UniProtKB - A0A2R8YD30 (A0A2R8YD30_HUMAN)
Protein
Submitted name:
Erythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked), isoform CRA_e
Gene
EPB41
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
- structural molecule activity Source: InterPro
GO - Biological processi
- cortical actin cytoskeleton organization Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Erythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked), isoform CRA_eImportedSubmitted name: Protein 4.1Imported |
Gene namesi | Name:EPB41Imported ORF Names:hCG_23375Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3377 EPB41 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 282 | FERMInterPro annotationAdd BLAST | 282 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 309 – 363 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 377 – 402 | DisorderedSequence analysisAdd BLAST | 26 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 462 – 482 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157833 |
Family and domain databases
CDDi | cd14473 FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379 Band_4.1_C IPR019749 Band_41_domain IPR021187 Band_41_protein_chordates IPR000798 Ez/rad/moesin-like IPR014847 FERM-adjacent IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR011993 PH-like_dom_sf IPR007477 SAB_dom IPR029071 Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12 PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902 4_1_CTD, 1 hit PF08736 FA, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit PF04382 SAB, 1 hit |
PRINTSi | PR00935 BAND41 PR00661 ERMFAMILY |
SMARTi | View protein in SMART SM00295 B41, 1 hit SM01195 FA, 1 hit SM01196 FERM_C, 1 hit |
SUPFAMi | SSF47031 SSF47031, 1 hit SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 23 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8YD30-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED YFGLAIWDNA
60 70 80 90 100
TSKTWLDSAK EIKKQVRGVP WNFTFNVKFY PPDPAQLTED ITRYYLCLQL
110 120 130 140 150
RQDIVAGRLP CSFATLALLG SYTIQSELGD YDPELHGVDY VSDFKLAPNQ
160 170 180 190 200
TKELEEKVME LHKSYRSMTP AQADLEFLEN AKKLSMYGVD LHKAKDLEGV
210 220 230 240 250
DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI KIRPGEQEQY
260 270 280 290 300
ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTIPKSK FLALGSKFRY
310 320 330 340 350
SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV DSADRSPRPT
360 370 380 390 400
SAPAITQGQV AEGGVLDASA KKTVVPKAQK ETVKAEVKKE DEPPEQAEPE
410 420 430 440 450
PTEAWKVEKT HIEVTVPTSN GDQTQKLAEK TEDLIRMRKK KRERLDGENI
460 470 480 490 500
YIRHSNLMLE DLDKSQEEIK KHHASISELK KNFMESVPEP RPSEWDKRLS
510 520 530 540 550
THSPFRTLNI NGQIPTGEGP PLVKTQTVTI SDNANAVKSE IPTKDVPIVH
560 570 580 590 600
TETKTITYEA AQTDDNSGDL DPGVLLTAQT ITSETPSSTT TTQITKTVKG
610 620 630 640 650
GISETRIEKR IVITGDADID HDQVLVQAIK EAKEQHPDMS VTKVVVHQET
EIADE
Computationally mapped potential isoform sequencesi
There are 23 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP11171 | 41_HUMAN | Protein 4.1 | EPB41 E41P | 864 | Annotation score: | ||
Q4VB86 | Q4VB86_HUMAN | EPB41 protein | EPB41 | 622 | Annotation score: | ||
A0A1B0GWG0 | A0A1B0GWG0_HUMAN | Protein 4.1 | EPB41 | 483 | Annotation score: | ||
A0A2R8YCW8 | A0A2R8YCW8_HUMAN | Protein 4.1 | EPB41 | 748 | Annotation score: | ||
A0A3B3IU06 | A0A3B3IU06_HUMAN | Protein 4.1 | EPB41 | 807 | Annotation score: | ||
A0A2R8Y7Y3 | A0A2R8Y7Y3_HUMAN | Protein 4.1 | EPB41 | 601 | Annotation score: | ||
A0A2U3TZH6 | A0A2U3TZH6_HUMAN | Protein 4.1 | EPB41 | 841 | Annotation score: | ||
A0A2R8Y7N0 | A0A2R8Y7N0_HUMAN | Protein 4.1 | EPB41 | 565 | Annotation score: | ||
A0A2R8Y5G2 | A0A2R8Y5G2_HUMAN | Protein 4.1 | EPB41 | 782 | Annotation score: | ||
A0A2R8Y6D0 | A0A2R8Y6D0_HUMAN | Protein 4.1 | EPB41 | 542 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009181 Genomic DNA No translation available. AL138785 Genomic DNA No translation available. AL357500 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07666.1 |
Genome annotation databases
Ensembli | ENST00000642937; ENSP00000494212; ENSG00000159023 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009181 Genomic DNA No translation available. AL138785 Genomic DNA No translation available. AL357500 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07666.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A2R8YD30 |
Genome annotation databases
Ensembli | ENST00000642937; ENSP00000494212; ENSG00000159023 |
Organism-specific databases
HGNCi | HGNC:3377 EPB41 |
OpenTargetsi | ENSG00000159023 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157833 |
Miscellaneous databases
ChiTaRSi | EPB41 human |
Gene expression databases
ExpressionAtlasi | A0A2R8YD30 baseline and differential |
Family and domain databases
CDDi | cd14473 FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379 Band_4.1_C IPR019749 Band_41_domain IPR021187 Band_41_protein_chordates IPR000798 Ez/rad/moesin-like IPR014847 FERM-adjacent IPR014352 FERM/acyl-CoA-bd_prot_sf IPR035963 FERM_2 IPR019748 FERM_central IPR019747 FERM_CS IPR000299 FERM_domain IPR018979 FERM_N IPR018980 FERM_PH-like_C IPR011993 PH-like_dom_sf IPR007477 SAB_dom IPR029071 Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12 PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902 4_1_CTD, 1 hit PF08736 FA, 1 hit PF09380 FERM_C, 1 hit PF00373 FERM_M, 1 hit PF09379 FERM_N, 1 hit PF04382 SAB, 1 hit |
PRINTSi | PR00935 BAND41 PR00661 ERMFAMILY |
SMARTi | View protein in SMART SM00295 B41, 1 hit SM01195 FA, 1 hit SM01196 FERM_C, 1 hit |
SUPFAMi | SSF47031 SSF47031, 1 hit SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660 FERM_1, 1 hit PS00661 FERM_2, 1 hit PS50057 FERM_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8YD30_HUMAN | |
Accessioni | A0A2R8YD30Primary (citable) accession number: A0A2R8YD30 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | October 16, 2019 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |