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UniProtKB - A0A2R8Y7U0 (A0A2R8Y7U0_HUMAN)
Protein
Submitted name:
GATOR complex protein DEPDC5
Gene
DEPDC5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activator activity Source: InterPro
GO - Biological processi
- intracellular signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: GATOR complex protein DEPDC5Imported |
Gene namesi | Name:DEPDC5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18423, DEPDC5 |
VEuPathDBi | HostDB:ENSG00000100150 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1173 – 1248 | DEPInterPro annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 427 – 450 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 498 – 535 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 704 – 728 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1019 – 1043 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1066 – 1085 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1118 – 1153 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 427 – 443 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 503 – 535 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1070 – 1085 | Polar residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00390000016559 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR045838, DEPDC5_CTD IPR027244, IML1 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR13179, PTHR13179, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF19418, DEPDC5_CTD, 1 hit PF12257, IML1, 1 hit |
SMARTi | View protein in SMART SM00049, DEP, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 27 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8Y7U0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTTKVYKLV IHKKGFGGSD DELVVNPKVF PHIKLGDIVE IAHPNDEYSP
60 70 80 90 100
LLLQVKSLKE DLQKETISVD QTVTQVFRLR PYQDVYVNVV DPKDVTLDLV
110 120 130 140 150
ELTFKDQYIG RGDMWRLKKS LVSTCAYITQ KVEFAGIRAQ AGELWVKNEK
160 170 180 190 200
VMCGYISEDT RVVFRSTSAM VYIFIQMSCE MWDFDIYGDL YFEKAVNGFL
210 220 230 240 250
ADLFTKWKEK NCSHEVTVVL FSRTFYDAKS VDEFPEINRA SIRQDHKGRF
260 270 280 290 300
YEDFYKVVVQ NERREEWTSL LVTIKKLFIQ YPVLVRLEQA EGFPQGDNST
310 320 330 340 350
SAQGNYLEAI NLSFNVFDKH YINRNFDRTG QMSVVITPGV GVFEVDRLLM
360 370 380 390 400
ILTKQRMIDN GIGVDLVCMG EQPLHAVPLF KLHNRSAPRD SRLGDDYNIP
410 420 430 440 450
HWINHSFYTS KSQLFCNSFT PRIKLAGKKP ASEKAKNGRD TSLGSPKESE
460 470 480 490 500
NALPIQVDYD AYDAQVFRLP GPSRAQCLTT CRFSARFTWG SVRERESHSR
510 520 530 540 550
KSASSCDVSS SPSLPSRTLP TEEVRSQASD DSSLGKSANI LMIPHPHLHQ
560 570 580 590 600
YEVSSSLGYT STRDVLENMM EPPQRDSSAP GRFHVGSAES MLHVRPGGYT
610 620 630 640 650
PQRALINPFA PSRMPMKLTS NRRRWMHTFP VGPSGEAIQI HHQTRQNMAE
660 670 680 690 700
LQGSGQRDPT HSSAELLELA YHEAAGRHSN SRQPGDGMSF LNFSGTEELS
710 720 730 740 750
VGLLSNSGAG MNPRTQNKDS LEDSVSTSPD PILTLSAPPV VPGFCCTVGV
760 770 780 790 800
DWKSLTTPAC LPLTTDYFPD RQGLQNDYTE GCYDLLPEAD IDRRDEDGVQ
810 820 830 840 850
MTAQQVFEEF ICQRLMQGYQ IIVQPKTQKP NPAVPPPLSS SPLYSRGLVS
860 870 880 890 900
RNRPEEEDQY WLSMGRTFHK VTLKDKMITV TRYLPKYPYE SAQIHYTYSL
910 920 930 940 950
CPSHSDSEFV SCWVEFSHER LEEYKWNYLD QYICSAGSED FSLIESLKFW
960 970 980 990 1000
RTRFLLLPAC VTATKRITEG EAHCDIYGDR PRADEDEWQL LDGFVRFVEG
1010 1020 1030 1040 1050
LNRIRRRHRS DRMMRKGTAM KGLQMTGPIS THSLESTAPP VGKKGTSALS
1060 1070 1080 1090 1100
ALLEMEASQK CLGEQQAAVH GGKSSAQSAE SSSVAMTPTY MDSPRKVSVD
1110 1120 1130 1140 1150
QTATPMLDGT SLGICTGQSM DRGNSQTFGN SQNIGEQGYS STNSSDSSSQ
1160 1170 1180 1190 1200
QLVASSLTSS STLTEILEAM KHPSTGVQLL SEQKGLSPYC FISAEVVHWL
