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Entry version 5 (05 Dec 2018)
Sequence version 1 (18 Jul 2018)
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Protein
Submitted name:

protocadherin-16

Gene

DCHS1

Organism
Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
protocadherin-16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCHS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9739 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiDelphinidaeTursiops
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000245320 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1784 – 1810HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 58CAInterPro annotationAdd BLAST58
Domaini88 – 168CAInterPro annotationAdd BLAST81
Domaini200 – 283CAInterPro annotationAdd BLAST84
Domaini307 – 393CAInterPro annotationAdd BLAST87
Domaini416 – 496CAInterPro annotationAdd BLAST81
Domaini520 – 598CAInterPro annotationAdd BLAST79
Domaini621 – 702CAInterPro annotationAdd BLAST82
Domaini726 – 807CAInterPro annotationAdd BLAST82
Domaini835 – 915CAInterPro annotationAdd BLAST81
Domaini937 – 1018CAInterPro annotationAdd BLAST82
Domaini1042 – 1124CAInterPro annotationAdd BLAST83
Domaini1147 – 1223CAInterPro annotationAdd BLAST77
Domaini1247 – 1329CAInterPro annotationAdd BLAST83
Domaini1353 – 1449CAInterPro annotationAdd BLAST97
Domaini1473 – 1553CAInterPro annotationAdd BLAST81
Domaini1577 – 1660CAInterPro annotationAdd BLAST84
Domaini1684 – 1775CAInterPro annotationAdd BLAST92

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 14 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 17 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2U4CEV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISVCPALPG EVTTLQTLDR ERQSSYQLLV QVQDGGSPPR SVTGTIHIAV
60 70 80 90 100
LDLNDNSPTF LQASGAAGGG LPIQVPDGVP PGTLVTTLQA RDPDEGENGT
110 120 130 140 150
ILYMLTGPGS ELFSLHPHSG ELLTAAPLTR AERPHYVLTL SAHDQGSPPR
160 170 180 190 200
SSSLQLLVQV LPSARSAEPP PEPSDPDPAA PVPVVLTVTA AEGLQPGSLL
210 220 230 240 250
GSVAPPESAG VGALTYTLVG GADPEGTFAL DAASGRLYLA RPLDFEAGPA
260 270 280 290 300
WRALTVRAEG PGGAGARLLR VQVRVQDENE HAPAFARDPL AVALPENPEP
310 320 330 340 350
GAALYTFRAS DADGPGPNSD VRYRLLRQEP PVPALRLDSR TGALSAPRGL
360 370 380 390 400
DRETTPALLL LVEATDRPAN ASRRRAARVS ARVFVTDEND NAPVFASPSR
410 420 430 440 450
VRLSEDQPPG PAALHVVARD PDLGEAARVS YRLAAGGDGY FRLHPSTGAL
460 470 480 490 500
SVVRSLDREQ RAEFLLTVVA SDHGSPPRSA TQLLTVSVAD VNDEAPTFQQ
510 520 530 540 550
QEYSVLLREN SPPGTSLLTL RATDPDLGAN GQVTYGGISG ESFSLDPDTG
560 570 580 590 600
VLTTLRALDR EEQEEINLTV YARDGGSPPL LTHVTVRVAV EDENDHAPTF
610 620 630 640 650
GSAHLSLEVP EGQDPQTLTT LRASDPDVGA NGQLQYRILD GDPSEAFVLD
660 670 680 690 700
LASGEFGTMR PLDREVEPAF QLQIEARDGG QPALSATLFV TVTVLDANDH
710 720 730 740 750
APAFPVPAYS VEVPEDAPAG TLLLQLQAHD PDAGPNGRVT YYLGAGAAGA
760 770 780 790 800
FLLEPSSGEL RTATALDREQ CPSYAFTVNA VDGAAAGPLS TTVPITIMVR
810 820 830 840 850
DVNDHAPTFP TSPLRLRLPR PGPSLSTPTL ALATLRAEDR DAGANASILY
860 870 880 890 900
RLAGTPPPGT TVDSYTGEIR VARSPVSLGP QDRVLFIVAT DLGRPARSAT
910 920 930 940 950
GVVIVGLQGE SERGPRFPRA SSEAMLRENA PPGTPIVSPK AIHTGGSSGP
960 970 980 990 1000
ITYSILSGNE KGTFSIQPST GAVTVRSAEG LDFEANPRLR LVLQAESGGA
1010 1020 1030 1040 1050
FAFSVLTLTL QDANDNAPRF LRPHYVAFLP ESRPLEGPLL QVEADDLDQG
1060 1070 1080 1090 1100
PSGQISYSLA ASQPARGLFR VDSATGTITT TAILDREIWA ETRLVLMATD
1110 1120 1130 1140 1150
RGSPALVGSA TLTVMVIDTN DNRPTIPQPW ELRVSEDALL GSEIAQVTGN
1160 1170 1180 1190 1200
DVDSGPVLWY VLSPSGPQDP FSVGRYGGRL SLTGPLDFEQ RDRYHLQLLA
1210 1220 1230 1240 1250
HDGPHEGRAN LTVLVEDVND NAPAFSQTLY QVMLLEHTPP GSAILSVSAT
1260 1270 1280 1290 1300
DRDSGANGHV SYHLASPAEG FSVDPNNGTL FTTVGTMALG HEGPGVVDVV
1310 1320 1330 1340 1350
LEARDHGTPA RAARTTVHVQ LQDQNDHTPS FTLSHYRVAV TEDLPPGSTL
1360 1370 1380 1390 1400
LTLEATDADG SRTHATVDYS IVSGNRGRVF QLEPRLAETG ESDGLGPRAL
1410 1420 1430 1440 1450
GCLVLLEPLD FESLTQYNLT VAAADRGQPP RSSAVPVTVT VLDVNDNPPV
1460 1470 1480 1490 1500
FTRASYRVAV PEDTPVGAEL LHVEASDADP GPHGLVRFTL SSGDPFGLFQ
1510 1520 1530 1540 1550
LDESSGDLRL AHPLDCETQA RHQLVVRAAD PAGAHFALAP VTIEVQDVND
1560 1570 1580 1590 1600
HRPAFPLGLL STSLAENQPP GTLVTTLHAT DGDAGAFGRL RYDLLDAGPG
1610 1620 1630 1640 1650
PEGREAFALN SSTGELRARV AFDYEHTGSF QLLVGATDAG NLSASVTVSV
1660 1670 1680 1690 1700
LVTGEDEYDP VFLAPAFHFQ VPEGARRGHS LGHVQATDED GGADGLVLYS
1710 1720 1730 1740 1750
LATSSPYFGI NQTTGALYLR VDSRAPGSGT GTSGGGGRTR REAPRELRLE
1760 1770 1780 1790 1800
VVARGPLPGS RSATVPVTVD ITHTALGLAP DLNLLLVGAV AASLGVVVVL
1810 1820 1830 1840 1850
ALAALVLGLV RARSRKAEAA PGPMSQAAPL ASGSLQKLGR EPPSPPPSEH
1860 1870 1880 1890 1900
LYHQTLPSYG GPGAGGPYPR GGSLDPSHSS GRGSAEAAED DEIRMINEFP
1910 1920 1930 1940 1950
RVASVASSLA ARGPDSGIQQ DADGLSDTSC EPPAPDTWYK GRKAGLLLPG
1960 1970 1980 1990 2000
AGATLYREEG PPAAATAFLG GCGLSPAPTG DYGFPADGKP CVAGALTAIV
2010 2020 2030 2040 2050
AGEEELRGSY NWDYLLSWCP QFQPLASVFT EIARLKDEAR PCPPAPRIDP
2060 2070 2080 2090 2100
PPLITAVAHP GAKSVPPKPA STATTRAIFP PASHRSPISH EGSLSSAAMS
2110 2120 2130 2140
PSFSPSLSPL AARSPVVSPF GVAQGPSASA LSAESGLEPP DDTELHI
Length:2,147
Mass (Da):224,504
Last modified:July 18, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0968CE264A8E8DB6
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_019803964.1, XM_019948405.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101325996

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019803964.1, XM_019948405.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101325996

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8642

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PfamiView protein in Pfam
PF00028 Cadherin, 14 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 17 hits
SUPFAMiSSF49313 SSF49313, 17 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2U4CEV7_TURTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2U4CEV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: December 5, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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