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Entry version 19 (25 May 2022)
Sequence version 1 (20 Jun 2018)
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Protein
Submitted name:

Microtubule actin crosslinking factor 1

Gene

MACF1

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule actin crosslinking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9597 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000240080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 154Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini167 – 271Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini843 – 900SH3InterPro annotationAdd BLAST58
Domaini5055 – 5090EF-handInterPro annotationAdd BLAST36
Domaini5091 – 5126EF-handInterPro annotationAdd BLAST36
Domaini5131 – 5209GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3600 – 3620DisorderedSequence analysisAdd BLAST21
Regioni4965 – 4995DisorderedSequence analysisAdd BLAST31
Regioni5225 – 5408DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili218 – 238Sequence analysisAdd BLAST21
Coiled coili450 – 470Sequence analysisAdd BLAST21
Coiled coili475 – 502Sequence analysisAdd BLAST28
Coiled coili1021 – 1041Sequence analysisAdd BLAST21
Coiled coili1378 – 1408Sequence analysisAdd BLAST31
Coiled coili1472 – 1492Sequence analysisAdd BLAST21
Coiled coili1497 – 1524Sequence analysisAdd BLAST28
Coiled coili1604 – 1638Sequence analysisAdd BLAST35
Coiled coili1768 – 1798Sequence analysisAdd BLAST31
Coiled coili2162 – 2189Sequence analysisAdd BLAST28
Coiled coili2209 – 2229Sequence analysisAdd BLAST21
Coiled coili2267 – 2287Sequence analysisAdd BLAST21
Coiled coili2372 – 2392Sequence analysisAdd BLAST21
Coiled coili2532 – 2552Sequence analysisAdd BLAST21
Coiled coili2591 – 2611Sequence analysisAdd BLAST21
Coiled coili2632 – 2666Sequence analysisAdd BLAST35
Coiled coili2783 – 2803Sequence analysisAdd BLAST21
Coiled coili2904 – 2945Sequence analysisAdd BLAST42
Coiled coili3108 – 3128Sequence analysisAdd BLAST21
Coiled coili3219 – 3239Sequence analysisAdd BLAST21
Coiled coili3872 – 3892Sequence analysisAdd BLAST21
Coiled coili4105 – 4132Sequence analysisAdd BLAST28
Coiled coili4884 – 4904Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3604 – 3619Polar residuesSequence analysisAdd BLAST16
Compositional biasi5244 – 5323Polar residuesSequence analysisAdd BLAST80
Compositional biasi5355 – 5408Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYYQDSC

