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Entry version 17 (12 Aug 2020)
Sequence version 1 (12 Sep 2018)
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Protein

8-amino-7-oxononanoate synthase

Gene

bioF

Organism
Salmonella enterica I
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateUniRule annotationARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotationARBA annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei21SubstrateUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei179Pyridoxal phosphateUniRule annotation1
Binding sitei207Pyridoxal phosphateUniRule annotation1
Binding sitei233Pyridoxal phosphateUniRule annotation1
Binding sitei352SubstrateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferaseImported, Transferase
Biological processBiotin biosynthesisUniRule annotationARBA annotation
LigandPyridoxal phosphateUniRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00078

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
8-amino-7-oxononanoate synthaseUniRule annotation (EC:2.3.1.47UniRule annotation)
Short name:
AONSUniRule annotation
Alternative name(s):
7-keto-8-amino-pelargonic acid synthaseUniRule annotation
Short name:
7-KAP synthaseUniRule annotation
Short name:
KAPA synthaseUniRule annotation
8-amino-7-ketopelargonate synthaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bioFUniRule annotationImported
ORF Names:ADT85_09945Imported, AVH38_22525Imported, CF93_14000Imported, D4444_18175Imported, D5C34_17685Imported, D5P75_20255Imported, D5P94_22435Imported, D6P63_18060Imported, DK101_18215Imported, DKI94_13335Imported, DLB02_12415Imported, DLB73_11735Imported, DN087_16155Imported, DN241_19705Imported, DNM22_21110Imported, DO619_20585Imported, DO696_16760Imported, DO973_21280Imported, DPF65_19795Imported, DPS62_18325Imported, DPU11_12415Imported, DQC75_20710Imported, DQJ23_16120Imported, DQJ50_18035Imported, DRT56_19560Imported, DUQ64_12220Imported, DUR88_08625Imported, EBD25_20880Imported, EBK37_16390Imported, EC453_18125Imported, EGL44_16400Imported, F3554_19505Imported, QD82_15165Imported, QF21_21040Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella enterica IImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59201 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236N6-(pyridoxal phosphate)lysineUniRule annotation1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 379Aminotran_1_2InterPro annotationAdd BLAST340

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni108 – 109Pyridoxal phosphate bindingUniRule annotation2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.UniRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01693, BioF_aminotrans_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001917, Aminotrans_II_pyridoxalP_BS
IPR004839, Aminotransferase_I/II
IPR004723, AONS_Archaea/Proteobacteria
IPR022834, AONS_Proteobacteria
IPR015424, PyrdxlP-dep_Trfase
IPR015422, PyrdxlP-dep_Trfase_dom1
IPR015421, PyrdxlP-dep_Trfase_major

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00155, Aminotran_1_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53383, SSF53383, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00858, bioF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00599, AA_TRANSFER_CLASS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2X5BH95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWQQRVDDA LTARRATDTL RRRYVVSQGA GRWLVANGRQ YLNFSSNDYL
60 70 80 90 100
GLSQHPQIIR AWQQAATRFG VGSGGSGHIS GYSVAHQALE VELAQWLEYP
110 120 130 140 150
RALLFISGFA ANQAVITALM KKNDRIVADR LSHASLLEAA NLSPAQLRRF
160 170 180 190 200
IHNDTQHLSR LLQSPCVGQQ LVVTEGVYSM DGDSAPLAEI QHIARRHHAW
210 220 230 240 250
LLVDDAHGIG VTGDEGRGTC WQRGVKPELL VVTFGKGFGV SGAAVLCSES
260 270 280 290 300
VADYLLQFAR HLVYSTSMPP AQAQALSASL AVIRSDEGRE RREKLAALVQ
310 320 330 340 350
RFRAGVNASR FTLLNAHSAI QPLIVGDNSR ALRLAEALRQ QGCWATAIRP
360 370 380
PTVPVGTARL RLTLTQAHEA CDIDRLLEVL HGAGE
Length:385
Mass (Da):42,084
Last modified:September 12, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i328DDD7757F55A81
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAAHJ010000007 Genomic DNA Translation: EAA0473776.1
AAAAKN010000012 Genomic DNA Translation: EAA0897529.1
AAAAME010000010 Genomic DNA Translation: EAA1066420.1
AAAAMQ010000027 Genomic DNA Translation: EAA1142020.1
AAAAXK010000027 Genomic DNA Translation: EAA2540711.1
AAABDG010000025 Genomic DNA Translation: EAA3225660.1
AAABDX010000020 Genomic DNA Translation: EAA3414021.1
AAABKB010000014 Genomic DNA Translation: EAA4017269.1
AAABJS010000023 Genomic DNA Translation: EAA4117545.1
AAABKQ010000026 Genomic DNA Translation: EAA4229577.1
AAABNG010000025 Genomic DNA Translation: EAA4500129.1
AAABRA010000037 Genomic DNA Translation: EAA4942713.1
AAABSL010000006 Genomic DNA Translation: EAA5141367.1
AAABVI010000026 Genomic DNA Translation: EAA5421414.1
AAABWH010000037 Genomic DNA Translation: EAA5549539.1
AAABWN010000014 Genomic DNA Translation: EAA5685276.1
AAACFP010000034 Genomic DNA Translation: EAA6694326.1
AAACKZ010000028 Genomic DNA Translation: EAA7353496.1
AAACKK010000007 Genomic DNA Translation: EAA7366313.1
AAACZL010000004 Genomic DNA Translation: EAA9160404.1
AAAFEP010000020 Genomic DNA Translation: EAB5928289.1
AAAFPC010000028 Genomic DNA Translation: EAB7119725.1
AAAFTE010000019 Genomic DNA Translation: EAB7701768.1
AAAFUU010000011 Genomic DNA Translation: EAB7891002.1
AAAFZX010000012 Genomic DNA Translation: EAB8497338.1
AAAGDG010000011 Genomic DNA Translation: EAB8968352.1
AAAGDL010000011 Genomic DNA Translation: EAB9071544.1
AAAGJT010000027 Genomic DNA Translation: EAB9683497.1
AAAGLV010000012 Genomic DNA Translation: EAB9951680.1
AAAGOM010000009 Genomic DNA Translation: EAC0309608.1
AAAGOY010000008 Genomic DNA Translation: EAC0389642.1
AAAGUZ010000050 Genomic DNA Translation: EAC1087126.1
AAGLNY010000007 Genomic DNA Translation: EBP3759242.1
AAKXPR010000026 Genomic DNA Translation: ECW7923876.1

