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UniProtKB - A0A2Y9IRQ9 (A0A2Y9IRQ9_ENHLU)

Entry version 13 (10 Feb 2021)
Sequence version 1 (12 Sep 2018)
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Protein
Submitted name:

LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas

Gene

LOC111141614

Organism
Enhydra lutris kenyoni
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducerARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(S) subunit alpha isoforms XLasImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC111141614Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnhydra lutris kenyoniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri391180 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Mustelidae › Lutrinae › Enhydra ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248482 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    MembraneARBA annotation

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 257DisorderedSequence analysisAdd BLAST257
    Regioni277 – 548DisorderedSequence analysisAdd BLAST272
    Regioni560 – 612DisorderedSequence analysisAdd BLAST53
    Regioni651 – 678DisorderedSequence analysisAdd BLAST28
    Regioni692 – 717DisorderedSequence analysisAdd BLAST26

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili717 – 737Sequence analysisAdd BLAST21

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi342 – 361PolyampholyteSequence analysisAdd BLAST20
    Compositional biasi500 – 528PolyampholyteSequence analysisAdd BLAST29
    Compositional biasi534 – 548BasicSequence analysisAdd BLAST15
    Compositional biasi578 – 612PolyampholyteSequence analysisAdd BLAST35
    Compositional biasi703 – 717PolyampholyteSequence analysisAdd BLAST15

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the G-alpha family. G(s) subfamily.ARBA annotation

    Keywords - Domaini

    Coiled coilSequence analysis

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd00066, G-alpha, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.400.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR000367, Gprotein_alpha_S
    IPR001019, Gprotein_alpha_su
    IPR011025, GproteinA_insert
    IPR027417, P-loop_NTPase

    The PANTHER Classification System

    More...    PANTHERi    		PTHR10218, PTHR10218, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00503, G-alpha, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00318, GPROTEINA
    PR00443, GPROTEINAS

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00275, G_alpha, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF47895, SSF47895, 1 hit
    SSF52540, SSF52540, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS51882, G_ALPHA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A2Y9IRQ9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGVRNCLDGN NMSGQRDIPL ELGEQSEQPS LEAPGAAAPS PGPGAAEEME 
            60         70         80         90        100
    TEPPHSEPVP LEIEGEACGP PEVSRPNFQD VGEAIEEAGA HGGYSPPPEE 
           110        120        130        140        150
    AMPFEVEQPC SGGFWPTPEQ PGDTAGACAG LEVFGPTLVE PGAFGDARPG 
           160        170        180        190        200
    LGGYSPPPEE AMPFEFEQPA QGGGSQPPLQ VSDLAPGGPG AGVFSTPPQE 
           210        220        230        240        250
    PQALRPANAD FGGDRSPPPE EAMPFEFDGA AFGDDSPPPG LPRAIPQIDG 
           260        270        280        290        300
    GGGSGQSAAA AVSSAVLLAP AANEPPLWVP AAIGSPSREA VRSPPHLAGD 
           310        320        330        340        350
    SPPMEISGPP LEIGSAPVGV DDAPVNMDSP PIALDGPPIE VSRAPVKRER 
           360        370        380        390        400
    AEGERPPVEG EAAEMEGGSA AAAAEGGKVP SPGDGAPDAG AKPAAPAAGA 
           410        420        430        440        450
    ATAAPDTPAA GAAAPAAPDA PAAGAAPAAP DAPAAPAAPA APAAPAAPAA 
           460        470        480        490        500
    GAAAPAARAA PAAPASGARP KLRFLRPPSP EIQAADPPTP QPTRAFAWRG 
           510        520        530        540        550
    RSGRSRDDDE GSVSSDDHSS DESDDGTSGC RRWLQPRRNR RRRKPRRNLL 
           560        570        580        590        600
    RNFLMQAFGG CFGRSESPQP KASHSPKVKK IPLAEKRRQM RKEALEKRAQ 
           610        620        630        640        650
    KRAEKKRSKL IDKQLQEEKM GYMCTHRLLL LGRKVVPSNT EGRFRLDKPA 
           660        670        680        690        700
    SATVRXPPVP GWGPARKKGA SGAGESGKST IVKQMRILHV NGFNGEGGEE 
           710        720        730        740        750
    DPQAARSNSD GEKATKVQDI KNNLKEAIET IVAAMSNLVP PVELANPENQ 
           760        770        780        790        800
    FRVDYILSVM NVPDFDFPPE FYEHAKALWE DEGVRACYER SNEYQLIDCA 
           810        820        830        840        850
    QYFLDKIDVI KQADYVPSDQ DLLRCRVLTS GIFETKFQVD KVNFHMFDVG 
           860        870        880        890        900
    GQRDERRKWI QCFNDVTAII FVVASSSYNM VIREDNQTNR LQEALNLFKS 
           910        920        930        940        950
    IWNNRWLRTI SVILFLNKQD LLAEKVLAGK SKIEDYFPEF ARYTTPEDAT 
           960        970        980        990       1000
    PEPGEDPRVT RAKYFIRDEF LRISTASGDG RHYCYPHFTC AVDTENIRRV 
          1010 
    FNDCRDIIQR MHLRQYELL
    Length:1,019
    Mass (Da):108,742
    Last modified:September 12, 2018 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EE1A2569BC0155A
    GO

    Sequence databases

    NCBI Reference Sequences

    More...    RefSeqi    		XP_022350014.1, XM_022494306.1

    Genome annotation databases

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		elk:111141614

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    RefSeqiXP_022350014.1, XM_022494306.1

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Genome annotation databases

    KEGGielk:111141614

    Family and domain databases

    CDDicd00066, G-alpha, 1 hit
    Gene3Di1.10.400.10, 1 hit
    InterProiView protein in InterPro
    IPR000367, Gprotein_alpha_S
    IPR001019, Gprotein_alpha_su
    IPR011025, GproteinA_insert
    IPR027417, P-loop_NTPase
    PANTHERiPTHR10218, PTHR10218, 1 hit
    PfamiView protein in Pfam
    PF00503, G-alpha, 1 hit
    PRINTSiPR00318, GPROTEINA
    PR00443, GPROTEINAS
    SMARTiView protein in SMART
    SM00275, G_alpha, 1 hit
    SUPFAMiSSF47895, SSF47895, 1 hit
    SSF52540, SSF52540, 1 hit
    PROSITEiView protein in PROSITE
    PS51882, G_ALPHA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9IRQ9_ENHLU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9IRQ9
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
    Last sequence update: September 12, 2018
    Last modified: February 10, 2021
    This is version 13 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteomeImported
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