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Entry version 19 (02 Jun 2021)
Sequence version 1 (20 Jun 2018)
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Protein

Histone-lysine N-methyltransferase

Gene
N/A
Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3769S-adenosyl-L-methionineUniRule annotation1
Binding sitei3771S-adenosyl-L-methionineUniRule annotation1
Binding sitei3813S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3839ZincUniRule annotation1
Metal bindingi3887ZincUniRule annotation1
Binding sitei3888S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3889ZincUniRule annotation1
Metal bindingi3894ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1074 – 1122CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9597 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000240080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1074 – 1122CXXC-typeInterPro annotationAdd BLAST49
Domaini1358 – 1409PHD-typeInterPro annotationAdd BLAST52
Domaini1406 – 1460PHD-typeInterPro annotationAdd BLAST55
Domaini1493 – 1557PHD-typeInterPro annotationAdd BLAST65
Domaini1633 – 1678BromoInterPro annotationAdd BLAST46
Domaini1800 – 1908PHD-typeInterPro annotationAdd BLAST109
Domaini1948 – 2004FYR N-terminalInterPro annotationAdd BLAST57
Domaini3596 – 3677FYR C-terminalInterPro annotationAdd BLAST82
Domaini3759 – 3875SETInterPro annotationAdd BLAST117
Domaini3883 – 3899Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni56 – 178DisorderedSequence analysisAdd BLAST123
Regioni228 – 271DisorderedSequence analysisAdd BLAST44
Regioni366 – 529DisorderedSequence analysisAdd BLAST164
Regioni640 – 875DisorderedSequence analysisAdd BLAST236
Regioni897 – 930DisorderedSequence analysisAdd BLAST34
Regioni965 – 993DisorderedSequence analysisAdd BLAST29
Regioni1032 – 1093DisorderedSequence analysisAdd BLAST62
Regioni1127 – 1319DisorderedSequence analysisAdd BLAST193
Regioni1593 – 1643DisorderedSequence analysisAdd BLAST51
Regioni1711 – 1799DisorderedSequence analysisAdd BLAST89
Regioni2011 – 2063DisorderedSequence analysisAdd BLAST53
Regioni2075 – 2152DisorderedSequence analysisAdd BLAST78
Regioni2178 – 2266DisorderedSequence analysisAdd BLAST89
Regioni2298 – 2390DisorderedSequence analysisAdd BLAST93
Regioni2405 – 2548DisorderedSequence analysisAdd BLAST144
Regioni2575 – 2605DisorderedSequence analysisAdd BLAST31
Regioni2643 – 2776DisorderedSequence analysisAdd BLAST134
Regioni2789 – 2813DisorderedSequence analysisAdd BLAST25
Regioni2893 – 2998DisorderedSequence analysisAdd BLAST106
Regioni3045 – 3174DisorderedSequence analysisAdd BLAST130
Regioni3324 – 3347DisorderedSequence analysisAdd BLAST24
Regioni3391 – 3567DisorderedSequence analysisAdd BLAST177
Regioni3715 – 3738DisorderedSequence analysisAdd BLAST24
Regioni3836 – 3837S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili300 – 320Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 30Polar residuesSequence analysisAdd BLAST23
Compositional biasi111 – 130Polar residuesSequence analysisAdd BLAST20
Compositional biasi131 – 153Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi163 – 178Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi252 – 271Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi372 – 422Polar residuesSequence analysisAdd BLAST51
Compositional biasi462 – 483Polar residuesSequence analysisAdd BLAST22
Compositional biasi484 – 503Pro residuesSequence analysisAdd BLAST20
Compositional biasi640 – 658Polar residuesSequence analysisAdd BLAST19
Compositional biasi674 – 772Polar residuesSequence analysisAdd BLAST99
Compositional biasi773 – 825Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi913 – 930Polar residuesSequence analysisAdd BLAST18
Compositional biasi973 – 988Polar residuesSequence analysisAdd BLAST16
Compositional biasi1176 – 1199Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1205 – 1229Polar residuesSequence analysisAdd BLAST25
Compositional biasi1230 – 1244Pro residuesSequence analysisAdd BLAST15
Compositional biasi1298 – 1319Polar residuesSequence analysisAdd BLAST22
Compositional biasi1752 – 1777Pro residuesSequence analysisAdd BLAST26
Compositional biasi2026 – 2048Polar residuesSequence analysisAdd BLAST23
Compositional biasi2076 – 2104Polar residuesSequence analysisAdd BLAST29
Compositional biasi2119 – 2152Polar residuesSequence analysisAdd BLAST34
Compositional biasi2178 – 2250Polar residuesSequence analysisAdd BLAST73
Compositional biasi2332 – 2348Polar residuesSequence analysisAdd BLAST17
Compositional biasi2349 – 2375Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi2456 – 2524Polar residuesSequence analysisAdd BLAST69
Compositional biasi2651 – 2676Polar residuesSequence analysisAdd BLAST26
Compositional biasi2677 – 2714Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi2715 – 2773Polar residuesSequence analysisAdd BLAST59
Compositional biasi2789 – 2806Polar residuesSequence analysisAdd BLAST18
Compositional biasi2941 – 2998Polar residuesSequence analysisAdd BLAST58
Compositional biasi3045 – 3080Polar residuesSequence analysisAdd BLAST36
Compositional biasi3093 – 3113Polar residuesSequence analysisAdd BLAST21
Compositional biasi3125 – 3152Polar residuesSequence analysisAdd BLAST28
Compositional biasi3160 – 3174Polar residuesSequence analysisAdd BLAST15
Compositional biasi3391 – 3460Polar residuesSequence analysisAdd BLAST70
Compositional biasi3493 – 3536Polar residuesSequence analysisAdd BLAST44
Compositional biasi3545 – 3559Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1074 – 1122CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160099

