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Protein
Submitted name:

cubilin

Gene

CUBN

Organism
Leptonychotes weddellii (Weddell seal)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cubilinImported
Gene namesi
Name:CUBNImported
OrganismiLeptonychotes weddellii (Weddell seal)Imported
Taxonomic identifieri9713 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaPhocidaeLeptonychotes
Proteomesi
  • UP000245341 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501547733221 – 3065Sequence analysisAdd BLAST3045

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi155 ↔ 164PROSITE-ProRule annotation
Disulfide bondi198 ↔ 207PROSITE-ProRule annotation
Disulfide bondi313 ↔ 330PROSITE-ProRule annotation
Disulfide bondi396 ↔ 406PROSITE-ProRule annotation
Disulfide bondi417 ↔ 426PROSITE-ProRule annotation
Disulfide bondi455 ↔ 464PROSITE-ProRule annotation
Disulfide bondi1361 ↔ 1388PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 165EGF-likeInterPro annotationAdd BLAST37
Domaini167 – 208EGF-likeInterPro annotationAdd BLAST42
Domaini260 – 301EGF-likeInterPro annotationAdd BLAST42
Domaini302 – 345EGF-likeInterPro annotationAdd BLAST44
Domaini346 – 382EGF-likeInterPro annotationAdd BLAST37
Domaini392 – 427EGF-likeInterPro annotationAdd BLAST36
Domaini429 – 465EGF-likeInterPro annotationAdd BLAST37
Domaini471 – 556CUBInterPro annotationAdd BLAST86
Domaini557 – 668CUBInterPro annotationAdd BLAST112
Domaini672 – 782CUBInterPro annotationAdd BLAST111
Domaini788 – 902CUBInterPro annotationAdd BLAST115
Domaini906 – 1018CUBInterPro annotationAdd BLAST113
Domaini1019 – 1130CUBInterPro annotationAdd BLAST112
Domaini1132 – 1247CUBInterPro annotationAdd BLAST116
Domaini1251 – 1360CUBInterPro annotationAdd BLAST110
Domaini1361 – 1475CUBInterPro annotationAdd BLAST115
Domaini1479 – 1591CUBInterPro annotationAdd BLAST113
Domaini1593 – 1704CUBInterPro annotationAdd BLAST112
Domaini1719 – 1832CUBInterPro annotationAdd BLAST114
Domaini1833 – 1954CUBInterPro annotationAdd BLAST122
Domaini1958 – 2075CUBInterPro annotationAdd BLAST118
Domaini2077 – 2188CUBInterPro annotationAdd BLAST112
Domaini2192 – 2305CUBInterPro annotationAdd BLAST114
Domaini2310 – 2427CUBInterPro annotationAdd BLAST118
Domaini2429 – 2541CUBInterPro annotationAdd BLAST113
Domaini2545 – 2716CUBInterPro annotationAdd BLAST172
Domaini2720 – 2837CUBInterPro annotationAdd BLAST118
Domaini2837 – 2949CUBInterPro annotationAdd BLAST113
Domaini2953 – 3065CUBInterPro annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 127Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Family and domain databases

CDDicd00041 CUB, 22 hits
Gene3Di2.60.120.290, 22 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 22 hits
PF00008 EGF, 3 hits
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00042 CUB, 22 hits
SM00181 EGF, 8 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF49854 SSF49854, 23 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01180 CUB, 22 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 3 hits

Sequencei

Sequence statusi: Complete.

A0A2U3XRG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSFLWSLV ILLTFAESNG GTGELELQRQ KRSTELQQPR MAAERGNLVF
60 70 80 90 100
LAGTAQNIEF RTGSLGKIKL NEEDLGECLH QIQRNKDDII DLKRSAVGLP
110 120 130 140 150
QNISSQIHQL NSKLVDMERK FQNLQQTVDR KVCSSNPCQN GGTCLNLHDS
160 170 180 190 200
FYCICPSQWK GPLCSVDVNE CAIYSGTPLG CQNGATCENT AGSYSCLCSP
210 220 230 240 250
ETHGPQCASR YDDCEGGSKE LCVHGICEDL VRVQADQPRY SCICDVGWTS
260 270 280 290 300
PLNGPACVLD IDECSLQHSP CSTLAQCFNT PGSFYCGACP TGWQGNGYSC
310 320 330 340 350
QDINECEINN GGCSVAPPVT CVNTFGSYHC QACPPGYQGN GRVCTLIDIC
360 370 380 390 400
SVSNGGCHPD ASCSSVLGSL PLCTCLPGYT GNGYGPNGCV QLSNICQSRP
410 420 430 440 450
CLNGQCIETV SGYLCKCESG WAGINCTENI NECLSNPCLN GGTCVDGINA
460 470 480 490 500
FSCECTRFWT GLLCQIPQQV CGGSLSGMSG SFSYMSPDVG YVHDVNCFWV
510 520 530 540 550
IRTEEGKVRD DQTLLGKVCG NETISNIKSI TNSIWIRLKI DASVVRASFR
560 570 580 590 600
AVYQVACGGE LTGEGVIRSP FYPNVYPGER ICRWTIHQPQ SQVVILNFTA
610 620 630 640 650
FEIESSTHCD TDYIEIGSSS ILGSPENKKY CGTDIPSFIT SVYNFLYVIF
660 670 680 690 700
VKSSSTENRG FMAKFSSADL ACGKILTEST GIIQSPGHPN IYPHGINCTW
710 720 730 740 750
HILVQPGHLI HLIFRVFHLE FHYNCTNDYL EVYDTGSETS LGRYCGKSIP
760 770 780 790 800
PSLTSSTNSL MLIFVADSDI AYEGFLINYE AIDASAACME DYTEESGTFT
810 820 830 840 850
SPNFPDNYPN NLKCIYRITV ETSQQIALHF TNFSLEEAIG GHCIGDFVEI
860 870 880 890 900
RDGGYESSPP LGTYCGSNPP PRIISHSNKL WLQFKSDFLG SGPGFSVYWD
910 920 930 940 950
GSLTGCGGNL TTPTGVFTSP NYPMPYYHSS ECYWRLKSSH GSPFELEFED
960 970 980 990 1000
FHLENHPNCM SDYLAVYDGP STSSHLLSQL CGNEKPPLIR SSGDSMFLKF
1010 1020 1030 1040 1050
RTDEGQQGGG FLAKYQQTCR NVVIVNRTYG ILESIHYPGP YSDNQRCNWT
1060 1070 1080 1090 1100
IQASIGNTVN YTFLAFELEN HINCSTDYLE LHDGPRRIGR YCGTDMPPTG
1110 1120 1130 1140 1150
STTGSKLQVL FYTDGVSHHE KGFQMQWFIH GCGGELSGTM GSFSSPGYPN
1160 1170 1180 1190 1200
TYPPNKECLW YITTAPGSSI QLTIHDFDVE YHVRCNFDVL EIYGGPDFHS
1210 1220 1230 1240 1250
PRISQLCAQR SSENPMQVSS TGNELAIRFK TDSSVNGRGF NASWQAVPGG
1260 1270 1280 1290 1300
CGGIFQAPNG EIHSPNYPSP YRRNTDCSWV IRVERNHRVL LNFTDFDLEP
1310 1320 1330 1340 1350
QDSCITAYDG LSATTTRLAR VCGRQLLANP ITSSGNSLFL RFQSGPSRQS
1360 1370 1380 1390 1400
RGFRAHFRQA CGSYILTDSF DTISSPLFPA KYPNNQNCSW IIQAQPPFNH
1410 1420 1430 1440 1450
ITLSFDHFGL ESSTTCTQDF IEILDGDYDD APLRGRYCGT SMPHPITSFS
1460 1470 1480 1490 1500
HALTLRFVSD SRANSEGFHA TYAASSSACG GTFHMAEGIF NSPGYPEVYP
1510 1520 1530 1540 1550
SNVECVWNIV SSPGNRLQLS FITFQLEDSR DCSRDFVEVR EGNATGPLVG
1560 1570 1580 1590 1600
RYCGNVLPLN YSSIVGHILW IRFVSDGSGS GTGFQATFTK IFGNDNIVGT
1610 1620 1630 1640 1650
HGKVASPLWP GRYPHNSNYQ WIVNVNASQV IHGRILEIDI EAAPGCYYDK
1660 1670 1680 1690 1700
LRIYDGHGVH SRLIGTYCGT QTTTFSSSRN SLTFQFSSDS SVTGKGFLLE
1710 1720 1730 1740 1750
WFAVNVSVGP LPTIATGACG GFLRTGDAPV FLFSPGWPES YSNNVDCMWL
1760 1770 1780 1790 1800
IQAPDSTVEL NILSLDIEAH RTCDYDKLVI RDGDSNLAPQ LAVLCGREIP
1810 1820 1830 1840 1850
GPIRSTGEYM FIRLTSDFSV TGAGFNASFH KSCGGYLHAD RGIITSPQYP
1860 1870 1880 1890 1900
ETYSPNLNCS WHVLVQSGLT IAVHFEQPFQ IPNGDSSCSQ GDYLVLKNGP
1910 1920 1930 1940 1950
DIYSPPLGLH GGNGHFCGSH PSSTLFTSDN QMFVQFISDA SNGGQGFKIK
1960 1970 1980 1990 2000
YEAKSLACGG NIYIHDVDSA GYVTSPGHPD NYPQHADCTW LLAAPPGKLI
2010 2020 2030 2040 2050
RLQFEDQFNI GETPNCTSNY LELRDGADSN APVLSKVCGR SLPRSQLSSG
2060 2070 2080 2090 2100
DVMYLRFRSD NSPTQVGFKI KYAIAHCGGR VTGQSGVIES GYPTLPYRDN
2110 2120 2130 2140 2150
LFCEWHLEGP SGHYLTIHFE DFNLQNSSGC EKDFVEIWEN HTSGSLLGRY
2160 2170 2180 2190 2200
CGNTIPDSID TSSNVALVRF VTDGSLTASG FRLQFESSME ECGGDLQGPT
2210 2220 2230 2240 2250
GTFTSPNYPN PNPHGRVCEW RITVQEGRRI TLTFNNLSLE ARPSCSSERV
2260 2270 2280 2290 2300
TIFNGIRSNS PQLEKLCSNV NVSDAIRSSG NTMKVVFFTD GSRPYGGFSA
2310 2320 2330 2340 2350
SYTSSEDAVC GGSLTHFPEG NFTSPGYNGV SNYSRNLNCE WTLSNPNQGN
2360 2370 2380 2390 2400
SSMYIQFEDF YLESHQDCQF DVLEFRASNA DGPLMWRLCG PSKPTVPLVT
2410 2420 2430 2440 2450
PYPQVWIHFV TNEHVEHVGF HAEYSFTDCG GIQLGESGVI TSPNYPASYD
2460 2470 2480 2490 2500
SLTHCSWLLE APEGHTITLT FSDFDIEAHA TCVWDSVTVR NGGSPGSPII
2510 2520 2530 2540 2550
GQYCGSSNPG TIQSGSNQLV VIFNSDHSVQ NGGFYATWNT QTLGCGGNFT
2560 2570 2580 2590 2600
NPSGYILSPN YPKQYDNNMN CTYIIEADPL SLVFLTFVSF HLEGPRQGCG
2610 2620 2630 2640 2650
GYLTGSNNTF ASPDSDSNGR YDKNLNCIWF ITAPVNKLIK LTFSTFALEA
2660 2670 2680 2690 2700
QSILQRCIYD YVKLYDGDSE NANLAGTFCG STVPAPFISS GNFLTVQFVS
2710 2720 2730 2740 2750
DATLEREGFN ATYTLVDMPC GGTYNATWTP QSISSPNSSN PEILFSMCTW
2760 2770 2780 2790 2800
VLEAPPHQQV KITVWALQLL SQDCDQNYLE FQDSPESHAN PGLLVCGRNA
2810 2820 2830 2840 2850
SATPTFYSSG STAIVIFKSE VLSGNSRVGF TYQIAGCNRD YNKAFGNLKS
2860 2870 2880 2890 2900
PGWPDNYDNN LDCTVILTAP QNHTISLFFH SFGIEDSSEC THDFLEVRNG
2910 2920 2930 2940 2950
SDSSSPLLGT YCGTLLPNPI FSQNNELYLR FKSDRATSSH GYEILWTSSP
2960 2970 2980 2990 3000
SGCGGTLFGD SGSFTSPSYP GTYPNNTHCE WAITAPAGRP VTISFYFISI
3010 3020 3030 3040 3050
DDPGDCVQNY LILYSGPDAN SPSSGPYCGA DTNIAPFMAS SPRVFIKFHA
3060
EYAVHPSAFR LTWDS
Length:3,065
Mass (Da):335,503
Last modified:July 18, 2018 - v1
Checksum:i6FBB0C868ECAD53F
GO

Sequence databases

RefSeqiXP_006734061.1, XM_006733998.1

Genome annotation databases

GeneIDi102750726

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_006734061.1, XM_006733998.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102750726

Family and domain databases

CDDicd00041 CUB, 22 hits
Gene3Di2.60.120.290, 22 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 22 hits
PF00008 EGF, 3 hits
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00042 CUB, 22 hits
SM00181 EGF, 8 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF49854 SSF49854, 23 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01180 CUB, 22 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2U3XRG8_LEPWE
AccessioniPrimary (citable) accession number: A0A2U3XRG8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: October 10, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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