1210 1220 1230 1240 1250
VNHVEGIQTQ AMAIDIMQKM LEEQLITHAS GEAWRTFIYG FYFYKIVTDK
1260 1270 1280 1290 1300
EPDRVAMQQP ATTWHTAGVD DFASFQRKWF EVAFVAEELV HSEIPAFLLP
1310 1320 1330 1340 1350
WLPSRPASYA SRHSSFSRSF GGRSQAAALL AATVPEQRTV TLDVDVNNRT
1360 1370 1380 1390 1400
DRLEWCSCYY HGNFSLNAAF EIKLHWMAVT AAVLFEMVQG WHRKATSCGF
1410 1420 1430 1440 1450
LLVPVLEGPF ALPSYLYGDP LRAQLFIPLN ISCLLKEGSE HLFDSFEPET
1460 1470 1480 1490 1500
YWDRMHLFQE AIAHRFGFVQ DKYSASAFNF PAENKPQYIH VTGTVFLQLP
1510 1520 1530 1540 1550
YSKRKFSGQQ RRRRNSTSST NQNMFCEERV GYNWAYNTML TKTWRSSATG
1560 1570 1580
DEKFADRLLK DFTDFCINRD NRLVTFWTSC LEKMHASAP
Computationally mapped potential isoform sequencesi
There are 27 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO75140 | DEPD5_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 KIAA0645 | 1,603 | Annotation score: | ||
A0A5F9UWT1 | A0A5F9UWT1_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 1,343 | Annotation score: | ||
H0Y770 | H0Y770_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 1,575 | Annotation score: | ||
A0A2R8Y721 | A0A2R8Y721_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 1,496 | Annotation score: | ||
A0A2R8Y5K9 | A0A2R8Y5K9_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 1,484 | Annotation score: | ||
A0A2R8Y6H3 | A0A2R8Y6H3_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 1,525 | Annotation score: | ||
H7C1T0 | H7C1T0_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 659 | Annotation score: | ||
A0A2R8Y5E9 | A0A2R8Y5E9_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 795 | Annotation score: | ||
A0A2R8Y5P2 | A0A2R8Y5P2_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 531 | Annotation score: | ||
A0A2R8Y7U6 | A0A2R8Y7U6_HUMAN | GATOR complex protein DEPDC5 | DEPDC5 | 829 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005004 Genomic DNA No translation available. AL022331 Genomic DNA No translation available. Z82190 Genomic DNA No translation available. Z83856 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000645407; ENSP00000496252; ENSG00000100150 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005004 Genomic DNA No translation available. AL022331 Genomic DNA No translation available. Z82190 Genomic DNA No translation available. Z83856 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A2R8Y7U0 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A2R8Y7U0 |
Protocols and materials databases
Antibodypediai | 65139, 74 antibodies from 19 providers |
Genome annotation databases
Ensembli | ENST00000645407; ENSP00000496252; ENSG00000100150 |
Organism-specific databases
HGNCi | HGNC:18423, DEPDC5 |
OpenTargetsi | ENSG00000100150 |
VEuPathDBi | HostDB:ENSG00000100150 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000016559 |
Miscellaneous databases
ChiTaRSi | DEPDC5, human |
Gene expression databases
ExpressionAtlasi | A0A2R8Y7U0, baseline and differential |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR045838, DEPDC5_CTD IPR027244, IML1 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR13179, PTHR13179, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF19418, DEPDC5_CTD, 1 hit PF12257, IML1, 1 hit |
SMARTi | View protein in SMART SM00049, DEP, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8Y7U0_HUMAN | |
Accessioni | A0A2R8Y7U0Primary (citable) accession number: A0A2R8Y7U0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | January 19, 2022 | |
This is version 17 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |