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Entry version 7 (05 Jun 2019)
Sequence version 1 (18 Jul 2018)
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Protein
Submitted name:

ubiquitin carboxyl-terminal hydrolase 24 isoform X1

Gene

USP24

Organism
Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ubiquitin carboxyl-terminal hydrolase 24 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP24Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9739 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiDelphinidaeTursiops
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000245320 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 44UBAInterPro annotationAdd BLAST42
Domaini1689 – 2043USPInterPro annotationAdd BLAST355

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 102DisorderedSequence analysisAdd BLAST58
Regioni1034 – 1054DisorderedSequence analysisAdd BLAST21
Regioni1922 – 1946DisorderedSequence analysisAdd BLAST25
Regioni2064 – 2091DisorderedSequence analysisAdd BLAST28
Regioni2575 – 2621DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2575 – 2608PolarSequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR033382 USP24
IPR018200 USP_CS
IPR028889 USP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR24006:SF729 PTHR24006:SF729, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF54001 SSF54001, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030 UBA, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2U4BXP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY
60 70 80 90 100
GGYEPMDSGG GPSPGPGGVS RGDGGGDGGG GGPSRGSSTG GGGGFDPPPA
110 120 130 140 150
YHEVVDAEKN DENGNCSGEG IEFPTTNLYE LESRVLTDHW SIPYKREESL
160 170 180 190 200
GKCLLASTYL ARLGLSESDE NCKRFMDRCM PEAFKKLLTS SAVHKWGTEI
210 220 230 240 250
HEGIYNMLML LIELAAERIK QDPIPTGLLA VLTMAFNPDN EYHFKNRMKV
260 270 280 290 300
SQRNWAEVFG EGNMFAISPV STFQKEPHGW VVDLVNKFGE LGGFAAIQAK
310 320 330 340 350
LHSEDIELGA VSALVQPLGV CAEYLNSSVV QPMLDPVILT TIQDVRSVEE
360 370 380 390 400
KDLKDKRLVS IPELLSAIKL LCMRFQPDLV TVVDDLRLDI LLRMLKSPHF
410 420 430 440 450
SAKMNSLKEV TKLIEDSTLS KSVKNAIDTD RLLDWLVENS VLSIALEGNI
460 470 480 490 500
DQAQYCDRIK GIIELLGSKL SLDELTKIWK IQSGQSSTVI ENIHTIIAAA
510 520 530 540 550
AVKFNSDQLN HLFVLIQKSW ETETDRVRQK LLSLIGRIGR EARFETTSGK
560 570 580 590 600
VLDVLWELAH LPTLPSSLIQ QALEEHLTIL SDAYAVKEAI KRSYIIKCIE
610 620 630 640 650
DIKRPGEWSG LEKNKKDGFK SSQLNNPQFV WVVPALRQLH EITRSFIKQT
660 670 680 690 700
YQKQDKSIIQ DLKKNFEIVK LVTGSLIACH RLAAAVAGPG GLTGSTLVDG
710 720 730 740 750
RYTYREYLEA HLKFLAFFLQ EATLYLGWNR AKEIWECLVT GQDVCELDRE
760 770 780 790 800
MCFEWFTKGQ HDLESDVQQQ LFKEKILKLE SYEITMNGFN LFKTFFENVN
810 820 830 840 850
LCDHRLKRQG AQLYVEKLEL IGMDFIWKIA MESPDEEIAN EAIQLIINYS
860 870 880 890 900
YINLNPRLKK DSVSLHKKFI ADCYTRLEAA SSALGGPTLT HAVTRATKML
910 920 930 940 950
TATAMPTVAT SVQSPYRSTK LVIIERLLLL AERYVITIED FYSVPRTILP
960 970 980 990 1000
HGASFHGHLL TLNVTYESTK DTFTVEAHSN ETIGSVRWKI AKQLCSPVDS
1010 1020 1030 1040 1050
IQIFTNDSLL TVNKDQKLLH QLGFSDEQIL TVKTSGSGTP SGSSADSSTS
1060 1070 1080 1090 1100
SSSSSSGVFS SSYAMEQEKS LPGVVMALVC NVFDMLYQLA NLEEPRITLR
1110 1120 1130 1140 1150
VRKLLLLIPT DPAIQEALDQ LDSLGRKKTL LSETSAQSSK SPSLSSKQQH
1160 1170 1180 1190 1200
QPSASSILES LFRSFAPGMS TFRVLYNLEV LSSKLMPTAD DDMARNCAKS
1210 1220 1230 1240 1250
FCENFLKAGG LSLVVNVMQR DSIPSEVDYE TRQGVYSICL QLARFLLVGQ
1260 1270 1280 1290 1300
TLPTLLEEDL TKDGIEALTS RPFRNVSRQT SRQMSLCGTP EKSSYRQLSV
1310 1320 1330 1340 1350
SDRSSIRVEE IIPAARVAIQ TMEVSDFTST VACFMRLSWA AAAGRLDLVG
1360 1370 1380 1390 1400
SSQPIKESNS LFPAGIRNRL SSSGSNCSSG SEGDPVALHA GICVRQQSVS
1410 1420 1430 1440 1450
TKDSLIAGEA LSLLVTCLQL RSQQLASFYN LPCVADFIID ILLGSPSAEI
1460 1470 1480 1490 1500
RRVACDQLYT LSQTDTSAHP DVQKPNQFLL GVILTAQLPL WSPTSIMRGV
1510 1520 1530 1540 1550
NQRLLSQCME YFDLRCQLLD DLTTSEMEQL RISPATMLED EITWLDNFEP
1560 1570 1580 1590 1600
NRTAECETSE ADNILLAGHL RLIKTLLSLC GAEKEMLGSS LIKPLLDDFL
1610 1620 1630 1640 1650
FRASRIILNS HSPAGSAAIS QQDFHPKCST VNSRLAAYEV LVMLADSSPS
1660 1670 1680 1690 1700
NLQIITKELL SMHHQPDPAL TKEFDYLPPV DSRSSSGFVG LRNGGATCYM
1710 1720 1730 1740 1750
NAVFQQLYMQ PGLPESLLSV DDDTDNPDDS VFYQVQSLFG HLMESKLQYY
1760 1770 1780 1790 1800
VPENFWKIFK MWNKELYVRE QQDAYEFFTS LIDQMDEYLK KMGRDQIFKN
1810 1820 1830 1840 1850
TFQGIYSDQK ICKDCPHSRY EREEAFMALN LGVTSCQSLE ISLDQFVRGE
1860 1870 1880 1890 1900
VLEGSNAYYC EKCKEKRTTV KRTCIKSLPS VLVIHLMRFG FDWESGRSIK
1910 1920 1930 1940 1950
YDEQIRFPWM LNMEPYTVSG MARQDSSSEV GENGRNMDQG GGGSPRKKVA
1960 1970 1980 1990 2000
LTENYELVGV IVHSGQAHAG HYYSFIKDRR GCGKGKWYKF NDTVIEEFDL
2010 2020 2030 2040 2050
NDETLEYECF GGEYRPKVYD QTNPYTDVRR RYWNAYMLFY QRVSDQNSPV
2060 2070 2080 2090 2100
LPKKSRVSVV RQEAEDLSLS APSSPEISPQ SSPRPHRPNN DRLSILTKLV
2110 2120 2130 2140 2150
KKGEKKGLFV EKMPVRIYQM VRDENLKFMK NRDVYSSDYF SFVLSLASLN
2160 2170 2180 2190 2200
ATKLKHPYYP CMAKVSLQLA IQFLFQTYLR TKKKLRVDTE EWIATIEALL
2210 2220 2230 2240 2250
SKSFDACQWL VEYFISSEGR ELIKIFLLEC NVREVRVAVA TILEKTLDSA
2260 2270 2280 2290 2300
LLYQDKLKSL HQLLEVLLAL LDKDVPENCK NCAQYFFLFN TFVQKQGIRA
2310 2320 2330 2340 2350
GDLLLKHSAL RHMISFLLGA NRQNSQIRRW SSAQAREFGN LHNTVALLIL
2360 2370 2380 2390 2400
HSDVSSQRNV APGAFKQRPP ISIAPSSPLL PLHEEVEALL FLSEGKPYLL
2410 2420 2430 2440 2450
EVMFALRELT GSLLALIEMV VYCCFCNEHF SFTMLHFIKN QLETAPPHEL
2460 2470 2480 2490 2500
KNTFQLLHEM LVIEDPIQVE RVKFVFETEN GLLALMHHSN HVDSSRCYQC
2510 2520 2530 2540 2550
VKFLVTLAQK CPAAKEYFKE NSHHWSWAVQ WLQKKMSEHY WTPQSNVSNE
2560 2570 2580 2590 2600
TSTGKTFQRT ISAQDTLAYA TALLNEKEQS GSSNGSESSP ANENGERHLQ
2610 2620
QGSESPMMIS ELRSDLDDVD P
Length:2,621
Mass (Da):294,584
Last modified:July 18, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48683AAE8C6A384E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2U4BXU2A0A2U4BXU2_TURTR
ubiquitin carboxyl-terminal hydrola...
USP24
2,569Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U4BXP7A0A2U4BXP7_TURTR
ubiquitin carboxyl-terminal hydrola...
USP24
2,600Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U4BXN2A0A2U4BXN2_TURTR
ubiquitin carboxyl-terminal hydrola...
USP24
2,620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U4BXT6A0A2U4BXT6_TURTR
ubiquitin carboxyl-terminal hydrola...
USP24
2,620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_019797965.1, XM_019942406.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101315580

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019797965.1, XM_019942406.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101315580

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23358

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR033382 USP24
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR24006:SF729 PTHR24006:SF729, 3 hits
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54001 SSF54001, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2U4BXP1_TURTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2U4BXP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: June 5, 2019
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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