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Entry version 13 (19 Jan 2022)
Sequence version 1 (12 Sep 2018)
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Protein
Submitted name:

nesprin-1-like

Gene

LOC111158654

Organism
Enhydra lutris kenyoni
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nesprin-1-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC111158654Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnhydra lutris kenyoniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri391180 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeLutrinaeEnhydra
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248482 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
391180.A0A2Y9KTR7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 134Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini178 – 283Calponin-homology (CH)InterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili310 – 330Sequence analysisAdd BLAST21
Coiled coili418 – 438Sequence analysisAdd BLAST21
Coiled coili608 – 632Sequence analysisAdd BLAST25
Coiled coili758 – 778Sequence analysisAdd BLAST21
Coiled coili912 – 932Sequence analysisAdd BLAST21
Coiled coili1297 – 1324Sequence analysisAdd BLAST28
Coiled coili1396 – 1430Sequence analysisAdd BLAST35
Coiled coili1537 – 1557Sequence analysisAdd BLAST21
Coiled coili1963 – 1990Sequence analysisAdd BLAST28
Coiled coili1997 – 2017Sequence analysisAdd BLAST21
Coiled coili2067 – 2087Sequence analysisAdd BLAST21
Coiled coili2220 – 2247Sequence analysisAdd BLAST28
Coiled coili2257 – 2277Sequence analysisAdd BLAST21
Coiled coili2325 – 2352Sequence analysisAdd BLAST28
Coiled coili2465 – 2485Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2Y9KTR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRTASRS PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPLAV
60 70 80 90 100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE
110 120 130 140 150
GRKIKLVNIN STDIADGRPS IVLGLMWTII LYFQIEELTS NLPQLQSLSG
160 170 180 190 200
STSSVDSMVS AETASPPSKR KVATKIQGNA KKALLKWVQY TVAKQTGIEV
210 220 230 240 250
KDFGRSWRSG VAFHSIIHAI RPELVDLERV KGRPNRENLA EAFTVAETEL
260 270 280 290 300
GIPRLLDPED VDVDKPDEKS IMTYVAQFLK HYPDIHNTGT DGQENDREDR
310 320 330 340 350
LILKETKVWI EQFERDLTRA QMMESNLQDK YQSFKHFRVQ YELKRKQIER
360 370 380 390 400
LIQPVHRNGK LSLDQALVKQ SWDRVSSRLF DWHIQLDKSL PAPLGTIGAW
410 420 430 440 450
LYRAEVALRE EITIQQVHEE TANTIQRKRE QHKDLLQNTD AHKRAFHDIY
460 470 480 490 500
QTRSVNGIPV PPDQLEDMAE RFHFVSSTSE LHLMKMEFLE LKYRLLSLLV
510 520 530 540 550
LAESKLKSWI IKYGRRESVE LLLQNYISFI ENTKFFEQYE VTYQILKQTA
560 570 580 590 600
EMYVQADGSV EEAENVMKFM NETTAQWRNL SVEVRSVRSM LEEVIANWDR
610 620 630 640 650
YGNTVASLQA WLEDAEKMLN QSEHAKKDFF RNLPHWIQQH AAMNDAGNFL
660 670 680 690 700
IETCDEMVSR DLKQQLLLLN GRWRELFMEV KQYARADEMD RMKKEYTDCV
710 720 730 740 750
TALSDFATEA LKKMSEPLEV SFLNVKLLIQ DLEDIEQRVP VMDAQYKMIT
760 770 780 790 800
KTAHLITKES SQEEANEMFA TMSRLKEQLT KVKEGHSPLL YESRQLSVPL
810 820 830 840 850
EELEKQMTFF YESLGKINEI LTVLEHEAQS SALFKQKQQE LSACQESCKK
860 870 880 890 900
TMTHIEKGSQ NVQKFVTLSS VLKHFDETKL HRQIADAHGA FQNMVKKIGD
910 920 930 940 950
WKKHVETNSR LMKKFEESRA ELEKVLRMAQ EGLEEKGNPE DLLKRHTEFF
960 970 980 990 1000
SQLDQRVLNA FLKACDELTD ILPEQEQQGL QEAVRKLHKQ WKDLQGEAPY
1010 1020 1030 1040 1050
HLLHLKIGVE KNRFLASVEE CRTELDRETK LVPQEGSEKI IKEHRIFFSD
1060 1070 1080 1090 1100
KGPHHLCEKR LQLIEELCLK LPVRDPVRNT PETCHATLRE LRAAISATYM
1110 1120 1130 1140 1150
KLVEDPDKWK DYTSRISEFS SWITAKETQL KAFKSKPFDT ANHGEVKRAV
1160 1170 1180 1190 1200
EEIRNGVTTK GETLNWLKSR LKILIEVSSE NEAQKQGDEL AKLSGSFKAL
1210 1220 1230 1240 1250
AALLSEVEKM LNNFGDCVQY KEMVQSSLED LISGSKEVQE QAEKILDTEN
1260 1270 1280 1290 1300
LFEAQQLLLH HQQKTKRISA KKRDVQQQIA QAQQGEGGLP GQAREELRKL
1310 1320 1330 1340 1350
ESTLDNMEHS REKQERRIQV TLRKWERFET NKETVVRYLF QTGSSHERFL
1360 1370 1380 1390 1400
SFSSLESLSS ELEQTKEFSK RTESIAVQAE NLVKEASEIP LGPKNKQLLQ
1410 1420 1430 1440 1450
QQAKSIKEQV KKLEDTLEED IKTMEMVKNK WDHFGNNFET LSVWITEKEK
1460 1470 1480 1490 1500
ELNALETSSS TMDKQIHQIK VTIQEIESKI SSITELEEAA QSFAQFVTTG
1510 1520 1530 1540 1550
ESARIKAKLT QIRRYWEELR EHAQCLEGTI LGHLSQQQKF EENLRKIQKS
1560 1570 1580 1590 1600
VSEFEDKLAD PLKICSSATE TYKVLQEHMD LCQALEALSS VVATTSASAQ
1610 1620 1630 1640 1650
KVANRGSSVQ EAVALQQRYE ETWTRAKERQ TALETLLAHW QRLEKELSTF
1660 1670 1680 1690 1700
LTWLERCEEI ASSPEMDISA DRVKVESELQ SIQALQNEVV SRASIYSSLL
1710 1720 1730 1740 1750
QLKESLFSVA SKDDVKTMKV HLEQLDERWR DLPQIINKRI TFLQSAVAEH
1760 1770 1780 1790 1800
QQFDELLLSF SVWIKLFLGE LQTTSEISIT DHQAAFTRHK DHTAEVESKK
1810 1820 1830 1840 1850
GELHSLRDHL VKLGALGRAE NLPLLQGKAE DCFQLFEEAS QVVERRQLAL
1860 1870 1880 1890 1900
SQLAEFLQSH ASLSGVLHRL RHTVETTESM NRKQTDLLEK DLNHAIQDAK
1910 1920 1930 1940 1950
ALESAAISLD SVLAKAQYHL KSGNSEQRTS CRTTTDHLCS ELERIQNLLG
1960 1970 1980 1990 2000
MKQSEADALA VLKKAFQDQK EELLRSIEDI EERTDKERLK ELTRQALQQR
2010 2020 2030 2040 2050
LRVFNQLEDE LNSHEHELCW LKDKAKQIAQ KDVAFASEVD REVNRLEVTW
2060 2070 2080 2090 2100
DDTKKLIHEN QGQCCGLIDL MREYQNLKSA VSKVLENASN VIATRNTIKD
2110 2120 2130 2140 2150
QEDLRWALSK HETVKNEMCN KQKELDNFTS KGKQLLSELK KIHSSDFILV
2160 2170 2180 2190 2200
KTDMESTVDR WLDMSEKIEE NMDRLRVSLT IWADVLSSKE EIDGWSNSSV
2210 2220 2230 2240 2250
PQLAESISHL NNSVRAEEVL KEFESEVKNK ALRLEELHCK VNDLKELTKN
2260 2270 2280 2290 2300
PETPPDLQFI EADLRQKLEH AKEITEEAKG TLKDFTAQST QVEKFINDMT
2310 2320 2330 2340 2350
SWLAKVEESL MNCAQTKTWE GLRKVKEIQK ELQSQQSNIS STQENLNSLC
2360 2370 2380 2390 2400
RKYHSIELES LGSALTGLIK NHEAVSQLCS KTQASLQDSL EKHFSESMQE
2410 2420 2430 2440 2450
FQEWFSGIKA AAKESSDRTG DSKVLEAKLH DLQNILDSIS DGQSKLDAVT
2460 2470 2480 2490 2500
QEGQTLYAHV SKQIVSSIQE QITKANEEFQ AFLKQCLRDK QALQDCALEL
2510 2520 2530 2540 2550
GSFEDQHRKL NLWIHEMDER LSTENLGESK QHIPEKKNEV HKVEMFLGEL
2560 2570 2580 2590 2600
LAARESLDKL SQRGQLLSEE GHGAGKEGRL CSQLLTNYQN LLRMTKERLR
2610 2620 2630 2640 2650
SCQMALQEHE ALEEALQSMW SWVKGIQDRL AAAESTVGSK DTLEKRLLQI
2660 2670 2680 2690 2700
QDILLMKGEG EVKLNMAIGK GEQALRSSNK QGQKVIQTQL QTLKDVWADI
2710 2720 2730 2740 2750
MSSSVHAQST LEAVIGKWND YLEWKHQLEQ WLESVDQKVE QPLQLQPGLK
2760 2770 2780 2790 2800
EKFSLLDHFQ SVVSEAEEHA RALQSLASKS RELYQKTEDE SFKEAAQEEL
2810 2820 2830 2840 2850
KTQFNDIITV SKEKMRKVEE IVKDHLMYLD AVQEFTDWLH SAKEELHRWS
2860 2870 2880 2890 2900
DMSGDSSATQ KKLSKIKELM DSREIGADRL SRVESLAPAV KQNTSASGCE
2910 2920 2930 2940 2950
LVDTEMQALR ADWKQWEDSV LRTQTSLENL VSQMALSEQE FSGQVTHLEQ
2960 2970 2980 2990 3000
ALGQFSALLT TWAQQLALLE GKNTDQEIVE CWQKGQEILN ALQKSEPKTE
3010 3020 3030
DLKSQLNELC RFSRDLSTYS GRVSGLIKEY NW
Length:3,032
Mass (Da):348,729
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62214B8167D9BFBE
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_022376553.1, XM_022520845.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
elk:111158654

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_022376553.1, XM_022520845.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi391180.A0A2Y9KTR7

Genome annotation databases

KEGGielk:111158654

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 3 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 11 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9KTR7_ENHLU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9KTR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: January 19, 2022
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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