UniProtKB - A0A2R8YGD1 (A0A2R8YGD1_HUMAN)
Protein
Tripeptidyl aminopeptidase
Gene
TPP1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.ARBA annotation EC:3.4.14.9
Cofactori
Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per subunit.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 179 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 183 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 382 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Metal bindingi | 424 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 425 | Calcium; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 448 | Calcium; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 450 | CalciumPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-UniRule
- serine-type endopeptidase activity Source: UniProtKB-UniRule
- tripeptidyl-peptidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase, Protease, Serine proteasePROSITE-ProRule annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Tripeptidyl aminopeptidaseARBA annotation (EC:3.4.14.9ARBA annotation)Alternative name(s): Tripeptidyl-peptidase 1ARBA annotation Tripeptidyl-peptidase IARBA annotation |
Gene namesi | Name:TPP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2073, TPP1 |
Subcellular locationi
Lysosome
- lysosome Source: UniProtKB-KW
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015333583 | 22 – 470 | Tripeptidyl aminopeptidaseSequence analysisAdd BLAST | 449 |
Proteomic databases
PeptideAtlasi | A0A2R8YGD1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 106 – 470 | Peptidase S53InterPro annotationAdd BLAST | 365 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00390000008684 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF00082, Peptidase_S8, 1 hit PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8YGD1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT
60 70 80 90 100
FALRQQNVER LSELVQAVSD PSSPQYVGGL HRFPPTSSLR QRPEPQVTGT
110 120 130 140 150
VGLHLGVTPS VIRKRYNLTS QDVGSGTSNN SQACAQFLEQ YFHDSDLAQF
160 170 180 190 200
MRLFGGNFAH QASVARVVGQ QGRGRAGIEA SLDVQYLMSA GANISTWVYS
210 220 230 240 250
SPGRHEGQEP FLQWLMLLSN ESALPHVHTV SYGDDEDSLS SAYIQRVNTE
260 270 280 290 300
LMKAAARGLT LLFASGDSGA GCWSVSGRHQ FRPTFPASSP YVTTVGGTSF
310 320 330 340 350
QEPFLITNEI VDYISGGGFS NVFPRPSYQE EAVTKFLSSS PHLPPSSYFN
360 370 380 390 400
ASGRAYPDVA ALSDGYWVVS NRVPIPWVSG TSASTPVFGG ILSLINEHRI
410 420 430 440 450
LSGRPPLGFL NPRLYQQHGA GLFDVTRGCH ESCLDEEVEG QGFCSGPGWD
460 470
PVTGWGTPNF PALLKTLLNP
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14773 | TPP1_HUMAN | Tripeptidyl-peptidase 1 | TPP1 CLN2, GIG1, UNQ267/PRO304 | 563 | Annotation score: | ||
A0A2R8Y7U1 | A0A2R8Y7U1_HUMAN | Tripeptidyl aminopeptidase | TPP1 | 400 | Annotation score: | ||
A0A2R8YD45 | A0A2R8YD45_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 500 | Annotation score: | ||
A0A2R8YE64 | A0A2R8YE64_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 162 | Annotation score: | ||
A0A2R8YCK4 | A0A2R8YCK4_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 81 | Annotation score: | ||
A0A2R8Y7I4 | A0A2R8Y7I4_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 162 | Annotation score: | ||
E9PME9 | E9PME9_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 30 | Annotation score: | ||
E9PPA4 | E9PPA4_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 39 | Annotation score: | ||
E7EV34 | E7EV34_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 170 | Annotation score: | ||
A0A2R8YD72 | A0A2R8YD72_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 92 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091564 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000644810; ENSP00000495895; ENSG00000166340 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091564 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A2R8YGD1 |
Protocols and materials databases
Antibodypediai | 23932, 410 antibodies |
Genome annotation databases
Ensembli | ENST00000644810; ENSP00000495895; ENSG00000166340 |
Organism-specific databases
HGNCi | HGNC:2073, TPP1 |
OpenTargetsi | ENSG00000166340 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000008684 |
Miscellaneous databases
ChiTaRSi | TPP1, human |
Gene expression databases
ExpressionAtlasi | A0A2R8YGD1, baseline and differential |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit |
Gene3Di | 3.40.50.200, 1 hit |
InterProi | View protein in InterPro IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF00082, Peptidase_S8, 1 hit PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8YGD1_HUMAN | |
Accessioni | A0A2R8YGD1Primary (citable) accession number: A0A2R8YGD1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | December 2, 2020 | |
This is version 13 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |