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Entry version 12 (02 Jun 2021)
Sequence version 1 (20 Jun 2018)
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Protein
Submitted name:

Cilia and flagella associated protein 74

Gene

CFAP74

Organism
Pan paniscus (Pygmy chimpanzee) (Bonobo)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cilia and flagella associated protein 74Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP74Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan paniscus (Pygmy chimpanzee) (Bonobo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9597 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000240080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni41 – 60DisorderedSequence analysisAdd BLAST20
Regioni370 – 390DisorderedSequence analysisAdd BLAST21
Regioni693 – 740DisorderedSequence analysisAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili302 – 322Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi705 – 728Basic and acidic residuesSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141054

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPTVAPS

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2R8ZE09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDDGSLLPE DQLLADALPL EDERDELEDP EFDIKCLLQE AEDDVDPGHS
60 70 80 90 100
SSVKELDTDA DKLKKKTAED RMQAFHLRQN LSALDKMHEE QELFIEKMRG
110 120 130 140 150
ELRACRQRRD LIHKQQEAVA AEIATEEEAG NMATVGRLQA VSRRLFAELE
160 170 180 190 200
NERDLQSRTE AVLKESENTM WHIEIQEGRL EAFRTADREE VEATGRRLQV
210 220 230 240 250
RAAEQLCREQ EALGKVERNR LLRIRKSLHT QKELGLRHQK LLEDARKNHK
260 270 280 290 300
VAVWFLKASL GRIREQEKKE EMECHEYMRR RMDAVVALKG SISANRDTLR
310 320 330 340 350
KFQAWDRAKA ELAEQRVQAE KKAILAQGRD AFRHLVHQRR HQELEAQKRA
360 370 380 390 400
FEEEQKLRKQ EIVSRILKEE AEEEKRKKQH PPTSARHRPT LRDKTWNYIS
410 420 430 440 450
DFCKEKTTVP TNTSTLDYEA AAGPGPSRLL QVVSSELIQG DPGASSEEET
460 470 480 490 500
LAEPEISGLW NEDYKPYQVP KEDVDRKPVG GTKMDKDILE RTVERLRSRV
510 520 530 540 550
VHKQVVWGRE FQGRPFNSKP ELLHFQDFDI GKVYKKKITL VNTTYTINYC
560 570 580 590 600
KLVGVEGHLR DFIHVDFDPP GPLSAGMSCE VLVTFKPMIN KDLEGNISFL
610 620 630 640 650
AQTGEFSVPL KCSTKKCSLS LDKELIDFGS YVVGETTSRT ITLTNVGGLG
660 670 680 690 700
TTFKFLPASE PCEMDDSQSA LKLSSLLTYE DKSLYDKAAT SFSEQQLEGT
710 720 730 740 750
ESSQADMQSR KELEKLDKEQ EEEQPAEPER LTTVIPPSEE QTEITLGEVT
760 770 780 790 800
EGEIGPFSSI KVPIIFTPVV PGDVQARFKV TFKNPQCPTL HFRVVGVAID
810 820 830 840 850
VPVWVPKPSV DLKICMYDRL YQDSVLVHTR SKAALRLKFE VCKELRAHLE
860 870 880 890 900
LLPETGYIQA QSSYSVQLKF LPRHSLPEDA GRYFDKETRV LEAPMTIWVA
910 920 930 940 950
DQNKPVGFTV HAIVTTSDLE LSPSEVDFGY CTIYEAIRTE ISLHNHSLLP
960 970 980 990 1000
QEFGFVRLPK FVDVQPNDGF GTILPLETLQ FCVIFQPTEA KEHRFQLTCK
1010 1020 1030 1040 1050
SEINRCFKLS CRAVGVHPPL ELSHYQIKFA ATALYDTSVA TVYVINSHLS
1060 1070 1080 1090 1100
MSSRNHSKPR IGSEDASPMG PTSFEFLLPP DSPITISPSV GTVWPGKRCL
1110 1120 1130 1140 1150
VQVAFRPVLP EKLIRQEALP LLNKEMETKS FRKDMAPQRK DRHRLSFSVL
1160 1170 1180 1190 1200
RAQNRDKLFK VSVPHVLEMR KRELKPSSDE YQAARATLLR AFQAKFDTFV
1210 1220 1230 1240 1250
VPCVVASGDI KDRKGSEPLS FSPHNTLYLE LWCPTVAPSV VVTSHKGKTI
1260 1270 1280 1290 1300
FNFGDVAVGH RSIKKISIQN VSPEDLALDF SLLNPNGPFV LLNHSSLLRA
1310 1320 1330 1340 1350
GGTQVLVLSF SPHESILAQE TLDIITKRGT LTLTLLGTGV ASMITCSIEG
1360 1370 1380 1390 1400
SVLNMGYVIA GESVSSGFKL QNNSLLPIKF SMHLDSLSST RGRGQQQLPQ
1410 1420 1430 1440 1450
FLSSPSQRTE VVGTQNLNGQ SVFGVAPIKG VMDPGKAQDF TVTFSPDHES
1460 1470 1480 1490 1500
LYFSDRLQVV LFDKKISHQI LLKGAACQHM MFVEGGDPLD VPVESLTAIP
1510 1520 1530 1540 1550
VFDPRHREEA EELRPILVTL DYIQFDTDTP APPATRELQV GCIRTTQPSP
1560 1570 1580
KKPDHPLMVS ALLQLRGDVK ETYKVIFVAQ VLTGP
Length:1,585
Mass (Da):178,730
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0470B3F0CA32C7F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJFE02021166 Genomic DNA No translation available.
AJFE02021167 Genomic DNA No translation available.
AJFE02021168 Genomic DNA No translation available.
AJFE02021169 Genomic DNA No translation available.
AJFE02021170 Genomic DNA No translation available.
AJFE02021171 Genomic DNA No translation available.
AJFE02021172 Genomic DNA No translation available.
AJFE02021173 Genomic DNA No translation available.
AJFE02021174 Genomic DNA No translation available.
AJFE02021175 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPAT00000009040; ENSPPAP00000001818; ENSPPAG00000008102

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJFE02021166 Genomic DNA No translation available.
AJFE02021167 Genomic DNA No translation available.
AJFE02021168 Genomic DNA No translation available.
AJFE02021169 Genomic DNA No translation available.
AJFE02021170 Genomic DNA No translation available.
AJFE02021171 Genomic DNA No translation available.
AJFE02021172 Genomic DNA No translation available.
AJFE02021173 Genomic DNA No translation available.
AJFE02021174 Genomic DNA No translation available.
AJFE02021175 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSPPAT00000009040; ENSPPAP00000001818; ENSPPAG00000008102

Phylogenomic databases

GeneTreeiENSGT00900000141054
OMAiCPTVAPS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R8ZE09_PANPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R8ZE09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: June 2, 2021
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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