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Protein

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Gene

mtnN

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine.UniRule annotationSAAS annotation
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine.UniRule annotationSAAS annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route).UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (pfs), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN), 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN)
  2. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11Proton acceptorUniRule annotation1
Binding sitei77Substrate; via amide nitrogenUniRule annotation1
Binding sitei151Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1
Active sitei196Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseImported, Hydrolase
Biological processAmino-acid biosynthesis, Methionine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00904;UER00871

Names & Taxonomyi

Protein namesi
Recommended name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidaseUniRule annotation (EC:3.2.2.9UniRule annotation)
Short name:
MTA/SAH nucleosidaseUniRule annotation
Short name:
MTANUniRule annotation
Alternative name(s):
5'-methylthioadenosine nucleosidaseUniRule annotation
Short name:
MTA nucleosidaseUniRule annotation
S-adenosylhomocysteine nucleosidaseUniRule annotation
Short name:
AdoHcy nucleosidaseUniRule annotation
Short name:
SAH nucleosidaseUniRule annotation
Short name:
SRH nucleosidaseUniRule annotation
Gene namesi
Name:mtnNUniRule annotation
ORF Names:CSC83_07585Imported, CSC87_08935Imported
OrganismiStaphylococcus aureusImported
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000239144 Componenti: Unassembled WGS sequence
  • UP000239106 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 225PNP_UDP_1InterPro annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 173Substrate bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 25Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_01684 Salvage_MtnN, 1 hit
InterProiView protein in InterPro
IPR010049 MTA_SAH_Nsdase
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01704 MTA/SAH-Nsdase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2S6DEF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGIIGAMEE EVTILKNKLT QLSEISVAHV KFYTGILKDR EVVITQSGIG
60 70 80 90 100
KVNAAISTTL LINKFKPDII INTGSAGALD ESLNVGDVLI SDDVKYHDAD
110 120 130 140 150
ATAFGYEYGQ VPQMPVAFQS SKPLIEKVSQ VVQQQQLTAK VGLIVSGDSF
160 170 180 190 200
IGSIEQRQKI KKAFPNAMAV EMEATAIAQT CYQFNVPFVV VRAVSDLANG
210 220
EAEMSFEAFL EKAAVSSSQT VEALVSQL
Length:228
Mass (Da):24,548
Last modified:July 18, 2018 - v1
Checksum:iC4DC4AA75D98062E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDUY01000095 Genomic DNA Translation: PPJ94351.1
PDVL01000097 Genomic DNA Translation: PPK14539.1
RefSeqiWP_000579272.1, NZ_PYBG01000003.1

Similar proteinsi

Entry informationi

Entry nameiA0A2S6DEF6_STAAU
AccessioniPrimary (citable) accession number: A0A2S6DEF6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: September 12, 2018
This is version 2 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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