UniProtKB - A0A2R9BL62 (A0A2R9BL62_PANPA)
Protein
Submitted name:
Uncharacterized protein
Gene
ADAM17
Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- integrin binding Source: Ensembl
- interleukin-6 receptor binding Source: Ensembl
- metalloendopeptidase activity Source: Ensembl
- Notch binding Source: Ensembl
- PDZ domain binding Source: Ensembl
- SH3 domain binding Source: UniProtKB-KW
GO - Biological processi
- cell adhesion mediated by integrin Source: Ensembl
- cellular response to high density lipoprotein particle stimulus Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- epidermal growth factor receptor signaling pathway Source: Ensembl
- membrane protein ectodomain proteolysis Source: Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- Notch receptor processing Source: Ensembl
- positive regulation of blood vessel endothelial cell migration Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- positive regulation of chemokine production Source: Ensembl
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
- positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
- positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- positive regulation of T cell chemotaxis Source: Ensembl
- positive regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
- positive regulation of vascular endothelial cell proliferation Source: Ensembl
- receptor transactivation Source: Ensembl
- response to hypoxia Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- wound healing, spreading of epidermal cells Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Uncharacterized proteinImported |
Gene namesi | Name:ADAM17Imported |
Organismi | Pan paniscus (Pygmy chimpanzee) (Bonobo)Imported |
Taxonomic identifieri | 9597 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- apical plasma membrane Source: Ensembl
- integral component of plasma membrane Source: Ensembl
- ruffle membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- cell-cell junction Source: Ensembl
- focal adhesion Source: Ensembl
- membrane raft Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 672 – 694 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5015319142 | 18 – 824 | Sequence analysisAdd BLAST | 807 |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotation, Disulfide bondARBA annotationInteractioni
GO - Molecular functioni
- integrin binding Source: Ensembl
- interleukin-6 receptor binding Source: Ensembl
- Notch binding Source: Ensembl
- PDZ domain binding Source: Ensembl
- SH3 domain binding Source: UniProtKB-KW
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 223 – 474 | Peptidase M12BInterPro annotationAdd BLAST | 252 | |
Domaini | 475 – 563 | DisintegrinInterPro annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 732 – 824 | DisorderedSequence analysisAdd BLAST | 93 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 734 – 748 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 757 – 780 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 795 – 824 | PolyampholyteSequence analysisAdd BLAST | 30 |
Keywords - Domaini
SH3-bindingARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155443 |
OMAi | FYHGRVF |
Family and domain databases
CDDi | cd14246, ADAM17_MPD, 1 hit cd04270, ZnMc_TACE_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR032029, ADAM17_MPD IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF16698, ADAM17_MPD, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A2R9BL62-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRQSLLFLTS VVPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI
60 70 80 90 100
QQHSVRKRDL QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKVVVVD
110 120 130 140 150
GKNESEYTVK WQDFFTGHVV GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE
160 170 180 190 200
PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS PKVCGYLKVD NEELLPKGLV
210 220 230 240 250
DREPPEELVH RVKRRADPDP MKNTCKLLVV ADHRFYRYMG RGEESTTTNY
260 270 280 290 300
LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM
310 320 330 340 350
AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL
360 370 380 390 400
AYVGSPRANS HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD
410 420 430 440 450
LVTTHELGHN FGAEHDPDGL AECAPNEDQG GKYVMYPIAV SGDHENNKMF
460 470 480 490 500
SNCSKQSIYK TIESKAQECF QERSNKVCGN SRVDEGEECD PGIMYLNNDT
510 520 530 540 550
CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA TCKGVSYCTG
560 570 580 590 600
NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC
610 620 630 640 650
KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE
660 670 680 690 700
RFWDFIDQLS INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK
710 720 730 740 750
QYESLSLFHP SNVEMLSSMD SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA
760 770 780 790 800
APKLDHQRMD TIQEDPSTDS HMDEDGFEKD PFPNSSTAAK SFEDLTDHPV
810 820
TRSEKAASFK LQRQNRVDSK ETEC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R9BLB8 | A0A2R9BLB8_PANPA | Pep_M12B_propep domain-containing p... | ADAM17 | 285 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJFE02094563 Genomic DNA No translation available. AJFE02094564 Genomic DNA No translation available. AJFE02094565 Genomic DNA No translation available. AJFE02094566 Genomic DNA No translation available. AJFE02094567 Genomic DNA No translation available. AJFE02094568 Genomic DNA No translation available. AJFE02094569 Genomic DNA No translation available. AJFE02094570 Genomic DNA No translation available. |
RefSeqi | XP_003826994.1, XM_003826946.2 |
Genome annotation databases
Ensembli | ENSPPAT00000053290; ENSPPAP00000030429; ENSPPAG00000038185 |
GeneIDi | 100988650 |
KEGGi | pps:100988650 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJFE02094563 Genomic DNA No translation available. AJFE02094564 Genomic DNA No translation available. AJFE02094565 Genomic DNA No translation available. AJFE02094566 Genomic DNA No translation available. AJFE02094567 Genomic DNA No translation available. AJFE02094568 Genomic DNA No translation available. AJFE02094569 Genomic DNA No translation available. AJFE02094570 Genomic DNA No translation available. |
RefSeqi | XP_003826994.1, XM_003826946.2 |
3D structure databases
SMRi | A0A2R9BL62 |
ModBasei | Search... |
Genome annotation databases
Ensembli | ENSPPAT00000053290; ENSPPAP00000030429; ENSPPAG00000038185 |
GeneIDi | 100988650 |
KEGGi | pps:100988650 |
Organism-specific databases
CTDi | 6868 |
Phylogenomic databases
GeneTreei | ENSGT00940000155443 |
OMAi | FYHGRVF |
Family and domain databases
CDDi | cd14246, ADAM17_MPD, 1 hit cd04270, ZnMc_TACE_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR034025, ADAM10_ADAM17 IPR032029, ADAM17_MPD IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF16698, ADAM17_MPD, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R9BL62_PANPA | |
Accessioni | A0A2R9BL62Primary (citable) accession number: A0A2R9BL62 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | February 10, 2021 | |
This is version 17 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |