biasi2609 – 2634PolarSequence analysisAdd BLAST26
Compositional biasi2762 – 2787PolarSequence analysisAdd BLAST26
Compositional biasi2788 – 2805PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2976 – 2992PolarSequence analysisAdd BLAST17
Compositional biasi3052 – 3099PolarSequence analysisAdd BLAST48
Compositional biasi3207 – 3224PolarSequence analysisAdd BLAST18
Compositional biasi3237 – 3263PolarSequence analysisAdd BLAST27
Compositional biasi3271 – 3286PolarSequence analysisAdd BLAST16
Compositional biasi3509 – 3568PolarSequence analysisAdd BLAST60
Compositional biasi3601 – 3625PolarSequence analysisAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1185 – 1233CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693 ePHD_KMT2A, 1 hit
cd15588 PHD1_KMT2A, 1 hit
cd15590 PHD2_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR037927 KMT2A
IPR041958 KMT2A_ePHD
IPR042023 KMT2A_PHD1
IPR042025 KMT2A_PHD2
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2 PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354 Methyltransferase_trithorax, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS50016 ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A2Y9M134-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPLVGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAAAA AAGSGGVGVP GGAAAASAAS SSSASSSSSS
110 120 130 140 150
SSSASSGPAL LRVGPGFDAA LQVSAAIGTN LRRFRAVFGE SGGGGGSGEL
160 170 180 190 200
TTQIPCSWRT KGLIHDKKTE PFRLLAWSWC LNDEQFLGFG SDEEVRVRSP
210 220 230 240 250
TRSPSVKTSP RKPRGRPRSG SDRNSALLSD PSVFSPLNKS ETKSGDKIKK
260 270 280 290 300
KDSKSIEKKR GRPPTFPGVK LKITHGKDIS ELPKGNKEDS LKKMKRTPSA
310 320 330 340 350
TFQQATKIKK LRAGKLSPLK SKFKTGKLQI GRKGVQIVRR RGRPPSTERI
360 370 380 390 400
KTPSGLLINS ELEKPQKVRK DKEGTPPLTK EDKTVVRQSP RRIKPVRIIP
410 420 430 440 450
SSKRTDATIA KQLLQRAKKG AQKKIEKEAA QLQGRKVKTQ VKNIRQFIMP
460 470 480 490 500
VVSAISSRII KTPRRFIEDE DYDPPIKIAR LESTPNSRFS ATSCGSSEKS
510 520 530 540 550
SAASQHSSQM SSDSSRSSSP SVDTSTDSQA SEEIQVLPEE RSDTPEVHTP
560 570 580 590 600
LPISQSPEND SNDRRSRRYS VSERSFGSRT TKKLSTLQSA PQQQTSSSPP
610 620 630 640 650
PPLLTPPPPL QPASSISDHT PWLMPPTIPL ASPFLPTSAA PMQGKRKSIL
660 670 680 690 700
REPTFRWTSL KHSRSEPQYF SSAKYAKEGL IRKPIFDNFR PPPLTPEDVG
710 720 730 740 750
FASGFSTSGT AASARLFSPL HSGTRFDMHK RSPLLRAPRF TPSEAHSRIF
760 770 780 790 800
ESVTLPSNRT SAGTSSSGVS NRKRKRKVFS PIRSEPRSPS HSMRTRSGRL
810 820 830 840 850
STSELSPLTP PSSVSSSLSI SVSPLATSAL NPTFTFPSHS LTQSGESAEK
860 870 880 890 900
NQRPRKQTSA PAEPFSSSSP TPLFPWFTPG SQTERGRNKD KAPEELSKER
910 920 930 940 950
DADKSMEKDK SRERDREREK ENKRESRKEK RKKGSEIQSS SALYPVGRVS
960 970 980 990 1000
KEKVVGEDVA TSSSAKKATG RKKSSSLDSG TDIASVTLGD TTAVKTKILI
1010 1020 1030 1040 1050
KKGRGNLEKT NLDLGPTAPS LEKEKTLCLS TPSSSTVKHS TSSIGSMLAQ
1060 1070 1080 1090 1100
ADKLPMTDKR VASLLKKAKA QLCKIEKSKS LKQTDQPKAQ GQESDSSETS
1110 1120 1130 1140 1150
VRGPRIKHVC RRAAVALGRK RAVFPDDMPT LSALPWEERE KILSSMGNDD
1160 1170 1180 1190 1200
KSSIAGSEDA EPLAPPIKPI KPVTRNKAPQ EPPVKKGRRS RRCGQCPGCQ
1210 1220 1230 1240 1250
VPEDCGVCTN CLDKPKFGGR NIKKQCCKMR KCQNLQWMPS KAYLQKQAKA
1260 1270 1280 1290 1300
VKKKEKKSKT SEKKESKESS VVKSLADSSQ KSTPSAREDP APKKSNSEPP
1310 1320 1330 1340 1350
PRKPPEDKSE EGNASTPGPE AKQVATPSSR KSSKQVSQPA PAVPLQPPST
1360 1370 1380 1390 1400
APPRKEVPKT TPSEPKKKQP PPPESGPEQS KQKKVAPRPS IPVKQKPKEK
1410 1420 1430 1440 1450
EKPPPVNKQE NAGTLNILSA LSNGNSSKQK VPADGVHRIR VDFKEDCEAE
1460 1470 1480 1490 1500
NVWEMGGLGI LTSVPITPRV VCFLCASSGH VEFVYCQVCC EPFHKFCLEE
1510 1520 1530 1540 1550
HERPLEDQLE NWCCRRCKFC HVCGRQHQAT KQLLECNKCR NSYHPECLGP
1560 1570 1580 1590 1600
NYPTKPTKKK KVWICTKCVR CKSCGSTTPG KGWDAQWSHD FSLCHDCAKL
1610 1620 1630 1640 1650
FAKGNFCPLC DKCYDDDDYE SKMMQCGKCD RWVHSKCENL SDEMYEILSN
1660 1670 1680 1690 1700
LPESVAYTCV NCTERHPAEW RLALEKELQI SLKQVLTALL NSRTTSHLLR
1710 1720 1730 1740 1750
YRQAAKPPDL NPETEESIPS RSSPEGPDPP VLTEVSKQED QQPLDLEGVK
1760 1770 1780 1790 1800
RKMDQGNYTS VLEFSDDIVK IIQAAINSDG GQPEIKKANS MVKSFFIRQM
1810 1820 1830 1840 1850
ERVFPWFSVK KSRFWEPNKV SSNSGMLPNA VLPPSLDHNY AQWQEREENS
1860 1870 1880 1890 1900
HTEQPPLMKK IIPAPKPKGP GEPDSPTPLH PPTPPILSTD RSREDSPELN
1910 1920 1930 1940 1950
PPPGIEDNRQ CALCLTYGDD SANDAGRLLY IGQNEWTHVN CALWSAEVFE
1960 1970 1980 1990 2000
DDDGSLKNVH MAVIRGKQLR CEFCQKPGAT VGCCLTSCTS NYHFMCSRAK
2010 2020 2030 2040 2050
NCVFLDDKKV YCQRHRDLIK GEVVPENGFE VFRRVFVDFE GISLRRKFLS
2060 2070 2080 2090 2100
GLEPENIHMM IGSMTIDCLG ILNDLSDCED KLFPIGYQCS RVYWSTTDAR
2110 2120 2130 2140 2150
KRCVYTCKIV ECRPPVVEPD INSTVEHDEN RTIAHSPTSF AEISPKESQN
2160 2170 2180 2190 2200
TAEIVSPPSP DRPPHSQTSG SCFYHVISKV PRIRTPSYSP TQRSPGCRPL
2210 2220 2230 2240 2250
PSAGSPTPTT HEIVTVGDPL LSSGLRSIGS RRHSTSSLSP QRSKLRIMSP
2260 2270 2280 2290 2300
MRTGSAYSRN SVSSVATVGT AADLESSAKA VDHVLGPLNS NTNLGQNTPT
2310 2320 2330 2340 2350
SSHLQRTVVT MGTKTSHFDG SSSSEMKHSS ASDSTSKSSS SKGEKTKMPS
2360 2370 2380 2390 2400
SKNSEGSAHN VAYPGLPKLA PQVHNATAGE LNVSKTGTFA ELSSVPFSSK
2410 2420 2430 2440 2450
EALPFPPLHL RGQRNDRDQQ TDSNQSANSP PDEDTEVKTL KLSGVSNRSS
2460 2470 2480 2490 2500
IINEHVGSSS RDRRQKGKKS SKEMFKEKHS SKSFLEPGQV ATGEEGNLKP
2510 2520 2530 2540 2550
EFVDEVLPPD FMGQRPCNNV SSDKTGDKVH SIPGVPKAPS MQVEGSAKEL
2560 2570 2580 2590 2600
QTPRKRTVKV TLTPLKMEGE SQSKNTLKES SPLSPLQIES ASPTEPVSTS
2610 2620 2630 2640 2650
EGPGDGPVAQ ASPNNTSSQD SQSNNYQNLP VQDRQDRNLM LPDGPKPQED
2660 2670 2680 2690 2700
GSFKRRYPRR SARARSNMFF GLTPLYGVRS YGEEDIPFYS SSTGKKRGKR
2710 2720 2730 2740 2750
SAEGQVDGAD DLSTSDEDDL YYYNFTRTVI SSGGEERLTP HNLFREEEQC
2760 2770 2780 2790 2800
DLPKISQLDG VDDGTESDTS VTATTRKGSQ IPKRNSKENG TENLKMDRPE
2810 2820 2830 2840 2850
DTGEKEHVIK SSVGHKNEPK MDNCHAVSRV KTQGQDSLEA QLSSLESSRR
2860 2870 2880 2890 2900
VHTSTPSDKN LLDTYNTELL KSDSDNNNSD DCGNILPSDI MDFVLKNTPS
2910 2920 2930 2940 2950
MQALGESPES SSSELLNLGE GLGLDSNREK DMGLFEVFSQ QLPTTEAVDS
2960 2970 2980 2990 3000
SVSSSISAEE QFELPLELPS DLSVLTTRSP TVPSQNPSRL AVISDSGEKR
3010 3020 3030 3040 3050
GTIPEKSVAS SEGDSSLLSP GVDPSPEGHM TPDHFIQGHM DADHISSPPC
3060 3070 3080 3090 3100
GSVEQGHGNN QDLTRNSSTP GLQVPVSPTV PIQNQKYVPN STDSPGPSQI
3110 3120 3130 3140 3150
SNAAVQTTPP HLKPATEKLI VVNQNMQPLY VLQTLPNGVT QKIQLTSSVS
3160 3170 3180 3190 3200
SAPSVMETNT SVLGPMGSGL TLTTGLSPSL PTSQALFPPA SKGLLPMPHH
3210 3220 3230 3240 3250
QHLHSFPAAT QSSFPPNINS PPSGLLIGVQ PPPDPQLLVS EASQRTDLST
3260 3270 3280 3290 3300
