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UniProtKB - A0A2Y9HHN6 (A0A2Y9HHN6_NEOSC)

Entry version 12 (19 Jan 2022)
Sequence version 1 (12 Sep 2018)
Previous versions | rss
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Protein
Submitted name:

nesprin-1-like

Gene

LOC110583187

Organism
Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nesprin-1-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC110583187Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29088 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Phocidae › Neomonachus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248481 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		29088.A0A2Y9HHN6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 134Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini178 – 283Calponin-homology (CH)InterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili310 – 330Sequence analysisAdd BLAST21
Coiled coili418 – 438Sequence analysisAdd BLAST21
Coiled coili608 – 632Sequence analysisAdd BLAST25
Coiled coili758 – 778Sequence analysisAdd BLAST21
Coiled coili912 – 932Sequence analysisAdd BLAST21
Coiled coili1297 – 1324Sequence analysisAdd BLAST28
Coiled coili1396 – 1430Sequence analysisAdd BLAST35
Coiled coili1469 – 1489Sequence analysisAdd BLAST21
Coiled coili1537 – 1557Sequence analysisAdd BLAST21
Coiled coili1789 – 1816Sequence analysisAdd BLAST28
Coiled coili1963 – 1990Sequence analysisAdd BLAST28
Coiled coili1997 – 2017Sequence analysisAdd BLAST21
Coiled coili2220 – 2247Sequence analysisAdd BLAST28
Coiled coili2257 – 2277Sequence analysisAdd BLAST21
Coiled coili2325 – 2352Sequence analysisAdd BLAST28
Coiled coili2465 – 2485Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2Y9HHN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRMASRS PRDIANVMQR LQDEQEIVQK RTFTKWINSH LSKRKPPLVI 
        60         70         80         90        100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE 
       110        120        130        140        150
GRKIKLVNIN STDIADGRPS IVLGLVWTII LYFQIEELTS NLPQLQSLSG 
       160        170        180        190        200
STSSVDSMVS AETASPPSKR KVATKLQGNA KKALLKWVQY TVAKQTGIEV 
       210        220        230        240        250
KDFGRSWRSG VAFHSIIHAI RPELVDLERV KGRPNRENLE EAFTIAETEL 
       260        270        280        290        300
GIPRLLDPED VDVDKPDEKS VMTYVAQFLN HYPDIHNTGT DGQENDREDR 
       310        320        330        340        350
LILKETKVWI EQFERDLTRA QMTESNLQDK YQSFKHFRVQ YEIKRKQIEH 
       360        370        380        390        400
LIQPVHRNGK LSLDQALVKQ SWDRVSSRLF DWHIQLDKSL PAPLGTIGAW 
       410        420        430        440        450
LYRAEVALRE EITIQQVHEE TANTIQRKRE QHKDLLQNTD AHKRAFHEIY 
       460        470        480        490        500
RTRSVNGIPV PPDQLEDMAE RFHFVSSTSE LHLMKMEFLE LKYRLLSLLV 
       510        520        530        540        550
LAESKLKSWI IKYGRRESVE MLLQNYISFI ENTKFFEQYE VTYQILKQTA 
       560        570        580        590        600
EMYIQADGSV EEAENVMKFM NETTAQWRNL SVEVRSVRSM LEEVIANWDR 
       610        620        630        640        650
YGNTVASLQA WLEDAEKMLN QSEHAKKDFF RNLPHWIQQH AAMNDAGNFL 
       660        670        680        690        700
IETCDEMVSR DLKQQLLLLN GRWRELFMEV KQYARADEMD RMKKEYTDCV 
       710        720        730        740        750
TVLSDFANEA HKKLSEPLEV SFLNVKLLIQ DLEDIEQRVP VMDAQYKMIT 
       760        770        780        790        800
KTAHLITKES SQEEANEMFA TMSRLKEQLT KVKECHSPLL YESRQLLIPL 
       810        820        830        840        850
EELEKQMTLF YDSLGKINEI LTVLEHVAQS SALFKQKQQE LSACQESCKK 
       860        870        880        890        900
TMTQIEKGSQ NVQKFVTLSS LLKHFDQTKL HRQIADVHGA FQNMVKKIGD 
       910        920        930        940        950
WKKHVETNSR LMKKFEESRA ELEKVLRIAQ EGLEEKGNPE DLLKRHTEFF 
       960        970        980        990       1000
SQLDQRVLNA FLKACDELTD ILPEQEQQGL QEAVRKLHKQ WKDLQGEAPY 
      1010       1020       1030       1040       1050
HLLHLKIDVE KNRFLASVEE CRTELDRETK LVPQEGSEKI IKEHRIFFSD 
      1060       1070       1080       1090       1100
KGPHHLCEKR LQLIEELCLK LPVRDPVRNT PETCHATLKE LRATIDTTYM 
      1110       1120       1130       1140       1150
KLVEDPDKWK DYTSRISEFS SWISAKETQL RGFKSEPFDT ANHGEIKCAV 
      1160       1170       1180       1190       1200
EEIRNGVTTK GETLNWLKSR LKILIEVSSE NEARKQGDEL AKLSSSFKAL 
      1210       1220       1230       1240       1250
VALLSEVEKM LSNFRDCVQY KEIVKSSLEE LISGSKEVQE QAEKILDTEN 
      1260       1270       1280       1290       1300
LFEAQQLLLH HQQKTKRISA RKRDVQQNIA QAQQGEGGLP GQVREELRKL 
