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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Paraburkholderia silvatlantica
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi390 – 397ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processLipid transportUniRule annotationSAAS annotation, Transport
LigandATP-bindingUniRule annotationSAAS annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
ORF Names:C7411_12175Imported, C7413_12075Imported
OrganismiParaburkholderia silvatlanticaImported
Taxonomic identifieri321895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000248102 Componenti: Unassembled WGS sequence
  • UP000245407 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 56HelicalSequence analysisAdd BLAST24
Transmembranei76 – 103HelicalSequence analysisAdd BLAST28
Transmembranei146 – 168HelicalSequence analysisAdd BLAST23
Transmembranei174 – 193HelicalSequence analysisAdd BLAST20
Transmembranei256 – 283HelicalSequence analysisAdd BLAST28
Transmembranei295 – 313HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell inner membraneSAAS annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 321ABC transmembrane type-1InterPro annotationAdd BLAST284
Domaini353 – 590ABC transporterInterPro annotationAdd BLAST238

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili193 – 220Sequence analysisAdd BLAST28

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.UniRule annotation

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011917 ABC_transpr_lipidA
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02203 MsbA_lipidA, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51239 MSBA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2U1A5Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKPTLSKP IGSGEASSPV VVLRRLWPYV LPLIWVLLGA VVAMAVSAGT
60 70 80 90 100
DAAIPALLKP LLDKGFGAHA NDKAKWFVPI AVIGLALVRG VSQYASGYLL
110 120 130 140 150
AYVSNKILLE LRLKMFDRMI HTSVAFFQRE TASTVINAIV FEVNQILNVL
160 170 180 190 200
LSVLVTLVRD SLTVLFLLGY LFYLNWRLTL IVAVLLPGIG WLVGKINRRL
210 220 230 240 250
RRLNREHQML TNELSYIVEE TVGGYKVVKV HNGEQYEMSR FSAMSRRLRG
260 270 280 290 300
YSMRMIVSGG LAQPLTQFLA SIALAVVITI AVVQSSTDQT TVGGFVAFVT
310 320 330 340 350
SMLLIISPLK HLMDVNQPLQ RGMTAAELIF GLIDEPAEPA GGGRRLERAT
360 370 380 390 400
GAVEFRDVSF NYSSNGTHNR HTLDQVSFKV APGEMVALAG PSGSGKTTLV
410 420 430 440 450
NLLPRFFDPT GGEILVDGVA LPEYGIHALR SQIAMVSQDV VLFNDTVANN
460 470 480 490 500
VAYGQTMEPE RVRAALHAAN LSDTVDAMPD GIETLVGDNG MRLSGGQRQR
510 520 530 540 550
LAIARAIYKD APILILDEAT SALDSESERH VQAALETLMK GRTTLVIAHR
560 570 580 590
LSTIERANRI LVLDAGRIVE SGSHRELLAQ GGLYAHLHRI QFQQNAA
Length:597
Mass (Da):65,018
Last modified:July 18, 2018 - v1
Checksum:i90731B538D047E39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
QEOL01000021 Genomic DNA Translation: PVY27026.1
QIMG01000020 Genomic DNA Translation: PXW33302.1

Similar proteinsi

Entry informationi

Entry nameiA0A2U1A5Q5_9BURK
AccessioniPrimary (citable) accession number: A0A2U1A5Q5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: September 12, 2018
This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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