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Protein
Submitted name:

gamma-aminobutyric acid receptor subunit alpha-2

Gene

GABRA2

Organism
Odobenus rosmarus divergens (Pacific walrus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
gamma-aminobutyric acid receptor subunit alpha-2Imported
Gene namesi
Name:GABRA2Imported
OrganismiOdobenus rosmarus divergens (Pacific walrus)Imported
Taxonomic identifieri9708 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaOdobenidaeOdobenus
Proteomesi
  • UP000245340 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei272 – 296HelicalSequence analysisAdd BLAST25
Transmembranei303 – 322HelicalSequence analysisAdd BLAST20
Transmembranei337 – 359HelicalSequence analysisAdd BLAST23
Transmembranei445 – 463HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 271Neur_chan_LBDInterPro annotationAdd BLAST207
Domaini279 – 362Neur_chan_membInterPro annotationAdd BLAST84

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KOiK05175

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005432 GABBAa2_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF218 PTHR18945:SF218, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01615 GABAARALPHA2
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2U3VMS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVELNVILSV FYFSSMALQR VAMKTKLNTY NMQLLLLLFL LWDPARLVLA
60 70 80 90 100
NIQEDEAKNN ITIFTRILDR LLDGYDNRLR PGLGDSITEV FTNIYVTSFG
110 120 130 140 150
PVSDTDMEYT IDVFFRQKWK DERLKFKGPM NILRLNNLMA SKIWTPDTFF
160 170 180 190 200
HNGKKSVAHN MTMPNKLLRI QDDGTLLYTM RLTVQAECPM HLEDFPMDAH
210 220 230 240 250
SCPLKFGSYA YTTSEVTYIW TYNASDSVQV APDGSRLNQY DLLGQSIGKE
260 270 280 290 300
TIKSSTGEYT VMTAHFHLKR KIGYFVIQTY LPCIMTVILS QVSFWLNRES
310 320 330 340 350
VPARTVFGVT TVLTMTTLSI SARNSLPKVA YATAMDWFIA VCYAFVFSAL
360 370 380 390 400
IEFATVNYFT KRGWAWDGKS VVNDKKKEKA SVMIQNNAYA VAVANYAPNL
410 420 430 440 450
SKDPVLSTIS KSATTPEPNK KPENKPAEAK KTFNSVSKID RMSRIVFPVL
460 470
FGTFNLVYWA TYLNREPVLG VSP
Length:473
Mass (Da):53,774
Last modified:July 18, 2018 - v1
Checksum:i06B86B02B2FFE346
GO

Sequence databases

RefSeqiXP_004396367.1, XM_004396310.1

Genome annotation databases

GeneIDi101384124
KEGGioro:101384124

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_004396367.1, XM_004396310.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101384124
KEGGioro:101384124

Phylogenomic databases

KOiK05175

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005432 GABBAa2_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF218 PTHR18945:SF218, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01615 GABAARALPHA2
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2U3VMS3_ODORO
AccessioniPrimary (citable) accession number: A0A2U3VMS3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: November 7, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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