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Protein

Orexin

Gene

LOC111151706

Organism
Enhydra lutris kenyoni
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested.UniRule annotation

Keywordsi

Molecular functionNeuropeptideUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
OrexinUniRule annotation
Alternative name(s):
HypocretinUniRule annotation
Gene namesi
Name:LOC111151706Imported
OrganismiEnhydra lutris kenyoniImported
Taxonomic identifieri391180 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeLutrinaeEnhydra
Proteomesi
  • UP000248482 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_501588309033 – 131OrexinSequence analysisAdd BLAST99

Family & Domainsi

Sequence similaritiesi

Belongs to the orexin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR001704 Orexin
PANTHERiPTHR15173 PTHR15173, 1 hit
PfamiView protein in Pfam
PF02072 Orexin, 1 hit
PIRSFiPIRSF037824 Orexin, 1 hit
PRINTSiPR01091 OREXINPP

Sequencei

Sequence statusi: Complete.

A0A2Y9JWS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPPSMKVPW AAVTLLLLLL LPPALLSPGA AAQPLPDCCR QKTCSCRLYE
60 70 80 90 100
LLHGAGNHAA GILTLGKRRP GPPGLQGRLQ RLLQASGNHA AGILTMGRRA
110 120 130
GAEPAPRPCP GRRCSAAAAA PSAAPGGRSG V
Length:131
Mass (Da):13,335
Last modified:September 12, 2018 - v1
Checksum:iC96A1191D7EB7FA7
GO

Sequence databases

RefSeqiXP_022365567.1, XM_022509859.1

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_022365567.1, XM_022509859.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR001704 Orexin
PANTHERiPTHR15173 PTHR15173, 1 hit
PfamiView protein in Pfam
PF02072 Orexin, 1 hit
PIRSFiPIRSF037824 Orexin, 1 hit
PRINTSiPR01091 OREXINPP
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2Y9JWS1_ENHLU
AccessioniPrimary (citable) accession number: A0A2Y9JWS1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: October 10, 2018
This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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