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 15 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A2R9AMA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SCQAGVQWHD LSSLQPPPPG FKRFSCLSLP SSWDSLSQCL LCVSFTDERD
60 70 80 90 100
RVQKKTFTKW VNKHLMKVRK HINDLYEDLR DGHNLISLLE VLSGIKLPRE
110 120 130 140 150
KGRMRFHRLQ NVQIALDFLK QRQVKLVNIR NDDITDGNPK LTLGLIWTII
160 170 180 190 200
LHFQISDIYI SGESGDMSAK EKLLLWTQKV TAGYTGIKCT NFSSCWSDGK
210 220 230 240 250
MFNALIHRYR PDLVDMERVQ IQSNRENLEQ AFEVAERLGV TRLLDAEDVD
260 270 280 290 300
VPSPDEKSVI TYVSSIYDAF PKVPEGGEGI SATEVDSRWQ EYQSRVDSLI
310 320 330 340 350
PWIKQHTILM SDKTFPQNPV ELKALYNQYI HFKETEILAK EREKGRIEEL
360 370 380 390 400
YKLLEVWIEF GRIKLPQGYH PNDVEEEWGK LIIEMLEREK SLRPAVERLE
410 420 430 440 450
LLLQIANKIQ NGALNCEEKL TLAKNTLQAD AAHLESGQPV QCESDVIMYI
460 470 480 490 500
QECEGLIRQL QVDLQILRDE NYYQLEELAF RVMRLQDELV TLRLECTNLY
510 520 530 540 550
RKGHFTSLEL VPPCTLTTTH LKAEPLTKAT HSSSTSWFRK PMTRAELVAI
560 570 580 590 600
SSSEDEGNLR FVYELLSWVE EMQMKLERAE WGNDLPSVEL QLETQQHIHT
610 620 630 640 650
SVEELGSSVK EARLYEGKMS QNFHTSYAET LGKLETQYCK LKETSSFRMR
660 670 680 690 700
HLQSLHKFVS RATAELIWLN EKEEEELAYD WSDNNSNISA KRNYFSELTM
710 720 730 740 750
ELEEKQDVFR SLQDTAELLS LENHPAKQTV EAYSAAVQSQ LQWMKQLCLC
760 770 780 790 800
VEQHVKENTA YFQFFSDARE LESFLRNLQD SIKRKYSCDH NTSLSRLEDL
810 820 830 840 850
LQDSMVGDEK EQLIQSKSSV ASLVGRSKTI VQLKPRSPDH VLKNTISVKA
860 870 880 890 900
VCDYRQIEIT ICKNDECVLE DNSQRTKWKV ISPTGNEAMV PSVCFLIPPP
910 920 930 940 950
NKDAIEMASR VEQSYQKVMA LWHQLHVNTK SLISWNYLRK DLDLVQTWNL
960 970 980 990 1000
EKLRSSAPGE CHQIMKNLQA HYEDFLQDSR DSVLFSVADR LRLEEEVEAC
1010 1020 1030 1040 1050
KARFQHLMKS MENEDKEETV AKMYISELKN IRLRLEEYEQ RVVKRIQSLA
1060 1070 1080 1090 1100
SSRTDRDARQ DNALRIAEQE HTQEDLQQLR SDLDAVSMKC DSFLHQSPSS
1110 1120 1130 1140 1150
SSVPTLRSEL NLLVEKMDHV YGLSTVYLNK LKTVDVIVRS IQDAELLVKG
1160 1170 1180 1190 1200
YEIKLSQEEV VLADLSALEA HWSTLRHWLS DVKDKNSVFS VLDEEIAKAK
1210 1220 1230 1240 1250
AVAEQMSRLT PERNLDLERY QEKGSQLQER WHRVIAQLEI RQSELESIQE
1260 1270 1280 1290 1300
VLGDYRACHG TLIKWIEETT AQQEMMKPGQ AEDSRVLSEQ LSQQTALFAE
1310 1320 1330 1340 1350
IERNQTKLDQ CQKFSQQYST IVKDYELQLM TYKAFVESQQ KSPGKRRRML
1360 1370 1380 1390 1400
SSSDAITQEF MDLRTRYTAL VTLTTQHVKY ISDALRRLEE EEKVVEEEKQ
1410 1420 1430 1440 1450
EHVEKVKELL GWVSTLARNT QGKATSSETK ESTDIEKAIL EQQVLSEELT
1460 1470 1480 1490 1500
TKKEQVSEAI KTSQIFLAKH GHKLSEKEKK QISEQLNALN KAYHDLCDGS
1510 1520 1530 1540 1550
ANQLQQLQSQ LAHQTEQKTL QKQQNTCHQQ LEDLCSWVGQ AERALAGHQG
1560 1570 1580 1590 1600
RTTQRDLSAL QKNQSDLKDL QDDIQNRATS FATVVKDIEG FMEENQTKLS
1610 1620 1630 1640 1650
PRELTALREK LHQAKEQYEA LQEETRVAQK ELEEAVTSAL QQETEKSKAA
1660 1670 1680 1690 1700
KELAENKKKI DALLDWVTSV GSSGGQLLTN LPGMEQLSGA SLEKGALDTT
1710 1720 1730 1740 1750
DGYMGVNQAP EKLDKQCEMM KARHQELLSQ QQNFILATQS AQAFLDQHGH
1760 1770 1780 1790 1800
NLTPEEQQML QQKLGELKEQ YSTSLAQSEA ELKQVQTLQD ELQKFLQDHR
1810 1820 1830 1840 1850
EFESWLERSE KELENMHKGG SSPEALPSLL KWQGSFSEDV ISHKGDLRFV
1860 1870 1880 1890 1900
TISGQKVLDM ENSFKEGKEP SEIGNLVKDK LKDATERYTA LHSKCTRLGS
1910 1920 1930 1940 1950
HLNMLLGQYH QFQNSADSLQ AWMQACEANV EKLLSDTVAS DPGVLQEQLA
1960 1970 1980 1990 2000
TTKQLQEELA EHQVPVEKLQ KVARDIMEIE GEPAPDHRHV QETTDSILSH
2010 2020 2030 2040 2050
FQSLSYSLAE RSSLLQKAIA QSQSVQESLE SLLQSIGEVE QNLEGKQVSS
2060 2070 2080 2090 2100
LSSGVIQEAL ATNMKLKQDI ARQKSSLEAT REMVTRFMET ADSTTAAVLQ
2110 2120 2130 2140 2150
GKLAEVSQRF EQLCLQQQEK ESSLKKLLPQ AEMFEHLSGK LQQFMENKSR
2160 2170 2180 2190 2200
MLASGNQPDQ DITHFFQQIQ ELNLEMEDQQ ENLDTLEHLV TELSSCGFAL
2210 2220 2230 2240 2250
DLCQHQDRVQ NLRKDFTELQ KTVKEREKDA SSCQEQLDEF RKLVRTFQKW
2260 2270 2280 2290 2300
LKETEGSIPP TETSMSAKEL EKQIEHLKSL LDDWASKGTL VEEINCKGTS
2310 2320 2330 2340 2350
LENLIMEITA PDSQGKTGSI LPSVGSSVGS VNGYHTCKDL TEIQCDMSDV
2360 2370 2380 2390 2400
NLKYEKLGGV LHERQESLQA ILNRMEEVHK EANSVLQWLE SKEEVLKSMD
2410 2420 2430 2440 2450
AMSSPTKTET VKAQAESNKA FLAELEQNSP KIQKVKEALA GLLVTYPNSQ
2460 2470 2480 2490 2500
EAENWKKIQE ELNSRWERAT EVTVARQRQL EESASHLACF QAAESQLRPW
2510 2520 2530 2540 2550
LMEKELMMGV LGPLSIDPNM LNAQKQQVQF MLKEFEARRQ QHEQLNEAAQ
2560 2570 2580 2590 2600
GILTGPGDVS LSTSQVQKEL QSINQKWVEL TDKLNSRSSQ IDQAIVKSTQ
2610 2620 2630 2640 2650
YQELLQDLSE KVRAVGQRLS VQSAISTQPE AVKQQLEETS EIRSDLEQLD
2660 2670 2680 2690 2700
HEVKEAQTLC DELSVLIGEQ YLKDELKKRL ETVALPLQGL EDLAADRMNR
2710 2720 2730 2740 2750
LQAALASTQQ FQQMFDELRT WLDDKQSQQA KNCPISAKLE RLQSQLQENE
2760 2770 2780 2790 2800
EFQKSLNQHS GSYEVIVAEG ESLLLSVPPG EEKRTLQNQL VELKNHWEEL
2810 2820 2830 2840 2850
SKKTADRQSR LKDCMQKAQK YQWHVEDLVP WIEDCKAKMS ELRVTLDPVQ
2860 2870 2880 2890 2900
LESSLLRSKA MLSEVEKRRS LLEILNSAAD ILINSSEADE DGIRDEKAGI
2910 2920 2930 2940 2950
NQNMDAVTEE LQAKTGSLEE MTQRLKEFQE SFKNIEKKVE GAKHQLEIFD
2960 2970 2980 2990 3000
ALGSQACSNK NLEKLRAQQE VLQALEPQVD YLRNFTQGLV EDAPDGSDAS
3010 3020 3030 3040 3050
QLLHQAEVAQ QEFLEVKQRV NSGCVMMENK LEGIGQFHCR VREMFSQLAD
3060 3070 3080 3090 3100
LDDELDGMGA IGRDTDSLQS QIEDVRLFLN KIHILKLDIE ASEAECRHML
3110 3120 3130 3140 3150
EEEGTLDLLG LKRELEALNK QCGKLTERGK ARQEQLELTL GRVEDFYRKL
3160 3170 3180 3190 3200
KGLNDATTAA EEAEALQWVV GTEVEIINQQ LADFKMFQKE QVDPLQMKLQ
3210 3220 3230 3240 3250
QVNGLGQGLI QSAGKDCDVQ GLEHDMEEIN ARWNTLNKKV AQRIAQLQEA
3260 3270 3280 3290 3300
LLHCGKFQDA LEPLLSWLAD TEELIANQKP PSAEYKVVKA QIQEQKLLQR
3310 3320 3330 3340 3350
LLDDRKATVD MLQAEGGRIA QSAELADREK ITGQLESLES RWTELLSKAA
3360 3370 3380 3390 3400
ARQKQLEDIL VLAKQFHETA EPISDFLSVT EKKLANSEPV GTQTAKIQQQ
3410 3420 3430 3440 3450
IIRHKALEED IENHATDVHQ AVKIGQSLSS LTSPAEQGVL SEKIDSLQAR
3460 3470 3480 3490 3500
YSEIQDRCCR KAALLDQALS NARLFGEDEV EVLNWLAEVE DKLSSVFIKD
3510 3520 3530 3540 3550
FKQDVLHRQH ADHLALNEEI VNRKKNVDQA IKNGQALLKQ TTGEEVLLIQ
3560 3570 3580 3590 3600
EKLDGIKTRY ADITVTSSKA LRTLEQARQL ATKFQSTYEE LTGWLREVEE
3610 3620 3630 3640 3650
ELATSGGQSP TGEQIPQFQQ RQKELKKEVM EHRLVLDTVN EVSRALLELV
3660 3670 3680 3690 3700
PWRAREGLDK LVSDANEQYK LVSDTIGQRV DEIDAAIQRS QQYEQAADAE
3710 3720 3730 3740 3750
LAWVAETKRK LMALGPIRLE QDQTTAQLQV QKAFSIDIIR HKDSMDELFS
3760 3770 3780 3790 3800
HRSEIFGTCG EEQKTVLQEK TESLIQEYEA ISLLNSERYA RLERAQVLVN
3810 3820 3830 3840 3850
QFWETYEELS PWIEETRALI AQLPPPAIDH EQLRQQQEEM RQLRESIAEH
3860 3870 3880 3890 3900
KPHIDKLLKI GPQLKELNPE EGEMVEEKYQ KAENMYAQIK EEVRQRALAL
3910 3920 3930 3940 3950
DEAVSQSTQF HDKIEPMLET LENLSSRLRM PPLIPAEVDK IRECISDNKS
3960 3970 3980 3990 4000
ATVELEKLQP SFEALKRRGE ELIGRSQGAD KDLAAKEIQD KLDQMVFFWE
4010 4020 4030 4040 4050
DIKARAEERE IKFLDVLELA EKFWYDMAAL LTTIKDTQDI VHDLESPGID
4060 4070 4080 4090 4100
PSIIKQQVEA AETIKEETDG LHEELEFIRI LGADLIFACG ETEKPEVRKS
4110 4120 4130 4140 4150
IDEMNNAWEN LNKTWKERLE KLEDAMQAAV QYQDTLQAMF DWLDNTVIKL
4160 4170 4180 4190 4200
CTMPPVGTDL NTVKDQLNEM KEFKVEVYQQ QIEMEKLNHQ GELMLKKATD
4210 4220 4230 4240 4250
ETDRDIIREP LTELKHLWEN LGEKIAHRQH KLEGALLALG QFQHALEELM
4260 4270 4280 4290 4300
SWLTHTEELL DAQRPISGDP KVIEVELAKH HVLKNDVLAH QATVETVNKA
4310 4320 4330 4340 4350
GNELLESSAG DDASSLRSRL ETMNQCWESV LQKTEEREQQ LQSTLQQAQG
4360 4370 4380 4390 4400
FHSEIEDFLL ELTRMESQLS ASKPTGGLPE TAREQLDTHM ELYSQLKAKE
4410 4420 4430 4440 4450
ETYNQLLDKG RLMLLSRDDS GSGSKTEQSV ALLEQKWHVV SSKMEERKSK
4460 4470 4480 4490 4500
LEEALNLATE FQNSLQEFIN WLTLAEQSLN IASPPSLILN TVLSQIEEHK
4510 4520 4530 4540 4550
VFANEVNAHR DQIIELDQTG NQLKFLSQKQ DVVLIKNLLV SVQSRWEKVV
4560 4570 4580 4590 4600
QRSIERGRSL DDARKRAKQF HEAWKKLIDW LEDAESHLDS ELEISNDPDK
4610 4620 4630 4640 4650
IKLQLSKHKE FQKTLGGKQP VYDTTIRTGR ALKEKTLLPE DTQKLDNFLG
4660 4670 4680 4690 4700
EVRDKWDTVC GKSVERQHKL EEALLFSGQF MDALQALVDW LYKVEPQLAE
4710 4720 4730 4740 4750
DQPVHGDLDL VMNLMDAHKV FQKELGKRTG TVQVLKRSGR ELIENSRDDT
4760 4770 4780 4790 4800
TWVKGQLQEL STRWDTVCKL SVSKQSRLEQ ALKQAEVFRD TVHMLLEWLS
4810 4820 4830 4840 4850
EAEQTLRFRG ALPDDTEALQ SLIDTHKEFM KKVEEKRVDV NSAVAMGEVI
4860 4870 4880 4890 4900
LAVCHPDCIT TIKHWITIIR ARFEEVLTWA KQHQQRLETA LSELVANAEL
4910 4920 4930 4940 4950
LEELLAWIQW AETTLIQRDQ EPIPQNIDRV KALIAEHQTF MEEMTRKQPD
4960 4970 4980 4990 5000
VDRVTKTYKR KNIEPTHAPF IEKSRSGGRK SLSQPTPPPM PILSQSEAKN
5010 5020 5030 5040 5050
PRINQLSARW QQVWLLALER QRKLNDALDR LEELKEFANF DFDVWRKKYM
5060 5070 5080 5090 5100
RWMNHKKSRV MDFFRRIDKD QDGKITRQEF IDGILASKFP TTKLEMTAVA
5110 5120 5130 5140 5150
DIFDRDGDGY IDYYEFVAAL HPNKDAYRPT TDADKIEDEV TRQVAQCKCA
5160 5170 5180 5190 5200
KRFQVEQIGE NKYRFPLILQ FGDSQQLRLV RILRSTVMVR VGGGWMALDE
5210 5220 5230 5240 5250
FLVKNDPCRA RGRTNIELRE KFILPEGASQ GMTPFRSRGR RSKPSSRAAS
5260 5270 5280 5290 5300
PTRSSSSASQ SNHSCTSMPS SPATPASGTK VIPSSGSKLK RPTPTFHSSR
5310 5320 5330 5340 5350
TSLAGDTSNS SSPASTGAKT NRADPKKSAS RPGSRAGSRA GSRASSRRGS
5360 5370 5380 5390 5400
DASDFDLLET QSACSDTSES SAAGGQGNSR RGLNKPSKIP TMSKKTTTAS

PRTPGPKR
Length:5,408
Mass (Da):617,796
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE68AB8F2CEBBD9B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R9AM41A0A2R9AM41_PANPA
Microtubule actin crosslinking fact...
MACF1
7,557Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R9ART1A0A2R9ART1_PANPA
Microtubule actin crosslinking fact...
MACF1
7,360Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R9ARW4A0A2R9ARW4_PANPA
Microtubule actin crosslinking fact...
MACF1
7,316Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R9AU70A0A2R9AU70_PANPA
Microtubule actin crosslinking fact...
MACF1
7,567Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R9AMF3A0A2R9AMF3_PANPA
Microtubule actin crosslinking fact...
MACF1
1,055Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R9AMI0A0A2R9AMI0_PANPA
Microtubule actin crosslinking fact...
MACF1
616Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJFE02051263 Genomic DNA No translation available.
AJFE02051264 Genomic DNA No translation available.
AJFE02051265 Genomic DNA No translation available.
AJFE02051266 Genomic DNA No translation available.
AJFE02051267 Genomic DNA No translation available.
AJFE02051268 Genomic DNA No translation available.
AJFE02051269 Genomic DNA No translation available.
AJFE02051270 Genomic DNA No translation available.
AJFE02051271 Genomic DNA No translation available.
AJFE02051272 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPAT00000041224; ENSPPAP00000018492; ENSPPAG00000032133

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJFE02051263 Genomic DNA No translation available.
AJFE02051264 Genomic DNA No translation available.
AJFE02051265 Genomic DNA No translation available.
AJFE02051266 Genomic DNA No translation available.
AJFE02051267 Genomic DNA No translation available.
AJFE02051268 Genomic DNA No translation available.
AJFE02051269 Genomic DNA No translation available.
AJFE02051270 Genomic DNA No translation available.
AJFE02051271 Genomic DNA No translation available.
AJFE02051272 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSPPAT00000041224; ENSPPAP00000018492; ENSPPAG00000032133

Phylogenomic databases

GeneTreeiENSGT00940000155824
OMAiNYYQDSC

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 15 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 17 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R9AMA8_PANPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R9AMA8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: May 25, 2022
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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