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UniProtKB - A0A2R8YF72 (A0A2R8YF72_HUMAN)
Protein
Submitted name:
Myelin transcription factor 1-like protein
Gene
MYT1L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Myelin transcription factor 1-like proteinImported |
Gene namesi | Name:MYT1LImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7623, MYT1L |
VEuPathDBi | HostDB:ENSG00000186487 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 621 – 872 | MYT1InterPro annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 56 – 175 | DisorderedSequence analysisAdd BLAST | 120 | |
Regioni | 220 – 247 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 342 – 372 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 449 – 513 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 659 – 709 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 753 – 780 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1079 – 1148 | Sequence analysisAdd BLAST | 70 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 89 – 169 | Acidic residuesSequence analysisAdd BLAST | 81 | |
Compositional biasi | 342 – 358 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 449 – 507 | Basic and acidic residuesSequence analysisAdd BLAST | 59 | |
Compositional biasi | 684 – 709 | Polar residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the MYT1 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155671 |
Family and domain databases
InterProi | View protein in InterPro IPR013681, Myelin_TF IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF08474, MYT1, 1 hit PF01530, zf-C2HC, 7 hits |
SUPFAMi | SSF103637, SSF103637, 7 hits |
PROSITEi | View protein in PROSITE PS51802, ZF_CCHHC, 7 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 35 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8YF72-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVDTEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC DDSDGTEDMD
110 120 130 140 150
EKEEDEGEEY SEDNDEPGDE DEEDEEGDRE EEEEIEEEDE DDDEDGEDVE
160 170 180 190 200
DEEEEEEEEE EEEEEEENED HQMNCHNTRI MQDTEKDDNN NDEYDNYDEL
210 220 230 240 250
VAKSLLNLGK IAEDAAYRAR TESEMNSNTS NSLEDDSDKN ENLGRKSELS
260 270 280 290 300
LDLDSDVVRE TVDSLKLLAQ GHGVVLSENM NDRNYADSMS QQDSRNMNYV
310 320 330 340 350
MLGKPMNNGL MEKMVEESDE EVCLSSLECL RNQCFDLARK LSETNPQERN
360 370 380 390 400
PQQNMNIRQH VRPEEDFPGR TPDRNYSDML NLMRLEEQLS PRSRVFASCA
410 420 430 440 450
KEDGCHERDD DTTSVNSDRS EEVFDMTKGN LTLLEKAIAL ETERAKAMRE
460 470 480 490 500
KMAMEAGRRD NMRSYEDQSP RQLPGEDRKP KSSDSHVKKP YYGKDPSRTE
510 520 530 540 550
KKESKCPTPG CDGTGHVTGL YPHHRSLSGC PHKDRVPPEI LAMHESVLKC
560 570 580 590 600
PTPGCTGRGH VNSNRNSHRS LSGCPIAAAE KLAKAQEKHQ SCDVSKSSQA
610 620 630 640 650
SDRVLRPMCF VKQLEIPQYG YRNNVPTTTP RSNLAKELEK YSKTSFEYNS
660 670 680 690 700
YDNHTYGKRA IAPKVQTRDI SPKGYDDAKR YCKDPSPSSS STSSYAPSSS
710 720 730 740 750
SNLSCGGGSS ASSTCSKSSF DYTHDMEAAH MAATAILNLS TRCREMPQNL
760 770 780 790 800
STKPQDLCAT RNPDMEVDEN GTLDLSMNKQ RPRDSCCPIL TPLEPMSPQQ
810 820 830 840 850
QAVMNNRCFQ LGEGDCWDLP VDYTKMKPRR IDEDESKDIT PEDLDPFQEA
860 870 880 890 900
LEERRYPGEV TIPSPKPKYP QCKESKKDLI TCPTPGCDGS GHVTGNYASH
910 920 930 940 950
RSLSGCPLAD KSIRSMLATS SQELKCPTPG CDGSGHITGN YASHRSLSGC
960 970 980 990 1000
PRAKKSGIRI AQSKEDKEDQ EPIRCPVPGC DGQGHITGKY ASHRSASGCP
1010 1020 1030 1040 1050
LAAKRQKDGY LNGSQFSWKS VKTEGMSCPT PGCDGSGHVS GSFLTHRSLS
1060 1070 1080 1090 1100