TVATPSSGLK KRPISRLQTR KNKKLAPSST PSNIAPSDVV SNMTLINFTP
3310 3320 3330 3340 3350
SQLPNHPNLL DLGSLNTSSH RTVPNIIKRS KSGIMYFEQA PLLPQSVGGT
3360 3370 3380 3390 3400
AAPAAGAATM SQDTGHLTSG PVSGLASGSS VLNVVSMQTT TAPTSSASVP
3410 3420 3430 3440 3450
GHVALTNPRL LGSPDIGSIS NLLIKASQQS LGIQDQPVAL PPSSGMFPQL
3460 3470 3480 3490 3500
GTSQTPATAA MTAASSICVL PSTQTAGITA ASPSGEAEEH YQLQHVNQLL
3510 3520 3530 3540 3550
ASKTGILSSQ QDLDSAPGTQ GSNFTQTVDA PNSMGLEQNK ALSSAMQASS
3560 3570 3580 3590 3600
TSPGGSPSSG QQSASPSVPG PMKPKPKIKR IQLPLDKGGG KKHKVSHLRT
3610 3620 3630 3640 3650
SSSEAHIPDQ EANTTPLTSV TGAPGAEAEQ QDIANVEQSP QKECGQPAGQ
3660 3670 3680 3690 3700
VAVLPEIQTT QNPADEQENS EPKTAEEEES NFSSPLMLWL QQEQKRKESI
3710 3720 3730 3740 3750
AEKKPKKGLV FEISSDDGFQ ICAESIEDAW KSLTDKVQEA RSNARLKQLS
3760 3770 3780 3790 3800
FAGVNGLRML GILHDAVVFL IEQLSGAKHC RNYKFRFHKP EEANEPPLNP
3810 3820 3830 3840 3850
HGSARAEVHL RKSAFDMFNF LASKHRQPPE YNPNDEEEEE VQLKSARRAT
3860 3870 3880 3890 3900
SMDLPMPMRF RHLKKTSKEA VGVYRSPIHG RGLFCKRNID AGEMVIEYAG
3910 3920 3930 3940 3950
NVIRSIQTDK REKYYDSKGI GCYMFRIDDS EVVDATMHGN AARFINHSCE
3960 3970 3980 3990 4000
PNCYSRVINI DGQKHIVIFA MRKIYRGEEL TYDYKFPIED ASNKLPCNCG

AKKCRKFLN
Length:4,009
Mass (Da):435,673
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB05FCD48E254EB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9MBG2A0A2Y9MBG2_DELLE
Histone-lysine N-methyltransferase
KMT2A
4,012Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9LZA9A0A2Y9LZA9_DELLE
Histone-lysine N-methyltransferase
KMT2A
4,011Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9M6J8A0A2Y9M6J8_DELLE
Histone-lysine N-methyltransferase
KMT2A
3,979Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9MBG7A0A2Y9MBG7_DELLE
Histone-lysine N-methyltransferase
KMT2A
3,976Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9LYH1A0A2Y9LYH1_DELLE
Histone-lysine N-methyltransferase
KMT2A
3,281Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9LZB6A0A2Y9LZB6_DELLE
Histone-lysine N-methyltransferase
KMT2A
3,173Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9M141A0A2Y9M141_DELLE
Histone-lysine N-methyltransferase
KMT2A
3,140Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_022414766.1, XM_022559058.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_022414766.1, XM_022559058.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd15693 ePHD_KMT2A, 1 hit
cd15588 PHD1_KMT2A, 1 hit
cd15590 PHD2_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR037927 KMT2A
IPR041958 KMT2A_ePHD
IPR042023 KMT2A_PHD1
IPR042025 KMT2A_PHD2
IPR016569 MeTrfase_trithorax
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2 PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00628 PHD, 2 hits
PF00856 SET, 1 hit
PF02008 zf-CXXC, 1 hit
PIRSFiPIRSF010354 Methyltransferase_trithorax, 2 hits
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00249 PHD, 4 hits
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit
PS51058 ZF_CXXC, 1 hit
PS50016 ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9M134_DELLE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9M134
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: July 31, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again