UniProtKB - A0A2R8YD45 (A0A2R8YD45_HUMAN)
Protein
Submitted name:
Tripeptidyl-peptidase 1
Gene
TPP1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Cofactori
Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per subunit.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 454 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 455 | Calcium; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 478 | Calcium; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 480 | CalciumPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-UniRule
- serine-type endopeptidase activity Source: InterPro
Keywordsi
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Tripeptidyl-peptidase 1Imported |
Gene namesi | Name:TPP1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2073, TPP1 |
Subcellular locationi
Lysosome
- lysosome Source: UniProtKB-KW
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015335471 | 22 – 500 | Sequence analysisAdd BLAST | 479 |
Proteomic databases
PeptideAtlasi | A0A2R8YD45 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 500 | Peptidase S53InterPro annotationAdd BLAST | 356 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00390000008684 |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 2 hits |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8YD45-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT
60 70 80 90 100
FALRQQNVER LSELVQAVSD PSSPQYGKYL TLENVADLVR PSPLTLHTVQ
110 120 130 140 150
KWLLAAGAQK CHSVITQDFL TCWLSIRQAE LLLPGAEFHH YVGGPTETHV
160 170 180 190 200
VRSPHPYQLP QALAPHVDFV GGLHRFPPTS SLRQRPEPQV TGTVGLHLGV
210 220 230 240 250
TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL AQFMRLFGGN
260 270 280 290 300
FAHQASVARV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGDSGA
310 320 330 340 350
GCWSVSGRHQ FRPTFPASSP YVTTVGGTSF QEPFLITNEI VDYISGGGFS
360 370 380 390 400
NVFPRPSYQE EAVTKFLSSS PHLPPSSYFN ASGRAYPDVA ALSDGYWVVS
410 420 430 440 450
NRVPIPWVSG TSASTPVFGG ILSLINEHRI LSGRPPLGFL NPRLYQQHGA
460 470 480 490 500
GLFDVTRGCH ESCLDEEVEG QGFCSGPGWD PVTGWGTPNF PALLKTLLNP
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14773 | TPP1_HUMAN | Tripeptidyl-peptidase 1 | TPP1 CLN2, GIG1, UNQ267/PRO304 | 563 | Annotation score: | ||
A0A2R8YGD1 | A0A2R8YGD1_HUMAN | Tripeptidyl aminopeptidase | TPP1 | 470 | Annotation score: | ||
A0A2R8Y7U1 | A0A2R8Y7U1_HUMAN | Tripeptidyl aminopeptidase | TPP1 | 400 | Annotation score: | ||
A0A2R8YE64 | A0A2R8YE64_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 162 | Annotation score: | ||
A0A2R8YCK4 | A0A2R8YCK4_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 81 | Annotation score: | ||
A0A2R8Y7I4 | A0A2R8Y7I4_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 162 | Annotation score: | ||
E9PME9 | E9PME9_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 30 | Annotation score: | ||
E9PPA4 | E9PPA4_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 39 | Annotation score: | ||
E7EV34 | E7EV34_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 170 | Annotation score: | ||
A0A2R8YD72 | A0A2R8YD72_HUMAN | Tripeptidyl-peptidase 1 | TPP1 | 92 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091564 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000644218; ENSP00000493574; ENSG00000166340 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC091564 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A2R8YD45 |
Protocols and materials databases
Antibodypediai | 23932, 410 antibodies |
Genome annotation databases
Ensembli | ENST00000644218; ENSP00000493574; ENSG00000166340 |
Organism-specific databases
HGNCi | HGNC:2073, TPP1 |
OpenTargetsi | ENSG00000166340 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000008684 |
Miscellaneous databases
ChiTaRSi | TPP1, human |
Gene expression databases
ExpressionAtlasi | A0A2R8YD45, baseline and differential |
Family and domain databases
CDDi | cd04056, Peptidases_S53, 1 hit cd11377, Pro-peptidase_S53, 1 hit |
Gene3Di | 3.40.50.200, 2 hits |
InterProi | View protein in InterPro IPR036852, Peptidase_S8/S53_dom_sf IPR015366, S53_propep IPR030400, Sedolisin_dom |
Pfami | View protein in Pfam PF09286, Pro-kuma_activ, 1 hit |
SMARTi | View protein in SMART SM00944, Pro-kuma_activ, 1 hit |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS51695, SEDOLISIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8YD45_HUMAN | |
Accessioni | A0A2R8YD45Primary (citable) accession number: A0A2R8YD45 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | December 2, 2020 | |
This is version 13 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |