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Entry version 12 (12 Aug 2020)
Sequence version 1 (20 Jun 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

TNRC6A

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9597 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000240080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1078 – 1204Ago_hookInterPro annotationAdd BLAST127
Domaini1283 – 1484M_domainInterPro annotationAdd BLAST202
Domaini1508 – 1781TNRC6-PABC_bdgInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 155DisorderedSequence analysisAdd BLAST155
Regioni175 – 296DisorderedSequence analysisAdd BLAST122
Regioni438 – 457DisorderedSequence analysisAdd BLAST20
Regioni497 – 519DisorderedSequence analysisAdd BLAST23
Regioni563 – 702DisorderedSequence analysisAdd BLAST140
Regioni721 – 1144DisorderedSequence analysisAdd BLAST424
Regioni1157 – 1199DisorderedSequence analysisAdd BLAST43
Regioni1252 – 1275DisorderedSequence analysisAdd BLAST24
Regioni1326 – 1373DisorderedSequence analysisAdd BLAST48
Regioni1427 – 1459DisorderedSequence analysisAdd BLAST33
Regioni1580 – 1638DisorderedSequence analysisAdd BLAST59
Regioni1727 – 1752DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 52PolyampholyteSequence analysisAdd BLAST52
Compositional biasi56 – 131PolarSequence analysisAdd BLAST76
Compositional biasi175 – 233PolarSequence analysisAdd BLAST59
Compositional biasi258 – 296PolarSequence analysisAdd BLAST39
Compositional biasi563 – 679PolarSequence analysisAdd BLAST117
Compositional biasi680 – 702PolyampholyteSequence analysisAdd BLAST23
Compositional biasi721 – 740PolarSequence analysisAdd BLAST20
Compositional biasi752 – 785PolarSequence analysisAdd BLAST34
Compositional biasi804 – 821PolarSequence analysisAdd BLAST18
Compositional biasi835 – 953PolarSequence analysisAdd BLAST119
Compositional biasi985 – 1007PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1014 – 1060PolarSequence analysisAdd BLAST47
Compositional biasi1097 – 1122PolarSequence analysisAdd BLAST26
Compositional biasi1157 – 1175PolarSequence analysisAdd BLAST19
Compositional biasi1326 – 1368PolarSequence analysisAdd BLAST43
Compositional biasi1729 – 1743Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12711, RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2R9A4V8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ELEAKATKDV ERNLSRDLVQ EEEQLMEEKK KKKDDKKKKE AAQKKATEQK
60 70 80 90 100
IKVPEQIKPS VSQPQPANSN NGTSTATSTN NNAKRATANN QQPQQQQQQQ
110 120 130 140 150
QQQQQQPQQQ PQPQPQQQQQ QQQQPQQQPQ ALPRYPREVP PRFRHQEHKQ
160 170 180 190 200
LLKRGQHFPV IAANLGSAVK VLNSQSESSA LTNQQPQNNG EVQNSKNQSD
210 220 230 240 250
INHSTSGSHY ENSQRGPVSS TSDSSTNCKN AVVSDLSEKE AWPSAPGSDP
260 270 280 290 300
ELASECMDAD SASSSESERN ITIMASGNTG GEKDGLRNST GLGSQNKFVV
310 320 330 340 350
GSSSNNVGHG SSTGPWGFSH GAIISTCQVS VDAPESKSES SNNRMNAWGT
360 370 380 390 400
VSSSSNGGLN PSTLNSASNH GAWPVLENNG LALKGPVGSG SSGINIQCST
410 420 430 440 450
IGQMPNNQSI NSKVSGGSTH GTWGSLQETC ESEVSGTQKV SFSGQPQNIT
460 470 480 490 500
TEMTGPNNTT NFMTSSLPNS GSVQNNELPS SNTGAWRVST MNHPQMQAPS
510 520 530 540 550
GMNGTSLSHL SNGESKSGGS YGTTWGAYGS NYSGDKCSGP NGQANGDTVN
560 570 580 590 600
ATLMQPGVNG PMGTNFQVNT NKGGGVWESG AANSQSTSWG SGNGANSGGS
610 620 630 640 650
RRGWGTPAQN TGTNLPSVEW NKLPSNQHSN DSANGNGKTF TNGWKSTEEE
660 670 680 690 700
DQGSATSQTN EQSSVWAKTG GTVESDGSTE STGRLEEKGT GESQSRDRRK
710 720 730 740 750
IDQHTLLQSI VNRTDLDPRV LSNSGWGQTP IKQNTAWDTE TSPRGERKTD
760 770 780 790 800
NGTEAWGSSA TQTFNSGACI DKTSPNGNDT SSVSGWGDPK PALRWGDSKG
810 820 830 840 850
SNCQGGWEDD SAATGMVKSN QWGNCKEEKA AWNDSQKNKQ GWGDGQKSSQ
860 870 880 890 900
GWSVSASDNW GETSRSNHWG EANKKSSSGG SDSDRSVSGW NELGKTSSFT
910 920 930 940 950
WGNNINPNNS SGWDESSKPT PSQGWGDPPK SNQSLGWGDS SKPVSSPDWN
960 970 980 990 1000
KQQDIVGSWG IPPATGKPPG TGWLGGPIPA PAKEEEPTGW EEPSPESIRR
1010 1020 1030 1040 1050
KMEIDDGTSA WGDPSKYNYK NVNMWNKNVP NGNSRSDQQA QVHQLLTPAS
1060 1070 1080 1090 1100
AISNKEASSG SGWGEPWGEP STPATTVDNG TSAWGKPIDS GPSWGEPIAA
1110 1120 1130 1140 1150
ASSTSTWGSS SVGPQALSKS GPKSMQDGWC GDDMPLPGNR PTGWEEEEDV
1160 1170 1180 1190 1200
EIGMWNSNSS QELNSSLNWP PYSKKMSSKG LSGKKRRRER GMMKGGNKQE
1210 1220 1230 1240 1250
EAWINPFVKQ FSNISFSRDS PEENVQSNKM DLSGGMLQDK RMEIDKHSLN
1260 1270 1280 1290 1300
IGDYNRTVGK GPGSRPQISK ESSMERNPYF DKDGIVADES QNMQFMSSQS
1310 1320 1330 1340 1350
MKLPPSNSAL PNQALGSIAG LGMQNLNSVR QNGNPSMFGV GNTAAQPRGM
1360 1370 1380 1390 1400
QQPPAQPLSS SQPNLRAQVP PPLLSPQVPV SLLKYAPNNG GLNPLFGPQQ
1410 1420 1430 1440 1450
VAMLNQLSQL NQLSQISQLQ RLLAQQQRAQ SQRSVPSGNR PQQDQQGRPL
1460 1470 1480 1490 1500
SVQQQMMQQS RQLDPNLLVK QQTPPSQQQP LHQPAMKSFL DNVMPHTTPE
1510 1520 1530 1540 1550
LQKGPSPINA FSNFPIGLNS NLNVNMDMNS IKEPQSRLRK WTTVDSISVN
1560 1570 1580 1590 1600
TSLDQNSSKH GAISSGFRLE ESPFVPYDFM NSSTSPASPP GSIGDGWPRA
1610 1620 1630 1640 1650
KSPNGSSSVN WPPEFRPGEP WKGYPNIDPE TDPYVTPGSV INNLSINTVR
1660 1670 1680 1690 1700
EVDHLRDRNS GSSSSLNTTL PSTSAWSSIR ASNYNVPLSS TAQSTSARNS
1710 1720 1730 1740 1750
DSKLTWSPGS VTNTSLAHEL WKVPLPPKNI TAPSRPPPGL TGQKPPLSTW
1760 1770 1780 1790 1800
DNSPLRIGGG WGNSDARYTP GSSWGESSSG RITNWLVLKN LTPQIDGSTL
1810 1820 1830 1840 1850
RTLCMQHGPL ITFHLNLPHG NALVRYSSKE EVVKAQKSLH MCVLGNTTIL
1860 1870 1880 1890 1900
AEFASEEEIS RFFAQSQSLT PSPSWQSLGS SQSRLGSLDC SHSFSSRTDL
1910 1920 1930 1940 1950
NHWNGAGLSG TNCGDLHGTS LWGTPHYSTS LWGPPSSSDP RGISSPSPIN
1960
AFLSVDHLGG GGESM
Length:1,965
Mass (Da):210,670
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6F063D94DFCFD1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R9A4V3A0A2R9A4V3_PANPA
Uncharacterized protein
TNRC6A
1,916Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8ZZB5A0A2R8ZZB5_PANPA
Uncharacterized protein
TNRC6A
1,936Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJFE02043590 Genomic DNA No translation available.
AJFE02043591 Genomic DNA No translation available.
AJFE02043592 Genomic DNA No translation available.
AJFE02043593 Genomic DNA No translation available.
AJFE02043594 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPAT00000032970; ENSPPAP00000010320; ENSPPAG00000028379

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJFE02043590 Genomic DNA No translation available.
AJFE02043591 Genomic DNA No translation available.
AJFE02043592 Genomic DNA No translation available.
AJFE02043593 Genomic DNA No translation available.
AJFE02043594 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSPPAT00000032970; ENSPPAP00000010320; ENSPPAG00000028379

Phylogenomic databases

GeneTreeiENSGT00940000158180

Family and domain databases

CDDicd12711, RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R9A4V8_PANPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R9A4V8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: August 12, 2020
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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