      1310       1320       1330       1340       1350
ESTLDSMEHS REKQERRIQV TLRKWERFET NKETVVRYLF QTGSSHERFL 
      1360       1370       1380       1390       1400
SFSSLESLSS ELEQTKEFSK RTEGIAVQAE NLVKEASEIP LGPKNKQLLQ 
      1410       1420       1430       1440       1450
QQAKSIKEQV KKLEDTLEED IKTMEMVKNK WDHFGNNFET LSIWITEKEK 
      1460       1470       1480       1490       1500
ELNALETSSS AMDMQIHQIK VAIQEIESKI SSITELEEEA QSFAQFVTTG 
      1510       1520       1530       1540       1550
ESARIKAKLT QIRRYWEELR EHAQCLEGKI LGHLSQQQKF EETLRKIQKS 
      1560       1570       1580       1590       1600
VSEFEDKLAD PIKICSSATE TYKVLQEHMD LCQALEVLRS AVATTSASAQ 
      1610       1620       1630       1640       1650
KVANRSSSIQ EASALQVRYK ETQTRAKERQ TVLENLLAHW QRLEKELSTF 
      1660       1670       1680       1690       1700
LTWLERCEAI ASSPEMDISA DRVKVESELQ SIQALQNEVV SQASIYSNLL 
      1710       1720       1730       1740       1750
QLKESLFSVA SKDDVKMMKV HLEHLDERWR DLPQIISKRI TFLQSVVAEH 
      1760       1770       1780       1790       1800
QQFDELLLSF SVWIKLFLSE LQTTSEISIT DHQAAFTRHK DHAAEVESKK 
      1810       1820       1830       1840       1850
EELQSLQDHL VKLGALGQAE SLHLLQGKAE DCFQLLEEAS QVVERRQLAL 
      1860       1870       1880       1890       1900
SQLAEFLQSH ASLSGVLNRL RHTVEATDSM NRKQTDLLEK DLNHAIQDAK 
      1910       1920       1930       1940       1950
TLESAAISLD SLLAKAQYHL KSGSSEQRTS CRTTADHLCS ELERIQNLLG 
      1960       1970       1980       1990       2000
TKQSEADALA VLKKAFQDQK EELLKSIEDI EERTDKERLK ELTRQALQQR 
      2010       2020       2030       2040       2050
LRVFNQLEDE LNSHEHELCW LKDKAKQIAQ KDVAFASEVD REVNRLEVTW 
      2060       2070       2080       2090       2100
DDTKRLIHEN QGQCCGLIDL MREYQNFKLA VSKVLENASN VIATRTTIKD 
      2110       2120       2130       2140       2150
QEDLKWALSK HETVKNEMCN KQKELDNFTS NGKQLLSELK KIHSSDFILV 
      2160       2170       2180       2190       2200
KTDMESTVDR WLDISEKIEE NMDRLRISLT IWADVLSSKD EIDGWSNSSV 
      2210       2220       2230       2240       2250
PQLTESISNL NNSLRAEEFL KEFESEVKNK ALRLEELHCK VNDLKELTKN 
      2260       2270       2280       2290       2300
PETPPDLQFI EADLRQKLEH AKEITEEAKG TLKDFTAQST QVEKFISDIT 
      2310       2320       2330       2340       2350
SWLTKVEESL KNCAQTETWE GLKKVKEMQK ELQSQQSNIS STQENLNSLC 
      2360       2370       2380       2390       2400
RKYHSVELEG LGSALTGLIK NHEAVTQLCS KTQASLQDSL EKHFNESMQE 
      2410       2420       2430       2440       2450
FQEWFSGIKA AAKESSDRTG DSKVLEAKLH DLQNILDSIS DGQSKLDAVT 
      2460       2470       2480       2490       2500
QEGQTLYAHV SKQIVSSIQE QITKANEEFQ AFLKQCLKDK QALQDCALEL 
      2510       2520       2530       2540       2550
GSFEDQHRKL NLWIHEMDER LSTENLGESK QHIPEKKNEV HKVEMFLGEL 
      2560       2570       2580       2590       2600
LAARESLDKL SQRGQLLSEE GHGAGKEGRL CSQLLTNYQN LLRMTKERLR 
      2610       2620       2630       2640       2650
SCQVALQEHE ALEEALQSMW SWVKGIQDRL TAAESTVGSK DTLEKRLLQI 
      2660       2670       2680       2690       2700
QDILLMKGEG EVKLNMAIGK GEQALRSSNK QGQKVIQTQL QTLKDVWADI 
      2710       2720       2730       2740       2750
MSSSVRAQST LESVISEWND YLEWKNQLEQ WMESADQKVE HPLQLQPGLK 
      2760       2770       2780       2790       2800
EKFSLLDHFQ SILSEAEDHA RALQSLTSKS RELYQKTEDE SFKETAQEEL 
      2810       2820       2830       2840       2850
KTQFNDIITV SKEKMRKVEE IVKDHLMYLD AVQEFTDWLH SAKEELHRWS 
      2860       2870       2880       2890       2900
DVSGDSSATQ KKLSKIKELM DSREIGASRR GRVESLAPAV KQHTSASGCE 
      2910       2920       2930       2940       2950
LMDTEMQALR ADWKQWEDSV LQTQTSLENL VSQMALSEQE FSGQVAHLEQ 
      2960       2970       2980       2990       3000
VLDQFSTLLT TWAQQLALLE GKNTDKEIVE CWQKGQEILD ALQKAEPKIE 
      3010       3020       3030 
DLKSQLNELC RFSRDLSTYS GKVSGLIKEY NW
Length:3,032
Mass (Da):349,230
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE82F4B948DA6729
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_021548914.1, XM_021693239.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_021548914.1, XM_021693239.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi29088.A0A2Y9HHN6

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 2 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 10 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9HHN6_NEOSC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9HHN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: January 19, 2022
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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