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Protein

Sodium channel protein

Gene

SCN5A

Organism
Odobenus rosmarus divergens (Pacific walrus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:SCN5AImported
OrganismiOdobenus rosmarus divergens (Pacific walrus)Imported
Taxonomic identifieri9708 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaOdobenidaeOdobenus
Proteomesi
  • UP000245340 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 149HelicalUniRule annotationAdd BLAST23
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei388 – 416HelicalUniRule annotationAdd BLAST29
Transmembranei838 – 861HelicalUniRule annotationAdd BLAST24
Transmembranei881 – 898HelicalUniRule annotationAdd BLAST18
Transmembranei918 – 941HelicalUniRule annotationAdd BLAST24
Transmembranei1151 – 1170HelicalUniRule annotationAdd BLAST20
Transmembranei1191 – 1207HelicalUniRule annotationAdd BLAST17
Transmembranei1219 – 1240HelicalUniRule annotationAdd BLAST22
Transmembranei1268 – 1294HelicalUniRule annotationAdd BLAST27
Transmembranei1390 – 1416HelicalUniRule annotationAdd BLAST27
Transmembranei1475 – 1493HelicalUniRule annotationAdd BLAST19
Transmembranei1505 – 1523HelicalUniRule annotationAdd BLAST19
Transmembranei1535 – 1555HelicalUniRule annotationAdd BLAST21
Transmembranei1592 – 1620HelicalUniRule annotationAdd BLAST29
Transmembranei1695 – 1718HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 422Ion_transInterPro annotationAdd BLAST293
Domaini478 – 667Na_trans_cytoplInterPro annotationAdd BLAST190
Domaini718 – 945Ion_transInterPro annotationAdd BLAST228
Domaini955 – 1146Na_trans_assocInterPro annotationAdd BLAST192
Domaini1150 – 1425Ion_transInterPro annotationAdd BLAST276
Domaini1474 – 1728Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili413 – 451Sequence analysisAdd BLAST39
Coiled coili958 – 978Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A2U3WSN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSAASQ ESREGLPEEE
60 70 80 90 100
APQPQLDLQA SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK
110 120 130 140 150
TIFRFSATNA LYVLSPFHPV RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ
160 170 180 190 200
HDPPPWTKYV EYTFTAIYTF ESLVKILARG FCLHAFTFLR DPWNWLDFSV
210 220 230 240 250
IVMAYVSENI KLGNLSALRT FRVLRALKTI SVIPGLKTIV GALIQSVKKL
260 270 280 290 300
ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNDT NGSVEADGLV
310 320 330 340 350
WESLDVYLSN PENYLLKNGT SDVLLCGNSS DAGTCPEGYR CLKAGDNPDH
360 370 380 390 400
GYTSFDSFAW AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG
410 420 430 440 450
SFYLVNLILA VVAMAYEEQN QATIAETEEK EKRFQEAMEM LKKEHEALTI
460 470 480 490 500
RGVDTVSRSS LEMSPLAPVT THERRSKRRK RMSLGTEECG DDRFPKSDSE
510 520 530 540 550
DGPRAMNRLS STHGLSRTSM KPRSSRGSIF TFRRRDLGSE TDFADDENST
560 570 580 590 600
AGDSESHRTS LLVPWPLRRP SAQGQLSPGT SAPGHTLNGK RNSTVDCNGV
610 620 630 640 650
VSLLGAGDPE ATSPGSHLLH PVILDRPPDT TTPSEEPGRP QILNAQAPCL
660 670 680 690 700
DGFEEPGERR RALSAVSVLT SALEELEESH RKCPPCWNRC AQRYLIWECC
710 720 730 740 750
PLWISIKQRV KFVVMDPFAD LTITMCIVLN TLFMALEHYN MTTEFEEMLQ
760 770 780 790 800
VGNLVFTGIF TAEMTFKIIA LDPYYYFQEG WNIFDSIIVI LSLMELGLSR
810 820 830 840 850
MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG NLTLVLAIIV
860 870 880 890 900
FIFAVVGMQL FGKNYSEQRY RISDSGLLPR WHMMDFFHAF LIIFRILCGE
910 920 930 940 950
WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT
960 970 980 990 1000
APDDDGEMNN LQLALARIQR GLRFLKRTTW DCALLQRRPQ KPAALAVHGQ
1010 1020 1030 1040 1050
LPSCVATSSP PLPPESEKVP LARKETRFEE DKQPGQGTPR DTEPVCVPIA
1060 1070 1080 1090 1100
VAESDTDDQE EDEENSLGTE EESSKQTHED SCSEGSTADM TNTADLLEQI
1110 1120 1130 1140 1150
PDLGEDVKDP ENCFTEGCVR RCPCCAVDTT QGPGKVWWRL RKTCYRIVEH
1160 1170 1180 1190 1200
SWFETFIIFM ILLSSGALAF EDIYLEERKT IKVLLEYADK MFTYVFVLEM
1210 1220 1230 1240 1250
LLKWVAYGFK KYFTNAWCWL DFLIVDVSLI SLVANTLGFA EMGPIKSLRT
1260 1270 1280 1290 1300
LRALRPLRAL SRFEGMRVVV NALVGAIPSI MNVLLVCLIF WLIFSIMGVN
1310 1320 1330 1340 1350
LFAGKFGRCI NQTEGDLPLN YTIVNNKSDC ESFNVTGELY WTKVKVNFDN
1360 1370 1380 1390 1400
VGAGYLALLQ VATFKGWMDI MYAAVDSRGY EEQPQWEYNL YMYIYFVIFI
1410 1420 1430 1440 1450
IFGSFFTLNL FIGVIIDNFN QQKKKLGGQD IFMTEEQKKY YNAMKKLGSK
1460 1470 1480 1490 1500
KPQKPIPRPL NKYQGFLFDI VTKQAFDVTI MFLICLNMVT MMVETDDQSP
1510 1520 1530 1540 1550
EKVNILAKIN LLFVAIFTGE CIIKMAALRH YYFTNSWNIF DFVVVILSIV
1560 1570 1580 1590 1600
GTVLSDIIQK YFFSPTLFRV IRLARIGRIL RLIRGAKGIR TLLFALMMSL
1610 1620 1630 1640 1650
PALFNIGLLL FLVMFIYSIF GMANFAYVKW EAGIDDMFNF QTFANSMLCL
1660 1670 1680 1690 1700
FQITTSAGWD GLLSPILNTG PPYCDPNLPN SNGSRGNCGS PAVGILFFTT
1710 1720 1730 1740 1750
YIIISFLIVV NMYIAIILEN FSVATEESTE PLSEDDFDMF YEIWEKFDPE
1760 1770 1780 1790 1800
ATQFIEYSAL SDFADALSEP LRIAKPNQIS LINMDLPMVS GDRIHCMDIL
1810 1820 1830 1840 1850
FAFTKRVLGE SGEMDALKIQ MEEKFMAANP SKISYEPITT TLRRKHEEVS
1860 1870 1880 1890 1900
ATIIQRAFRR HLLQRSMKHA SFLFRQQAGS SGLSDEDAPE QEGLIAYMMN
1910 1920 1930 1940 1950
ENFSRRLGPP SSSSVSSTSF PPSYDSVTRA TSDNPQVRVS DYSRSEDLAD
1960
FPPSPDRDRE SIV
Length:1,963
Mass (Da):221,843
Last modified:July 18, 2018 - v1
Checksum:i1803560E0239A87C
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2U3WSM7A0A2U3WSM7_ODORO
Sodium channel protein
SCN5A
2,015Annotation score:
A0A2U3WSY3A0A2U3WSY3_ODORO
Sodium channel protein
SCN5A
2,014Annotation score:
A0A2U3ZST7A0A2U3ZST7_ODORO
Sodium channel protein
SCN5A
1,996Annotation score:
A0A2U3WSP7A0A2U3WSP7_ODORO
Sodium channel protein
SCN5A
1,982Annotation score:
A0A2U3ZST8A0A2U3ZST8_ODORO
Sodium channel protein
SCN5A
2,015Annotation score:
A0A2U3WSP3A0A2U3WSP3_ODORO
Sodium channel protein
SCN5A
1,997Annotation score:

Sequence databases

RefSeqiXP_004412363.1, XM_004412306.1

Genome annotation databases

GeneIDi101385643

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_004412363.1, XM_004412306.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101385643

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008053 Na_channel_a5su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01666 NACHANNEL5
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2U3WSN9_ODORO
AccessioniPrimary (citable) accession number: A0A2U3WSN9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: November 7, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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