GCPRATSAMK KAKLSGEQML TIKQRASNGI ENDEEIKQLD EEIKELNESN
1110 1120 1130 1140 1150
SQMEADMIKL RTQITTMESN LKTIEEENKV IEQQNESLLH ELANLSQSLI
1160 1170 1180 1190 1200
HSLANIQLPH MDPINEQNFD AYVTTLTEMY TNQDRYQSPE NKALLENIKQ
AVRGIQV
Computationally mapped potential isoform sequencesi
There are 35 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UL68 | MYT1L_HUMAN | Myelin transcription factor 1-like ... | MYT1L KIAA1106 | 1,186 | Annotation score: | ||
A0A3B3IRM3 | A0A3B3IRM3_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 1,143 | Annotation score: | ||
A0A3B3IRX5 | A0A3B3IRX5_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 1,146 | Annotation score: | ||
A0A3B3IS14 | A0A3B3IS14_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 1,186 | Annotation score: | ||
A0A3B3IS61 | A0A3B3IS61_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 1,148 | Annotation score: | ||
A0A3B3ISW5 | A0A3B3ISW5_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 1,143 | Annotation score: | ||
A0A3B3IRF0 | A0A3B3IRF0_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 668 | Annotation score: | ||
A0A3B3IRT9 | A0A3B3IRT9_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 1,127 | Annotation score: | ||
A0A3B3ISN3 | A0A3B3ISN3_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 824 | Annotation score: | ||
A0A3B3ITJ8 | A0A3B3ITJ8_HUMAN | Myelin transcription factor 1-like ... | MYT1L | 1,185 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008276 Genomic DNA No translation available. AC009232 Genomic DNA No translation available. AC009471 Genomic DNA No translation available. AC011301 Genomic DNA No translation available. AC093390 Genomic DNA No translation available. AC106046 Genomic DNA No translation available. |
RefSeqi | XP_011508626.1, XM_011510324.1 |
Genome annotation databases
Ensembli | ENST00000644820; ENSP00000496210; ENSG00000186487 |
GeneIDi | 23040 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008276 Genomic DNA No translation available. AC009232 Genomic DNA No translation available. AC009471 Genomic DNA No translation available. AC011301 Genomic DNA No translation available. AC093390 Genomic DNA No translation available. AC106046 Genomic DNA No translation available. |
RefSeqi | XP_011508626.1, XM_011510324.1 |
3D structure databases
SMRi | A0A2R8YF72 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A2R8YF72 |
Protocols and materials databases
Antibodypediai | 62900, 59 antibodies from 24 providers |
DNASUi | 23040 |
Genome annotation databases
Ensembli | ENST00000644820; ENSP00000496210; ENSG00000186487 |
GeneIDi | 23040 |
Organism-specific databases
CTDi | 23040 |
HGNCi | HGNC:7623, MYT1L |
OpenTargetsi | ENSG00000186487 |
VEuPathDBi | HostDB:ENSG00000186487 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155671 |
Miscellaneous databases
ChiTaRSi | MYT1L, human |
Gene expression databases
ExpressionAtlasi | A0A2R8YF72, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR013681, Myelin_TF IPR002515, Znf_C2H2C IPR036060, Znf_C2H2C_sf |
Pfami | View protein in Pfam PF08474, MYT1, 1 hit PF01530, zf-C2HC, 7 hits |
SUPFAMi | SSF103637, SSF103637, 7 hits |
PROSITEi | View protein in PROSITE PS51802, ZF_CCHHC, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8YF72_HUMAN | |
Accessioni | A0A2R8YF72Primary (citable) accession number: A0A2R8YF72 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | January 19, 2022 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |