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Protein
Submitted name:

cubilin

Gene

CUBN

Organism
Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cubilinImported
Gene namesi
Name:CUBNImported
OrganismiTursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus)Imported
Taxonomic identifieri9739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiDelphinidaeTursiops
Proteomesi
  • UP000245320 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501562626321 – 3620Sequence analysisAdd BLAST3600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi155 ↔ 164PROSITE-ProRule annotation
Disulfide bondi198 ↔ 207PROSITE-ProRule annotation
Disulfide bondi313 ↔ 330PROSITE-ProRule annotation
Disulfide bondi396 ↔ 406PROSITE-ProRule annotation
Disulfide bondi417 ↔ 426PROSITE-ProRule annotation
Disulfide bondi455 ↔ 464PROSITE-ProRule annotation
Disulfide bondi1617 ↔ 1644PROSITE-ProRule annotation
Disulfide bondi2333 ↔ 2360PROSITE-ProRule annotation
Disulfide bondi3034 ↔ 3061PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 165EGF-likeInterPro annotationAdd BLAST37
Domaini167 – 208EGF-likeInterPro annotationAdd BLAST42
Domaini260 – 301EGF-likeInterPro annotationAdd BLAST42
Domaini302 – 345EGF-likeInterPro annotationAdd BLAST44
Domaini346 – 382EGF-likeInterPro annotationAdd BLAST37
Domaini392 – 427EGF-likeInterPro annotationAdd BLAST36
Domaini429 – 465EGF-likeInterPro annotationAdd BLAST37
Domaini471 – 583CUBInterPro annotationAdd BLAST113
Domaini587 – 699CUBInterPro annotationAdd BLAST113
Domaini705 – 812CUBInterPro annotationAdd BLAST108
Domaini813 – 924CUBInterPro annotationAdd BLAST112
Domaini928 – 1038CUBInterPro annotationAdd BLAST111
Domaini1044 – 1158CUBInterPro annotationAdd BLAST115
Domaini1162 – 1274CUBInterPro annotationAdd BLAST113
Domaini1275 – 1386CUBInterPro annotationAdd BLAST112
Domaini1388 – 1503CUBInterPro annotationAdd BLAST116
Domaini1507 – 1616CUBInterPro annotationAdd BLAST110
Domaini1617 – 1731CUBInterPro annotationAdd BLAST115
Domaini1735 – 1847CUBInterPro annotationAdd BLAST113
Domaini1849 – 1960CUBInterPro annotationAdd BLAST112
Domaini1975 – 2088CUBInterPro annotationAdd BLAST114
Domaini2089 – 2210CUBInterPro annotationAdd BLAST122
Domaini2214 – 2331CUBInterPro annotationAdd BLAST118
Domaini2333 – 2445CUBInterPro annotationAdd BLAST113
Domaini2449 – 2562CUBInterPro annotationAdd BLAST114
Domaini2567 – 2684CUBInterPro annotationAdd BLAST118
Domaini2686 – 2798CUBInterPro annotationAdd BLAST113
Domaini2802 – 2916CUBInterPro annotationAdd BLAST115
Domaini2917 – 3032CUBInterPro annotationAdd BLAST116
Domaini3034 – 3147CUBInterPro annotationAdd BLAST114
Domaini3154 – 3271CUBInterPro annotationAdd BLAST118
Domaini3275 – 3392CUBInterPro annotationAdd BLAST118
Domaini3392 – 3504CUBInterPro annotationAdd BLAST113
Domaini3508 – 3620CUBInterPro annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 127Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Family and domain databases

CDDicd00041 CUB, 27 hits
Gene3Di2.60.120.290, 27 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 27 hits
PF00008 EGF, 3 hits
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00042 CUB, 27 hits
SM00181 EGF, 8 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF49854 SSF49854, 27 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01180 CUB, 27 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 3 hits

Sequencei

Sequence statusi: Complete.

A0A2U4B764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLFLWSLV ILLTFAESHG EAGGLALQRQ KRNTDLQQPR MTAERGNLVF
60 70 80 90 100
LTGSAQNIEF RTGSRGKIKL NDEDLGECLH QIQENKDDIT NLKRGAVGLP
110 120 130 140 150
QNISSQIHQL DSKLVDLERK FQRLQQTHDR KVCSSNPCQH GGTCLNLQDS
160 170 180 190 200
FFCICPSQWK GPLCSVDVNE CEIYSGTPLG CQNGATCINT EGSYSCLCSP
210 220 230 240 250
DTHGPQCASR YDDCEGGSQV RCVHGICEDL VRVQAGEPKY SCLCDAGWTA
260 270 280 290 300
PSNSTACTLD RDECSLWPPP CSALVQCFNT PGSFYCGACP AGWQGNGYIC
310 320 330 340 350
EDINECEISN GGCSVAPPVA CINTPGSYHC RPCPPGYQGD GRVCALIDLC
360 370 380 390 400
SVNNGGCHPL ASCSLVLGSL PVCTCLPGYT GSGYGPNGCV QLSNICLSHP
410 420 430 440 450
CLNGQCHETV SGYLCNCESG WAGVNCTENI NECLSNPCLN GGTCVDGVNA
460 470 480 490 500
FSCECTRFWT GFLCQIPQQV CGGSLSGMNG SFSYMSPNVG YVHDVNCFWV
510 520 530 540 550
IRTEEGKVLR ITFTLFRLES GNNCPHEFLQ IHDGDSSAAF QLGRFCGSIP
560 570 580 590 600
HHELLSSDNA LYFHFYSEHL RNERGFTVRW ETQPPECGGI LTGTYGSIKS
610 620 630 640 650
PGYPGKYPPG RDCVWKVITS PGLLITFTFG TLSLEHRDDC SKDYLEIRDG
660 670 680 690 700
PLHQDPVLGK FCTTLSVPPL QTTGPFARIH FHSDNQINDQ GFHITYLTSP
710 720 730 740 750
LDLQCGGNYT DPEGLLSADL SGPFTHNRQC IYTIRQPLGE QVQVNFTHVE
760 770 780 790 800
LEGQSGCSQS YIEVRDDQTL LGKVCGSETL SHIKSITNSI WIRLKIDASV
810 820 830 840 850
VRASFSAVYQ VACGGELTGE GVIRSPFYPN VYPGERICRW TIHQPQSQVV
860 870 880 890 900
LLNFTAFDTG SSAHCDTDYI EIGSSSILGS PENKKYCGTD IPSFITSVYN
910 920 930 940 950
FLHVIFVKSS SAENYGFMAK FSTAALACGK VLTESTGSIQ SPGHPNIYPH
960 970 980 990 1000
GVNCTWHVIV QPGHLIHLRF REFHLEFHYN CTKDYLEVYD TGSQTSLGRY
1010 1020 1030 1040 1050
CGKSIPPSLT SSDNSLMLTF VADSDLAYEG FLVNYEAIDA SAACLEDYTG
1060 1070 1080 1090 1100
ESGTFTSPNF PSNYPNNLEC IYRITVKTSQ QIALHFTNFS LEEAIGGTCV
1110 1120 1130 1140 1150
ADYVEIRNGG YETSPPLGQY CGSNPPPRII SHSNKLWLKF KSDFLGSGPG
1160 1170 1180 1190 1200
FSAYWDGSLT GCGGNLTTPT GMFTSPNYPM PYHHGSQCHW WLKSSHGSPF
1210 1220 1230 1240 1250
ELEFEDFHLE YHPNCTSDYL AVYDGPSTSS HLLTQLCGNE EPPVIRSSGD
1260 1270 1280 1290 1300
SVSLKLRTDE GQQGRGFLLK YHQTCENVVI VNQTYGILES IHYPNPYSVN
1310 1320 1330 1340 1350
QRCNWTIRAT TGNTVNYTFL AFELEHHTNC STDYLELYDG PRRMGRYCGA
1360 1370 1380 1390 1400
DIPPSGSTTG SKLQVLFYTD GVGYHEKGFQ MQWFIQGCGG ELSGDTGSFS
1410 1420 1430 1440 1450
SPGYPNRYPA NKECIWYIHT APGSSVQLTI HDFDVEYHAS CTFDVLEIYG
1460 1470 1480 1490 1500
GPDFHSPRIA QLCVQRSSEN PMQVSSTGSE LAIRFKTDWS INGRGFNISW
1510 1520 1530 1540 1550
RAVPGGCGGI FQAPSGEIHS PNYPSPYRSN TECTWVIQVE KHHRVLLNFT
1560 1570 1580 1590 1600
DFDLEPQDSC IMAFDGLSSA APRLAGVCGR QQLRNPFTSS GNSLFLRFQS
1610 1620 1630 1640 1650
GPSRQSRGFR AHFRQACGGY ILTDSVDTIS SPLFPANYPY NQNCSWIIQA
1660 1670 1680 1690 1700
RPPFNHITLS FSHFGLESST TCTRDFLEIL DGSRDDAPLR GRYCGPTMPH
1710 1720 1730 1740 1750
PITSFSNALT LRFVSDAIAN FGGFHATYAA STSACGGIFH MAEGIFNSPG
1760 1770 1780 1790 1800
YPEIYPSNVE CVWNIVSSPG NQLQLSFITF QVEESQDCSR DFVEIREGNA
1810 1820 1830 1840 1850
TGRLVGRYCG NVLPLNYSSI LGHILWVRFV SDGSGSGVGF QAAFTNIFGN
1860 1870 1880 1890 1900
DNIVGTQGKI ASPLWPGNYP HNSNYHWIVN VNESQVIHGR ILEMDMEATL
1910 1920 1930 1940 1950
NCYYDKLKVY DGAGIHSRLI GTYCGTQTGS LSSTRSSLTF QFSSDSSVSG
1960 1970 1980 1990 2000
KGFLLEWFAM NASVGPLPTI ATGACGGFLQ TGDAPVFLYS PGWPESYSNG
2010 2020 2030 2040 2050
ADCMWLIQAP DSTVELNILS LDIESHSTCS YDKLVIRDGD NSMAQELAVL
2060 2070 2080 2090 2100
CGREIPGPIR STGEHMVIHF TSDFSVTRAG FNASFHKSCG GYLHADRGII
2110 2120 2130 2140 2150
TSPGYAETYT PNLNCSWHVQ VQSGLTIAVH FEQPFQIPNR DSSCSQGDYL
2160 2170 2180 2190 2200
VLKNGPDISS PPLGPHGGNG RFCGSRPSST LFTSDNQMFV QFISDNSNEG
2210 2220 2230 2240 2250
RGFKITYEAK SLACGGNIYI HDADSAGYVT SPNHPSHYPQ HADCSWLIAA
2260 2270 2280 2290 2300
PPGKLIRLQF EDQFSVEATP NCTSNYLELR DGADSNAPVL SKFCGAHLPA
2310 2320 2330 2340 2350
SQLSSGELMY LRFRSDSSPT HVGFKAKYSI AECGGRVTGQ SGVIESSGYP
2360 2370 2380 2390 2400
TLPYADDLFC EWHLQGLSGH YLTIRFEGFS LQDSSGCERD FVEIWENHTS
2410 2420 2430 2440 2450
GNLLGRYCGN TIPDSIDTSG NVALVRFVTD GSLSASGFRL RFDSSVEACG
2460 2470 2480 2490 2500
GDLQGPAGTF TSPNYLNPNP HGWMCEWRIT VQEGQRVTLT FDNLRLEDHP
2510 2520 2530 2540 2550
FCSSEHVTVF NGIRSNSPQL EKLCSSVNGT NEIKSSGNTM KVVYFTDGSR
2560 2570 2580 2590 2600
PYGGFSASYT SSEDAVCGGS LTNSAVGNFT SPGYDGVSNY SRNLNCEWTL
2610 2620 2630 2640 2650
SNPHQGNSSI YIHFEDFYLE SHQDCQFDVL EFRAGNADGL LIWRLCGASE
2660 2670 2680 2690 2700
PSMPLVIPYP QVWIHFVTNE RVEHVGFHAQ YSFTDCGGVQ IGESGVISSP
2710 2720 2730 2740 2750
NYPASYDRLT HCSWLLEAPQ GHTITLTFSD FDIEAHSTCA WDAVTVRNGG
2760 2770 2780 2790 2800
SPGSPIIGHY CGSSNPRTIQ SGSNQLVVIF NTDRSVQNGG FYATWNTETL
2810 2820 2830 2840 2850
GCGGILHLDN GTIRSPHWPQ NFPENVRCSW TVITHQSKHL ELSFDNNFLI
2860 2870 2880 2890 2900
PSGDGQCRTS FVKVWAGTQE ADQSLLASSC GSVAPGPIIT PRNAFTAVFQ
2910 2920 2930 2940 2950
SQEVPAQGFS ASFVSRCGRN FTNPSGYIVS PNYPKQYDNN MNCTYIIEAS
2960 2970 2980 2990 3000
PLSLVLLTFV SFHLEARSTV TGSCVNDGVH IVRGYSLSST PLATLCGDES
3010 3020 3030 3040 3050
LSPVTTSGPM LLNFYSNAHT TDLGFKFSYR ITPCGGVFNL STGVIKSPFY
3060 3070 3080 3090 3100
SYSAYPNNMH CLYTITVRDD RVIQLKFNDF DVVSSTFCSQ DYLAVYDGSN
3110 3120 3130 3140 3150
ISDPLLGKFC GSSLPPGVKS SSSSMFLVFN TDSFQTARGW RISFWQTLGP
3160 3170 3180 3190 3200
QQGCGGYLTR SDGTFASPDS DSNGRYDKNL NCIWFMTAPV NKLIRLTFNT
3210 3220 3230 3240 3250
FALEAATSLQ RCIYDYVKLY DGDSENANLA GTFCGSTVPA PFISSGNFLT
3260 3270 3280 3290 3300
VQFVSDLTLE REGFNATYTI VDMPCGGTYN ATWTPQSISS PNSSDPAVPF
3310 3320 3330 3340 3350
SACTWVLEAP LHQQVMITVW ALALHSQDCD QNYLEFQDPP ESNGSPGIRF
3360 3370 3380 3390 3400
CGRNASAVPT FYSSMSTAIV TFKSEVFNIN SRVGFTYQIA DCNREYKKAF
3410 3420 3430 3440 3450
GNLRSPGWPG GYSSNVNCTV VLTAPHNHTI SLFFHSFDIE DSSDCTCDFL
3460 3470 3480 3490 3500
EVRNGSESTS PLLGMFCGTL LPNPIFSQSR ELYLRFKSDS ATSGRGYEII
3510 3520 3530 3540 3550
WTSSPSDCGG TLYGDSGAVT SPGYPGTYPN NTHCEWTIIA PAGRPVTVSF
3560 3570 3580 3590 3600
YFISIDDPGE CVQNYLLLYD GPDADSPSSG PYCGADTDIA PFVASSHRVF
3610 3620
IKFHAEYAAR PSAIQLTWAS
Length:3,620
Mass (Da):396,013
Last modified:July 18, 2018 - v1
Checksum:i452A9CBC48C7BB92
GO

Sequence databases

RefSeqiXP_019789065.1, XM_019933506.1

Genome annotation databases

GeneIDi101327585

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_019789065.1, XM_019933506.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101327585

Family and domain databases

CDDicd00041 CUB, 27 hits
Gene3Di2.60.120.290, 27 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 27 hits
PF00008 EGF, 3 hits
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00042 CUB, 27 hits
SM00181 EGF, 8 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF49854 SSF49854, 27 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01180 CUB, 27 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2U4B764_TURTR
AccessioniPrimary (citable) accession number: A0A2U4B764
Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: October 10, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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