NCBI Reference Sequences

More...
RefSeqi
WP_000118945.1, NZ_QJFY01000023.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAAHJ010000007 Genomic DNA Translation: EAA0473776.1
AAAAKN010000012 Genomic DNA Translation: EAA0897529.1
AAAAME010000010 Genomic DNA Translation: EAA1066420.1
AAAAMQ010000027 Genomic DNA Translation: EAA1142020.1
AAAAXK010000027 Genomic DNA Translation: EAA2540711.1
AAABDG010000025 Genomic DNA Translation: EAA3225660.1
AAABDX010000020 Genomic DNA Translation: EAA3414021.1
AAABKB010000014 Genomic DNA Translation: EAA4017269.1
AAABJS010000023 Genomic DNA Translation: EAA4117545.1
AAABKQ010000026 Genomic DNA Translation: EAA4229577.1
AAABNG010000025 Genomic DNA Translation: EAA4500129.1
AAABRA010000037 Genomic DNA Translation: EAA4942713.1
AAABSL010000006 Genomic DNA Translation: EAA5141367.1
AAABVI010000026 Genomic DNA Translation: EAA5421414.1
AAABWH010000037 Genomic DNA Translation: EAA5549539.1
AAABWN010000014 Genomic DNA Translation: EAA5685276.1
AAACFP010000034 Genomic DNA Translation: EAA6694326.1
AAACKZ010000028 Genomic DNA Translation: EAA7353496.1
AAACKK010000007 Genomic DNA Translation: EAA7366313.1
AAACZL010000004 Genomic DNA Translation: EAA9160404.1
AAAFEP010000020 Genomic DNA Translation: EAB5928289.1
AAAFPC010000028 Genomic DNA Translation: EAB7119725.1
AAAFTE010000019 Genomic DNA Translation: EAB7701768.1
AAAFUU010000011 Genomic DNA Translation: EAB7891002.1
AAAFZX010000012 Genomic DNA Translation: EAB8497338.1
AAAGDG010000011 Genomic DNA Translation: EAB8968352.1
AAAGDL010000011 Genomic DNA Translation: EAB9071544.1
AAAGJT010000027 Genomic DNA Translation: EAB9683497.1
AAAGLV010000012 Genomic DNA Translation: EAB9951680.1
AAAGOM010000009 Genomic DNA Translation: EAC0309608.1
AAAGOY010000008 Genomic DNA Translation: EAC0389642.1
AAAGUZ010000050 Genomic DNA Translation: EAC1087126.1
AAGLNY010000007 Genomic DNA Translation: EBP3759242.1
AAKXPR010000026 Genomic DNA Translation: ECW7923876.1
RefSeqiWP_000118945.1, NZ_QJFY01000023.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Enzyme and pathway databases

UniPathwayiUPA00078

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_01693, BioF_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917, Aminotrans_II_pyridoxalP_BS
IPR004839, Aminotransferase_I/II
IPR004723, AONS_Archaea/Proteobacteria
IPR022834, AONS_Proteobacteria
IPR015424, PyrdxlP-dep_Trfase
IPR015422, PyrdxlP-dep_Trfase_dom1
IPR015421, PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155, Aminotran_1_2, 1 hit
SUPFAMiSSF53383, SSF53383, 1 hit
TIGRFAMsiTIGR00858, bioF, 1 hit
PROSITEiView protein in PROSITE
PS00599, AA_TRANSFER_CLASS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2X5BH95_SALET
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2X5BH95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 12, 2018
Last sequence update: September 12, 2018
Last modified: August 12, 2020
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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