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UniProtKB - A0A2Y9DBC1 (A0A2Y9DBC1_TRIMA)

Entry version 12 (10 Feb 2021)
Sequence version 1 (12 Sep 2018)
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Protein
Submitted name:

son of sevenless homolog 2 isoform X1

Gene

LOC101347392

Organism
Trichechus manatus latirostris (Florida manatee)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
son of sevenless homolog 2 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC101347392Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrichechus manatus latirostris (Florida manatee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri127582 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Afrotheria › Sirenia › Trichechidae › Trichechus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248480 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini197 – 387DHInterPro annotationAdd BLAST191
Domaini440 – 543PHInterPro annotationAdd BLAST104
Domaini594 – 738N-terminal Ras-GEFInterPro annotationAdd BLAST145
Domaini777 – 1016Ras-GEFInterPro annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1017 – 1058DisorderedSequence analysisAdd BLAST42
Regioni1140 – 1308DisorderedSequence analysisAdd BLAST169

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili887 – 907Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1150 – 1164PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1172 – 1188Pro-richSequence analysisAdd BLAST17
Compositional biasi1196 – 1224Pro-richSequence analysisAdd BLAST29
Compositional biasi1280 – 1297Pro-richSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...CDDi		cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit
1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR23113, PTHR23113, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00125, Histone, 1 hit
PF00169, PH, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113, SSF47113, 1 hit
SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2Y9DBC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQAQPYEFF SEENSPKWRG LLVSALRKVQ EQVHPNLSAN EESLYYIEDL 
        60         70         80         90        100
IFQLLNKLCM AQPRTVQDVE ERVQKTFPHP IDKWAIADAQ SAIEKRKRRN 
       110        120        130        140        150
PLLLPVDKIH PSLKEVLGYK VDYHVSLYIV AVLEYISADI LKLAGNYVFN 
       160        170        180        190        200
IRHYEISQQD IKVSMCADKV LMDMFDQDDI GLVSLCEDEP SSSGELNYYD 
       210        220        230        240        250
LVRTEIAEER QYLRELNMII KVFREAFLSD RKLFKPSDIE KIFSNISDIH 
       260        270        280        290        300
ELTVKLLGLI EDTVEMTDES SPHPLAGSCF EDLAEEQAFD PYETLSQDIL 
       310        320        330        340        350
SPKFNEHFSK LMARPAVALH FQSISDGFKE AVRYVLPRLM LVPVYHCWHY 
       360        370        380        390        400
FELLKQLKAC SEEQEDEECL NQAITALMNL QGSMDRIYKQ YSPRRRPGDP 
       410        420        430        440        450
VSPFYNRQLR SKHLAIKKMN EIQKNIDGWE GKDIGQCCNE FIMEGPLTRI 
       460        470        480        490        500
GAKHERHIFL FDGLMISCKP NHGQSRLPGY NNAEYRLKEK FVMRKTQVCD 
       510        520        530        540        550
KEDTCECKHA FELISKDENS IVFAAKSAEE KNNWMAALIS LQYRSTLDRM 
       560        570        580        590        600
LDSVLLKEEN EQPLRLPSPE VYRFVVKDSE ENIVFEDNLQ SRSGIPIIKG 
       610        620        630        640        650
GTVVKLIERL TYHMYADPNF VRTFLTTYRS FCKPQELLSL LIERFEIPEP 
       660        670        680        690        700
EPTEADKLAI EKGEQPISAD LKRFRKEYVQ PVQLRILNVF RHWVEHHFYD 
       710        720        730        740        750
FERDLELLER LESFISSVRG KAMKKWVESI AKIMKRKKQA QANGISHNIT 
       760        770        780        790        800
FESPPPPIEW HISRSGQSET FDLMTLHPIE IARQLTLLES DLYRKVQPSE 
       810        820        830        840        850
LVGSVWTKED KEINSPNLLK MIRHTTNLTL WFEKCIVEAE NFEERVAVLS 
       860        870        880        890        900
RIIEILQVFQ DLNNFNGVLE IVSAVNSVSV YRLDHTFEAL QERKRRILDE 
       910        920        930        940        950
AVELSQDHFK KYLAKLKSIN PPCVPFFGIY LTNILKTEEG NNDFLKKKGK 
       960        970        980        990       1000
DLINFSKRRK VAEITGEIQQ YQNQPYCLRI EPDMRRFFEN LNPMGSASEK 
      1010       1020       1030       1040       1050
EFTDYLFNKS LEIEPRNCKQ PPRFPRKSTF SLKSPGIRPN AGRHGSTSGT 
      1060       1070       1080       1090       1100
LRGHPTPLER EPCKISFSRI AETELESTMS APTSPNTPCT PPVSASSELS 
      1110       1120       1130       1140       1150
VFLDVDLNSS CGSNSIFAPV LLPHSKSFFS SCGSLHKLSE EPLVPPPLPP 
      1160       1170       1180       1190       1200
RKKFDHDASN SKGNMKSDDD PPAIPPRQPP PPKVKPRVPV PIGAFDGPLH 
      1210       1220       1230       1240       1250
SPPPPPPRDP LPDTPPPVPL RPPEHFINCP FNLQPPPMGH LHRDVRDAST 
      1260       1270       1280       1290       1300
CPNSPNTPPS TPSPRVPRRC YVLSSSQNNL PHPPAPPVPP RQNSSPHLPK 
      1310       1320 
LPPKTYKREL LHPSLYRLPL LENAETPQ
Length:1,328
Mass (Da):152,469
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA70AF7D0A2DF6A2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9QF27A0A2Y9QF27_TRIMA
son of sevenless homolog 2 isoform ...
LOC101347392
1,216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9QRD1A0A2Y9QRD1_TRIMA
son of sevenless homolog 2 isoform ...
LOC101347392
1,260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9QRQ7A0A2Y9QRQ7_TRIMA
son of sevenless homolog 2 isoform ...
LOC101347392
1,269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2Y9QKD9A0A2Y9QKD9_TRIMA
son of sevenless homolog 2 isoform ...
LOC101347392
1,164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_004370899.1, XM_004370842.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		101347392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		tmu:101347392

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_004370899.1, XM_004370842.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi101347392
KEGGitmu:101347392

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.10.20.10, 1 hit
1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
PANTHERiPTHR23113, PTHR23113, 1 hit
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PF00169, PH, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2Y9DBC1_TRIMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2Y9DBC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: February 10, 2021
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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