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UniProtKB - A0A2R8YD30 (A0A2R8YD30_HUMAN)
Protein
Band 4.1
Gene
EPB41
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- structural molecule activity Source: InterPro
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cortical actin cytoskeleton organization Source: InterPro
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation |
Biological process | Cell cycle, Cell division, MitosisARBA annotation, TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Band 4.1ARBA annotationAlternative name(s): Erythrocyte membrane protein band 4.1ARBA annotation Protein 4.1ARBA annotation |
Gene namesi | Name:EPB41Imported ORF Names:hCG_23375Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3377, EPB41 |
VEuPathDBi | HostDB:ENSG00000159023 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Other locations
- cell cortex ARBA annotation
Cytoskeleton
- cytoskeleton Source: InterPro
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
Interactioni
GO - Molecular functioni
- actin binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 282 | FERMInterPro annotationAdd BLAST | 282 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 309 – 363 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 377 – 402 | DisorderedSequence analysisAdd BLAST | 26 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 462 – 482 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157833 |
OMAi | EHHTFFX |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 22 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8YD30-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED YFGLAIWDNA
60 70 80 90 100
TSKTWLDSAK EIKKQVRGVP WNFTFNVKFY PPDPAQLTED ITRYYLCLQL
110 120 130 140 150
RQDIVAGRLP CSFATLALLG SYTIQSELGD YDPELHGVDY VSDFKLAPNQ
160 170 180 190 200
TKELEEKVME LHKSYRSMTP AQADLEFLEN AKKLSMYGVD LHKAKDLEGV
210 220 230 240 250
DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI KIRPGEQEQY
260 270 280 290 300
ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTIPKSK FLALGSKFRY
310 320 330 340 350
SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV DSADRSPRPT
360 370 380 390 400
SAPAITQGQV AEGGVLDASA KKTVVPKAQK ETVKAEVKKE DEPPEQAEPE
410 420 430 440 450
PTEAWKVEKT HIEVTVPTSN GDQTQKLAEK TEDLIRMRKK KRERLDGENI
460 470 480 490 500
YIRHSNLMLE DLDKSQEEIK KHHASISELK KNFMESVPEP RPSEWDKRLS
510 520 530 540 550
THSPFRTLNI NGQIPTGEGP PLVKTQTVTI SDNANAVKSE IPTKDVPIVH
560 570 580 590 600
TETKTITYEA AQTDDNSGDL DPGVLLTAQT ITSETPSSTT TTQITKTVKG
610 620 630 640 650
GISETRIEKR IVITGDADID HDQVLVQAIK EAKEQHPDMS VTKVVVHQET
EIADE
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP11171 | EPB41_HUMAN | Protein 4.1 | EPB41 E41P | 864 | Annotation score: | ||
A0A2R8YCW8 | A0A2R8YCW8_HUMAN | Band 4.1 | EPB41 | 748 | Annotation score: | ||
A0A3B3IU06 | A0A3B3IU06_HUMAN | Band 4.1 | EPB41 | 807 | Annotation score: | ||
A0A1B0GWG0 | A0A1B0GWG0_HUMAN | Band 4.1 | EPB41 | 483 | Annotation score: | ||
A0A2R8Y7Y3 | A0A2R8Y7Y3_HUMAN | Band 4.1 | EPB41 | 601 | Annotation score: | ||
A0A2U3TZH6 | A0A2U3TZH6_HUMAN | Band 4.1 | EPB41 | 841 | Annotation score: | ||
A0A2R8Y7N0 | A0A2R8Y7N0_HUMAN | Band 4.1 | EPB41 | 565 | Annotation score: | ||
A0A2R8Y5G2 | A0A2R8Y5G2_HUMAN | Band 4.1 | EPB41 | 782 | Annotation score: | ||
A0A2R8Y6D0 | A0A2R8Y6D0_HUMAN | Band 4.1 | EPB41 | 542 | Annotation score: | ||
A0A2R8Y570 | A0A2R8Y570_HUMAN | Band 4.1 | EPB41 | 766 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009181 Genomic DNA No translation available. AL138785 Genomic DNA No translation available. AL357500 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07666.1 |
Genome annotation databases
Ensembli | ENST00000642937; ENSP00000494212; ENSG00000159023 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL009181 Genomic DNA No translation available. AL138785 Genomic DNA No translation available. AL357500 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07666.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 30998, 359 antibodies from 30 providers |
Genome annotation databases
Ensembli | ENST00000642937; ENSP00000494212; ENSG00000159023 |
Organism-specific databases
HGNCi | HGNC:3377, EPB41 |
OpenTargetsi | ENSG00000159023 |
VEuPathDBi | HostDB:ENSG00000159023 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157833 |
OMAi | EHHTFFX |
Miscellaneous databases
ChiTaRSi | EPB41, human |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit |
Gene3Di | 1.20.80.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23280:SF12, PTHR23280:SF12, 2 hits |
Pfami | View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit |
PRINTSi | PR00935, BAND41 PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8YD30_HUMAN | |
Accessioni | A0A2R8YD30Primary (citable) accession number: A0A2R8YD30 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | January 19, 2022 | |
This is version 22 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |