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Entry version 15 (02 Jun 2021)
Sequence version 1 (12 Sep 2018)
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Protein
Submitted name:

ras GTPase-activating protein nGAP isoform X1

Gene

LOC111150925

Organism
Enhydra lutris kenyoni
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ras GTPase-activating protein nGAP isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC111150925Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnhydra lutris kenyoniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri391180 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeLutrinaeEnhydra
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248482 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini207 – 438PHInterPro annotationAdd BLAST232
Domaini607 – 799Ras-GAPInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66DisorderedSequence analysisAdd BLAST66
Regioni193 – 212DisorderedSequence analysisAdd BLAST20
Regioni245 – 315DisorderedSequence analysisAdd BLAST71
Regioni1029 – 1062DisorderedSequence analysisAdd BLAST34
Regioni1077 – 1179DisorderedSequence analysisAdd BLAST103
Regioni1191 – 1234DisorderedSequence analysisAdd BLAST44
Regioni1395 – 1419DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1246 – 1332Sequence analysisAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20Polar residuesSequence analysisAdd BLAST20
Compositional biasi248 – 262Polar residuesSequence analysisAdd BLAST15
Compositional biasi294 – 315Polar residuesSequence analysisAdd BLAST22
Compositional biasi1081 – 1115Polar residuesSequence analysisAdd BLAST35
Compositional biasi1116 – 1134Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1191 – 1233Polar residuesSequence analysisAdd BLAST43

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR021887, DUF3498
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot

The PANTHER Classification System

More...
PANTHERi
PTHR10194, PTHR10194, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF12004, DUF3498, 1 hit
PF00616, RasGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A2Y9JU83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESWKMSIFK RQTSPCPPSY RRSLSEPADA NSEIGASLKS YPWRGPVRSK
60 70 80 90 100
RKKNEHAASS LGKPLGAYRW QTHPSYRWKG GKRERLETNK KDLDEPQQKV
110 120 130 140 150
LSKMVGNKAS SSAKEVLGTS TEKLNLVNTR SLRVPFTRSI SEPEPRCNIR
160 170 180 190 200
FVRPWPTSGR SEESEQQGYF IRGIFSTLSN GFSRMLSLKG ESTNESVRED
210 220 230 240 250
VKGPPTHRLS CGQSPYTETT TWERKYCILT DSQLVLLNKE KEIPVEGGQE
260 270 280 290 300
QQTDSTKGRC LRRTVSVPSE GQFPEYPPEG ATKLEVPAER SPRRRSISGT
310 320 330 340 350
STSEKPNSMD TVNTSPFKVP GFFSKRLKGS IKRTKSQSKL DRNTSFRLPS
360 370 380 390 400
LRNADDRARG LPKLKESRSH ESLLSPCSAV ECLDLGRGEP VSVKPLHSSI
410 420 430 440 450
LGQDFCFEVT YLSGSKCFSC NSASERDKWM ENLRRTVQPN KDNCRRAENV
460 470 480 490 500
LRLWIIEAKD LAPKKKYFCE LCLDDTLFAR TTSKTKADNI FWGEHFEFYS
510 520 530 540 550
LPPLHSITVH IYKDVEKKKK KDKNNYVGLV NIPTASVTGR QFVEKWYPVS
560 570 580 590 600
TPTPNKGKTG GPSIRIKSRF QTITILPMEQ YKEFAEFVTS NYTMLCSVLE
610 620 630 640 650
PVISVRNKEE LACALVHILQ STGRAKDFLT DLVMSEVDRC GEHDVLIFRE
660 670 680 690 700
NTIATKSIEE YLKLVGQQYL HDALGEFIKA LYESDENCEV DPSKCSSSEL
710 720 730 740 750
IDHQSNLKMC CELAFCKIIN SYCVFPRELK EVFASWKQQC LTRGKQDISE
760 770 780 790 800
RLISASLFLR FLCPAIMSPS LFNLMQEYPD DRTSRTLTLI AKVIQNLANF
810 820 830 840 850
AKFGNKEEYM AFMNDFLEHE WGGMKRFLLE ISNPDTISNT PGFDGYIDLG
860 870 880 890 900
RELSVLHSLL WEVVSQLDKG ENSFLQATVA KLGPLPRVLA DITKSLTNPT
910 920 930 940 950
PIQQQLRRFT EHNSSPNVSG SLSSGLQKIF EDPTDSDLHK LKSPSQDNTD
960 970 980 990 1000
SYFRGKTLLL VQQASSQSMT YSEKDEKESS LPNGRSISLM DLQDPHAAQV
1010 1020 1030 1040 1050
EHASVMLDVP VRLTGSQLSI TQVASIKQLR ETQSTPQSAP QVRRPLHPAL
1060 1070 1080 1090 1100
NQPGSLQPLS FQNPVYHLNN PIPAMPKASV DSSLENLSTA SSRSQSNSED
1110 1120 1130 1140 1150
FKLSGPSNSS MEDFTKRSTQ SEDFSRRHTV PDRHVPLALP RQNSTGQAHI
1160 1170 1180 1190 1200
RKMDQAGLGA RAKAPPSLPH SASLRSTGSM SVASAALVAE PVQNGSRSQQ
1210 1220 1230 1240 1250
QSSSSRESPV PKVRAIQRQQ TQQVQSPVDS ATMSPVERTA AWVLNNGQYE
1260 1270 1280 1290 1300
EDVEETEQNQ DESKHAEKYE QEITKLKERL RVSSRRLEED ERRLLVQEQQ
1310 1320 1330 1340 1350
MQKLLLEYKA RLEDSEERLR RQQEEKDSQM KSIISRLMAV EEELKKDHAE
1360 1370 1380 1390 1400
MQAVIDAKQK IIDAQEKRIV SLDSANTRLM SALTQVKERY SMQVRNGLSP
1410
TNPTKLSITE NGEFKNSSC
Length:1,419
Mass (Da):160,162
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9FE63CF51A1BF86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9JTD9A0A2Y9JTD9_ENHLU
ras GTPase-activating protein nGAP ...
LOC111150925
1,412Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9JTL4A0A2Y9JTL4_ENHLU
ras GTPase-activating protein nGAP ...
LOC111150925
1,287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9JXR7A0A2Y9JXR7_ENHLU
ras GTPase-activating protein nGAP ...
LOC111150925
1,280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_022364321.1, XM_022508613.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
elk:111150925

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_022364321.1, XM_022508613.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGielk:111150925

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR021887, DUF3498
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
PANTHERiPTHR10194, PTHR10194, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF12004, DUF3498, 1 hit
PF00616, RasGAP, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9JU83_ENHLU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9JU83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: June 2, 2021
This is version 15 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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