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Entry version 9 (12 Aug 2020)
Sequence version 1 (18 Jul 2018)
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Protein

Reverse transcriptase

Gene

Tf2-1_5

Organism
Sipha flava (yellow sugarcane aphid)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reverse transcriptaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tf2-1_5Imported
ORF Names:g.77769Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSipha flava (yellow sugarcane aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri143950 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeSipha

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini362 – 377CCHC-typeInterPro annotationAdd BLAST16
Domaini425 – 505Peptidase A2InterPro annotationAdd BLAST81
Domaini622 – 802Reverse transcriptaseInterPro annotationAdd BLAST181

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 67DisorderedSequence analysisAdd BLAST67
Regioni289 – 328DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16PolarSequence analysisAdd BLAST16
Compositional biasi26 – 67PolarSequence analysisAdd BLAST42
Compositional biasi289 – 305PolarSequence analysisAdd BLAST17
Compositional biasi306 – 321PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR041588, Integrase_H2C2
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom
IPR041577, RT_RNaseH_2
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF17919, RT_RNaseH_2, 1 hit
PF00078, RVT_1, 1 hit
PF00098, zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343, ZnF_C2HC, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50630, SSF50630, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2S2R3T0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENSSSTTS ALTTGHEVLS PRRLRNGSVL PSSSDVISVT QSNRAQHSNE
60 70 80 90 100
GTDSHQTSSV LPQSHPVPVD NQLLTNALLS LMEQNKVLLS KLVNDSTSPV
110 120 130 140 150
SDNIVPLQSS SRIPNNGYYV MPDFNHSLVN FSGRESNTEA RAWLNSIESV
160 170 180 190 200
AKLQNWPDNF KLETVRSKLI GPSHNWYVGR TFSNWTSFVD QFTNTFVGNE
210 220 230 240 250
LCTVDRVKKM SNRVQLKGEC VIEYFHHKSR LCREILLPFQ EAKMQIIEGL
260 270 280 290 300
YHHDMCNYLM ARTHMSEDDL LSDINSFNNL RNARSSRFWP NETTKSSSKN
310 320 330 340 350
NAVPFNRRMD NKDHDTVQRL PSDTKSRAPN NISNVTCHRC GVKGHIAPAC
360 370 380 390 400
TVKVKRNENR SCFRCHSHGH LARDCPQNKN NQLPASQLND HGENVSILEK
410 420 430 440 450
PSHDIVPPYT LSAKIVYPNG NYSSITALID TGSPVSLLKS MVVSYASGIK
460 470 480 490 500
PPPSGLMGIN GSMLNITDEF FADLHHVDLD MPINLKFRVV PDSTIQTDCL
510 520 530 540 550
LGRNFLAHPR VNLSVINGQF IINFTQTDSI PFNEILSLDF DLNNYSELDI
560 570 580 590 600
DLDINDKLSN DVITSIKKIY INNYVKHSAQ SSDDDRPEMH IQLKAHISFY
610 620 630 640 650
FRPRRLSFYE KEKLQIILDD MLAKQIIRPS KSEYSSPIVL VKKKNGDLRL
660 670 680 690 700
CVDYRELNKH IIKDRYPLPL IDDNLDLLRG KKYFTCFDLK DGFHHIHVGQ
710 720 730 740 750
DSIKYTSFTT PLGQFEYLKL PFGLATGPAC FSRFIKNIFD EFIRKKEVIV
760 770 780 790 800
YFDDIMVATE TIDEHLDVLA RILTTMKNKK LEIRLDKTQF LKSEVIYLGY
810 820 830 840 850
HVSADGIQPN PKNVAIIDNY PIPSNQKELH SFIGLASYFR RFIPNFALLA
860 870 880 890 900
QPLYKLLKKN VIYEFGEEQL KSFDQIKSKL NAQPLLSIYD PNAPTELHCD
910 920 930 940 950
ASNQGYGAIL LQRQSDNKFH PVFFYSHRTT DVESRYHSYE LEMLAIVNAV
960 970 980 990 1000
KRFHIYLQGI QFKIVTDCNS ITLTLHKKDI NPRIARWTLF LQNYSYEIEH
1010 1020 1030 1040 1050
RPGSKMQHVD ALSRCRHILV LEGCTFNQTL AVRQSTDPEI KNLIKTLEKT
1060 1070 1080 1090 1100
EHPLFEMRNG LVYRKNGNRL LFYVPAGMYE QIIRTCHDDM CHIGVNRTIE
1110 1120 1130 1140 1150
FIKQVYWFPK LAEHVKKYIK NCLKCIIFSP KEGKVEGLLN IIDKGNKPFH
1160 1170 1180 1190 1200
TIHIDHYGPL NRTRNNFKYI LVIVDAFSKF LNLYPVRCAI KIFCQFLSRT

LNLCHA
Length:1,206
Mass (Da):138,384
Last modified:July 18, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF28AB8B737AFAC0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GGMS01015422 Transcribed RNA Translation: MBY84625.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GGMS01015422 Transcribed RNA Translation: MBY84625.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 2 hits
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR041588, Integrase_H2C2
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom
IPR041577, RT_RNaseH_2
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PfamiView protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF17919, RT_RNaseH_2, 1 hit
PF00078, RVT_1, 1 hit
PF00098, zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 2 hits
SUPFAMiSSF50630, SSF50630, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2S2R3T0_9HEMI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2S2R3T0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 18, 2018
Last sequence update: July 18, 2018
Last modified: August 12, 2020
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Transposable elementARBA annotation
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