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDSKMME

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
cd15592, PHD3_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR044133, KMT2A_PHD3
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2R9AMY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XXXXXXAASA ASSSSASSSS SSSSSASSGP ALLRVGPGFD AALQVSAAIG
60 70 80 90 100
TNLRRFRAVF GESGGGGGSG EDEQFLGFGS DEEVRVRSPT RSPSVKTSPR
110 120 130 140 150
KPRGRPRSGS DRNSAILSDP SVFSPLNKSE TKSGDKIKKK DSKSIEKKRG
160 170 180 190 200
RPPTFPGVKI KITHGKDISE LPKGSKEDSL KKIKRTPSAT FQQATKIKKL
210 220 230 240 250
RAGKLSPLKS KFKTGKLQIG RKGVQIVRRR GRPPSTERIK TPSGLLINSE
260 270 280 290 300
LEKPQKVRKD KEGTPPLTKE DKTVVRQSPR RIKPVRIIPS SKRTDATIAK
310 320 330 340 350
QLLQRAKKGA QKKIEKEAAQ LQGRKVKTQV KNIRQFIMPV VSAISSRIIK
360 370 380 390 400
TPRRFIEDED YDPPIKIARL ESTPNSRFSA PSCGSSEKSS AASQHSSQMS
410 420 430 440 450
SDSSRSSSPS VDTSTDSQAS EEIQVLPEER SDTPEVHPPL PISQSPENES
460 470 480 490 500
NDRRSRRYSV SERSFGSRTT KKLSTLQSAP QQQTSSSPPP PLLTPPPPLQ
510 520 530 540 550
PASSISDHTP WLMPPTIPLA SPFLPASTAP MQGKRKSILR EPTFRWTSLK
560 570 580 590 600
HSRSEPQYFS SAKYAKEGLI RKPIFDNFRP PPLTPEDVGF ASGFSASGTA
610 620 630 640 650
ASARLFSPLH SGTRFDMHKR SPLLRAPRFT PSEAHSRIFE SVTLPSNRTS
660 670 680 690 700
AGTSSSGVSN RKRKRKVFSP IRSEPRSPSH SMRTRSGRLS TSELSPLTPP
710 720 730 740 750
SSVSSSLSIS VSPLATSALN PTFTFPSHSL TQSGESAEKN QRPRKQTSAP
760 770 780 790 800
AEPFSSSSPT PLFPWFTPGS QTERGRNKDK APEELSKDRD ADKSVEKDKS
810 820 830 840 850
RERDREREKE NKRESRKEKR KKGSEIQSSS ALYPVGRVSK EKVVGEDVAT
860 870 880 890 900
SSSAKKATGR KKSSSHDSGT DITSVTLGDT TAVKTKILIK KGRGNLEKTN
910 920 930 940 950
LDLGPTAPSL EKEKTLCLST PSSSTVKHST SSIGSMLAQA DKLPMTDKRV
960 970 980 990 1000
ASLLKKAKAQ LCKIEKSKSL KQTDQPKAQG QESDSSETSV RGPRIKHVCR
1010 1020 1030 1040 1050
RAAVALGRKR AVFPDDMPTL SALPWEEREK ILSSMGNDDK SSIAGSEDAE
1060 1070 1080 1090 1100
PLAPPIKPIK PVTRNKAPQE PPVKKGRRSR RCGQCPGCQV PEDCGVCTNC
1110 1120 1130 1140 1150
LDKPKFGGRN IKKQCCKMRK CQNLQWMPSK AYLQKQAKAV KKKEKKSKTS
1160 1170 1180 1190 1200
EKKDSKDSSV VKNVVDSSQK PTPSAREDPA PKKSSSEPPP RKPVEEKSEE
1210 1220 1230 1240 1250
GNVSAPGPES KQATTPASRK SSKQVSQPAL VIPPQPPTTG PPRKEVPKTT
1260 1270 1280 1290 1300
PSEPKKKQPP PPESGPEQSK QKKVAPRPSI PVKQKPKEKE KPPPVNKQEN
1310 1320 1330 1340 1350
AGTLNILSTL SNGNSSKQKI PADGVHRIRV DFKEDCEAEN VWEMGGLGIL
1360 1370 1380 1390 1400
TSVPITPRVV CFLCASSGHV EFVYCQVCCE PFHKFCLEEN ERPLEDQLEN
1410 1420 1430 1440 1450
WCCRRCKFCH VCGRQHQATK QLLECNKCRN SYHPECLGPN YPTKPTKKKK
1460 1470 1480 1490 1500
VWICTKCVRC KSCGSTTPGK GWDAQWSHDF SLCHDCAKLF AKGNFCPLCD
1510 1520 1530 1540 1550
KCYDDDDYES KMMQCGKCDR WVHSKCENLS GTEDEMYEIL SNLPESVAYT
1560 1570 1580 1590 1600
CVNCTERHPA EWRLALEKEL QISLKQVLTA LLNSRTTSHL LRYRQAAKPP
1610 1620 1630 1640 1650
DLNPETEESI PSRSSPEGPD PPVLTEVSKQ DDQQPLDLEG VKRKMDQGNY
1660 1670 1680 1690 1700
TSVLEFSDDI VKIIQAAINS DGGQPEIKKA NSMVKSFFIR QMERVFPWFS
1710 1720 1730 1740 1750
VKKSRFWEPN KVSSNSGMLP NAVLPPSLDH NYAQWQEREE NSHTEQPPLM
1760 1770 1780 1790 1800
KKIIPAPKPK GPGEPDSPTP LHPPTPPILS TDRSREDSPE LNPPPGIEDN
1810 1820 1830 1840 1850
RQCALCLTYG DDSANDAGRL LYIGQNEWTH VNCALWSAEV FEDDDGSLKN
1860 1870 1880 1890 1900
VHMAVIRGKQ LRCEFCQKPG ATVGCCLTSC TSNYHFMCSR AKNCVFLDDK
1910 1920 1930 1940 1950
KVYCQRHRDL IKGEVVPENG FEVFRRVFVD FEGISLRRKF LNGLEPENIH
1960 1970 1980 1990 2000
MMIGSMTIDC LGILNDLSDC EDKLFPIGYQ CSRVYWSTTD ARKRCVYTCK
2010 2020 2030 2040 2050
IVECRPPVVE PDINSTVEHD ENRTIAHSPT SFTESSSKES QNTAEIISPP
2060 2070 2080 2090 2100
SPDRPPHSQT SGSCYYHVIS KVPRIRTPSY SPTQRSPGCR PLPSAGSPTP
2110 2120 2130 2140 2150
TTHEIVTVGD PLLSSGLRSI GSRRHSTSSL SPQRSKLRIM SPMRTGNTYS
2160 2170 2180 2190 2200
RNNVSSVSTI GTATDLESSA KVVDHVLGPL NSSTSLGQNT STSSNLQRTV
2210 2220 2230 2240 2250
VTVGNKNSHL DGSSSSEMKQ SSASDLASKS SSLKGEKTKV LSSKSSEGSA
2260 2270 2280 2290 2300
HNVAYPGIPK LAPQVHNTTS RELNVSKIGS FAEPSSVSFS SKEALSFPHL
2310 2320 2330 2340 2350
HVRGQRNDRD QHTDSTQSAN SSADEDTEVK TLKLSGMSNR SSIINEHMGS
2360 2370 2380 2390 2400
SSRDRRQKGK KSCKETFKEK HSSKSFLEPG QVTTGEEGNL KPEFMDEVLT
2410 2420 2430 2440 2450
PEYMGQRPCN NVSSDKIGDK GLSMPGVPKA PPMQVEGSAK ELQAPRKRTV
2460 2470 2480 2490 2500
KVTLTPLKME NESQSKNALK ESSPASPLQI ESTSPTEPIS ASENPGDGPV
2510 2520 2530 2540 2550
AQPSPNNTSC QDSQSNNYQN LPVQDRNLML PDGPKPQEDG SFKRRYPRRS
2560 2570 2580 2590 2600
ARARSNMFFG LTPLYGVRSY GEEDIPFYSS STGKKRGKRS AEGQVDGADD
2610 2620 2630 2640 2650
LSTSDEDDLY YYNFTRTVIS SGGEERLASH NLFREEEQCD LPKISQLDGV
2660 2670 2680 2690 2700
DDGTESDTSV TATTRKSSQI PKRNGKENGT ENLKIDRPED AGEKEHVTKS
2710 2720 2730 2740 2750
SVGHKNEPKM DNCHSVSRVK TQGQDSLEAQ LSSLESSRRV HTSTPSDKNL
2760 2770 2780 2790 2800
LDTYNTELLK SDSDNNNSDD CGNILPSDIM DFVLKNTPSM QALGESPESS
2810 2820 2830 2840 2850
SSELLNLGEG LGLDSNREKD MGLFEVFSQQ LPTTEPVDSS VSSSISAEEQ
2860 2870 2880 2890 2900
FELPLELPSD LSVLTTRSPT VPSQNPSRLA VISDSGEKRV TITEKSVASS
2910 2920 2930 2940 2950
EGDPALLSPG VDPTPEGHMT PDHFIQGHMD ADHISSPPCG SVEQGHGNNQ
2960 2970 2980 2990 3000
DLTRNSSTPG LQVPVSPTVP IQNQKYVPNS TDSPGPSQIS NAAVQTTPPH
3010 3020 3030 3040 3050
LKPATEKLIV VNQNMQPLYV LQTLPNGVTQ KIQLTSSVSS TPSVMETNTS
3060 3070 3080 3090 3100
VLGPMGGGLT LTTGLNPSLP TSQSLFPSAS KGLLPMSHHQ HLHSFPAATQ
3110 3120 3130 3140 3150
SSFPPNISNP PSGLLIGVQP PPDPQLLVSE SSQRTDLSTT VATPSSGLKK
3160 3170 3180 3190 3200
RPISRLQTRK NKKLAPSSTP SNIAPSDVVS NMTLINFTPS QLPNHPSLLD
3210 3220 3230 3240 3250
LGSLNTSSHR TVPNIIKRSK SSIMYFEPAP LLPQSVGGTA ATAAGTSTIS
3260 3270 3280 3290 3300
QDTSHLTSGS VSGLASSSSV LNVVSMQTTT TPTSSASVPG HVTLTNPRLL
3310 3320 3330 3340 3350
GTPDIGSISN LLIKASQQSL GIQDQPVALP PSSGMFPQLG TSQTPSTAAM
3360 3370 3380 3390 3400
TAASSICVLP STQTTGITAA SPSGEGDEHY QLQHVNQLLA SKTGIHSSQR
3410 3420 3430 3440 3450
DLDSASGPQV SNFTQTVDAP NSMGLEQNKA LSSAVQASPT SPGGSPSSPS
3460 3470 3480 3490 3500
SGQRSASPSV PGPTKPKPKT KRFQLPLDKG NGKKHKVSHL RTSSSEAHIP
3510 3520 3530 3540 3550
DQETTSLTSG TGTPGAEAEQ QDTASVEQSS QKECGQPAGQ VAVLPEVQVT
3560 3570 3580 3590 3600
QNPANEQEST EPKTVEEEES NFSSPLMLWL QQEQKRKESI TEKKPKKGLV
3610 3620 3630 3640 3650
FEISSDDGFQ ICAESIEDAW KSLTDKVQEA RSNARLKQLS FAGVNGLRML
3660 3670 3680 3690 3700
GILHDAVVFL IEQLSGAKHC RNYKFRFHKP EEANEPPLNP HGSARAEVHL
3710 3720 3730 3740 3750
RKSAFDMFNF LASKHRQPPE YNPNDEEEEE VQLKSARRAT SMDLPMPMRF
3760 3770 3780 3790 3800
RHLKKTSKEA VGVYRSPIHG RGLFCKRNID AGEMVIEYAG NVIRSIQTDK
3810 3820 3830 3840 3850
REKYYDSKGI GCYMFRIDDS EVVDATMHGN AARFINHSCE PNCYSRVINI
3860 3870 3880 3890
DGQKHIVIFA MRKIYRGEEL TYDYKFPIED ASNKLPCNCG AKKCRKFLN
Length:3,899
Mass (Da):425,563
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0A3BDEDD085EA64
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R9AI62A0A2R9AI62_PANPA
Histone-lysine N-methyltransferase
3,967Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJFE02068672 Genomic DNA No translation available.
AJFE02068673 Genomic DNA No translation available.
AJFE02068674 Genomic DNA No translation available.
AJFE02068675 Genomic DNA No translation available.
AJFE02068676 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPAT00000039749; ENSPPAP00000017050; ENSPPAG00000031591

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJFE02068672 Genomic DNA No translation available.
AJFE02068673 Genomic DNA No translation available.
AJFE02068674 Genomic DNA No translation available.
AJFE02068675 Genomic DNA No translation available.
AJFE02068676 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

EnsembliENSPPAT00000039749; ENSPPAP00000017050; ENSPPAG00000031591

Phylogenomic databases

GeneTreeiENSGT00940000160099
OMAiYDSKMME

Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
cd15592, PHD3_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR044133, KMT2A_PHD3
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 1 hit
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R9AMY2_PANPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R9AMY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: June 2, 2021
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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