UniProtKB - A0A2R8YGN5 (A0A2R8YGN5_HUMAN)
Protein
V-type proton ATPase subunit a
Gene
ATP6V0A4
Organism
Homo sapiens (Human)
Status
Functioni
Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation
GO - Molecular functioni
- proton transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Hydrogen ion transportUniRule annotation, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase subunit aUniRule annotation |
Gene namesi | Name:ATP6V0A4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:866, ATP6V0A4 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
- proton-transporting V-type ATPase, V0 domain Source: InterPro
Keywords - Cellular componenti
MembraneFamily & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 93 – 127 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000182881 |
Family and domain databases
InterProi | View protein in InterPro IPR002490, V-ATPase_116kDa_su |
PANTHERi | PTHR11629, PTHR11629, 1 hit |
Pfami | View protein in Pfam PF01496, V_ATPase_I, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8YGN5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NMNVNSFQRK
60 70 80 90 100
FVNEVRRCES LERILRFLED EMQNEIVVQL LEKSPLTPLP REMITLETVL
110 120 130 140 150
EKLEGELQEA NQNQQALKQS FLELTELKYL LKKTQDFFET ETNLADDFFT
160 170
EDTSGLLELK AVPAYMTGKL G
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9HBG4 | VPP4_HUMAN | V-type proton ATPase 116 kDa subuni... | ATP6V0A4 ATP6N1B, ATP6N2 | 840 | Annotation score: | ||
A0A2R8Y6X9 | A0A2R8Y6X9_HUMAN | V-type proton ATPase subunit a | ATP6V0A4 | 582 | Annotation score: | ||
A0A2R8YE46 | A0A2R8YE46_HUMAN | V-type proton ATPase subunit a | ATP6V0A4 | 456 | Annotation score: | ||
A0A2R8Y7G6 | A0A2R8Y7G6_HUMAN | V-type proton ATPase subunit a | ATP6V0A4 | 353 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 171 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018663 Genomic DNA No translation available. AC020983 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000483139; ENSP00000496205; ENSG00000105929 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018663 Genomic DNA No translation available. AC020983 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A2R8YGN5 |
Protocols and materials databases
Antibodypediai | 3120, 120 antibodies |
Genome annotation databases
Ensembli | ENST00000483139; ENSP00000496205; ENSG00000105929 |
Organism-specific databases
HGNCi | HGNC:866, ATP6V0A4 |
OpenTargetsi | ENSG00000105929 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182881 |
Miscellaneous databases
ChiTaRSi | ATP6V0A4, human |
Gene expression databases
ExpressionAtlasi | A0A2R8YGN5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002490, V-ATPase_116kDa_su |
PANTHERi | PTHR11629, PTHR11629, 1 hit |
Pfami | View protein in Pfam PF01496, V_ATPase_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8YGN5_HUMAN | |
Accessioni | A0A2R8YGN5Primary (citable) accession number: A0A2R8YGN5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | February 10, 2021 | |
This is version 15 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |