Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 11 (12 Aug 2020)
Sequence version 1 (12 Sep 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

MDS1 and EVI1 complex locus protein isoform X1

Gene

MECOM

Organism
Physeter macrocephalus (Sperm whale) (Physeter catodon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MDS1 and EVI1 complex locus protein isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MECOMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhyseter macrocephalus (Sperm whale) (Physeter catodon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9755 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaWhippomorphaCetaceaOdontocetiPhyseteridaePhyseter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248484 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 162SETInterPro annotationAdd BLAST113
Domaini181 – 209C2H2-typeInterPro annotationAdd BLAST29
Domaini235 – 262C2H2-typeInterPro annotationAdd BLAST28
Domaini263 – 290C2H2-typeInterPro annotationAdd BLAST28
Domaini291 – 320C2H2-typeInterPro annotationAdd BLAST30
Domaini321 – 348C2H2-typeInterPro annotationAdd BLAST28
Domaini349 – 376C2H2-typeInterPro annotationAdd BLAST28
Domaini378 – 405C2H2-typeInterPro annotationAdd BLAST28
Domaini894 – 921C2H2-typeInterPro annotationAdd BLAST28
Domaini922 – 950C2H2-typeInterPro annotationAdd BLAST29
Domaini951 – 978C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni483 – 503DisorderedSequence analysisAdd BLAST21
Regioni519 – 584DisorderedSequence analysisAdd BLAST66
Regioni697 – 794DisorderedSequence analysisAdd BLAST98
Regioni973 – 992DisorderedSequence analysisAdd BLAST20
Regioni1012 – 1095DisorderedSequence analysisAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 30PolarSequence analysisAdd BLAST22
Compositional biasi484 – 503PolarSequence analysisAdd BLAST20
Compositional biasi532 – 552PolyampholyteSequence analysisAdd BLAST21
Compositional biasi553 – 573PolarSequence analysisAdd BLAST21
Compositional biasi739 – 758PolarSequence analysisAdd BLAST20
Compositional biasi759 – 779PolyampholyteSequence analysisAdd BLAST21
Compositional biasi976 – 991PolarSequence analysisAdd BLAST16
Compositional biasi1012 – 1027PolarSequence analysisAdd BLAST16
Compositional biasi1048 – 1067AcidicSequence analysisAdd BLAST20
Compositional biasi1081 – 1095PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00317, SET, 1 hit
SM00355, ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A2Y9EG72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDADGVAST LSLNIQEPCS PATSSEAFTP KEGSPYKAPI YIPDDIPIPA
60 70 80 90 100
EFELRESNMP GAGLGIWTKR KIEAGEKFGP YVGEQRSNLK DPSYGWEILD
110 120 130 140 150
EFCNVKFCID ASQPDVGSWL KYIRFAGCYD QHNLVACQIN DQIFYRVVAD
160 170 180 190 200
IAPGEELLLF MKSEDYPHDT MAPDIHEERQ YRCEDCDQLF ESKAELADHQ
210 220 230 240 250
KFPCSTPHSA FSMVEEDFQQ KLASENDLRE IHAIQECKEC DQVFPDLQSL
260 270 280 290 300
EKHMLSHTEE REYKCDQCPK AFNWKSNLIR HQMSHDSGKH YECENCAKQV
310 320 330 340 350
FTDPSNLQRH IRSQHVGARA HACPECGKTF ATSSGLKQHK HIHSSVKPFI
360 370 380 390 400
CEVCHKSYTQ FSNLCRHKRM HADCRTQIKC KDCGQMFSTT SSLNKHRRFC
410 420 430 440 450
EGKNHFAAGG FFGQGISLPG TPAMDKTSMV NMSHANPGLA DYFGANRHPA
460 470 480 490 500
GLTFPTAPGF SFSFPGLFPS GLYHRPPLIP ASSPVKGLSS TEQTNKSQSP
510 520 530 540 550
LMTHPQILPA TQDILKALSK HPPVGDNKPV ELQPERSSEE RPLEKISDQS
560 570 580 590 600
ESSDLDDVST PSGSDLETTS GSDLESDIES DKEKCKENGK MFKDKVSPLP
610 620 630 640 650
NLASIHNKKE YSNHSIFSPS LEEQTAVSGA VNDSIKAIAS IAEKYFGSAG
660 670 680 690 700
LVGLQDKKVG ALPYPSMFPL PFFPAFSQSM YPFPDRDLRA LPLKMEPQSP
710 720 730 740 750
SEVKKLQKGS SESPFDLTTK RKDEKPLTPV PAKPPVTPAT SQDQPLDLSM
760 770 780 790 800
GSRSRASGTK LTEPRKNHVF GEKKGGNGEP RPASDGSLQH ARPTPFFMDP
810 820 830 840 850
IYRVEKRKLT DPLEALKEKY LRPSPGFLFH PQFQLPDQRT WMSAIENMAE
860 870 880 890 900
KLESFSALKP EASELLQSVP SMFNFRAPPN ALPENLLRKG KERYTCRYCG
910 920 930 940 950
KIFPRSANLT RHLRTHTGEQ PYRCKYCDRS FSISSNLQRH VRNIHNKEKP
960 970 980 990 1000
FKCHLCDRCF GQQTNLDRHL KKHENGNMSG TATSSPHSEL ESTGAILDDK
1010 1020 1030 1040 1050
EDAYFTEIRN FIGNSNHSGQ SPRTTEERMN GSHFKDEKAL VTSQNSDLLD
1060 1070 1080 1090 1100
DEEVEDEVLL DEEDEDNDIT GKTGKEPGTS NLHEGNHEDD YEDTSALEMS
1110 1120 1130 1140 1150
CKTSPMRYKE EEYKTGLSAL DHIRHFTDSL KMRKMEDNQY IEAEVSSFSA
1160 1170 1180 1190 1200
SHVPEELKQP LHRKSKSQAY AMMLSLSDKE TLHSSSHNSS NVWHSMARAA
1210
AESSAIQSIS HV
Length:1,212
Mass (Da):135,998
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB397FB7F8841069A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9EFH5A0A2Y9EFH5_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
1,203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9EFI0A0A2Y9EFI0_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
1,211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9EH41A0A2Y9EH41_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
1,202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9EHE0A0A2Y9EHE0_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
1,110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9SP23A0A2Y9SP23_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
878Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9SRJ2A0A2Y9SRJ2_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
888Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9EGS8A0A2Y9EGS8_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
1,052Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9EGT1A0A2Y9EGT1_PHYMC
MDS1 and EVI1 complex locus protein...
MECOM
1,000Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007101645.1, XM_007101583.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102976185

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007101645.1, XM_007101583.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi102976185

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2122

Family and domain databases

InterProiView protein in InterPro
IPR001214, SET_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00317, SET, 1 hit
SM00355, ZnF_C2H2, 10 hits
SUPFAMiSSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9EG72_PHYMC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9EG72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: August 12, 2020
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again