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UniProtKB - A0A2R8Y5Z1 (A0A2R8Y5Z1_HUMAN)
Protein
Submitted name:
Catenin beta-1
Gene
CTNNB1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cadherin binding Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Catenin beta-1Imported |
Gene namesi | Name:CTNNB1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2514, CTNNB1 |
VEuPathDBi | HostDB:ENSG00000168036 |
Subcellular locationi
Other locations
- adherens junction ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProt
Other locations
- adherens junction Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junctionARBA annotation, Cytoplasm, CytoskeletonARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 144 – 184 | ARMPROSITE-ProRule annotationAdd BLAST | 41 | |
Repeati | 186 – 229 | ARMPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 228 – 270 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 270 – 312 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 312 – 355 | ARMPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 393 – 435 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 435 – 477 | ARMPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 565 – 607 | ARMPROSITE-ProRule annotationAdd BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 52 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 676 – 752 | DisorderedSequence analysisAdd BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 27 – 41 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the beta-catenin family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155471 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 2 hits |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 11 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 8 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8Y5Z1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELDMAMEPD RKAAVSHWQQ QSYLDSGIHS GATTTAPSLS GKGNPEEEDV
60 70 80 90 100
DTSQVLYEWE QGFSQSFTQE QVADIDGQYA MTRAQRVRAA MFPETLDEGM
110 120 130 140 150
QIPSTQFDAA HPTNVQRLAE PSQMLKHAVV NLINYQDDAE LATRAIPELT
160 170 180 190 200
KLLNDEDQVV VNKAAVMVHQ LSKKEASRHA IMRSPQMVSA IVRTMQNTND
210 220 230 240 250
VETARCTAGT LHNLSHHREG LLAIFKSGGI PALVKMLGSP VDSVLFYAIT
260 270 280 290 300
TLHNLLLHQE GAKMAVRLAG GLQKMVALLN KTNVKFLAIT TDCLQILAYG
310 320 330 340 350
NQESKLIILA SGGPQALVNI MRTYTYEKLL WTTSRVLKVL SVCSSNKPAI
360 370 380 390 400
VEAGGMQALG LHLTDPSQRL VQNCLWTLRN LSDAATKQEG MEGLLGTLVQ
410 420 430 440 450
LLGSDDINVV TCAAGILSNL TCNNYKNKMM VCQVGGIEAL VRTVLRAGDR
460 470 480 490 500
EDITEPAICA LRHLTSRHQE AEMAQNAVRL HYGLPVVVKL LHPPSHWPLI
510 520 530 540 550
KGAIPRLVQL LVRAHQDTQR RTSMGGTQQQ FVEGVRMEEI VEGCTGALHI
560 570 580 590 600
LARDVHNRIV IRGLNTIPLF VQLLYSPIEN IQRVAAGVLC ELAQDKEAAE
610 620 630 640 650
AIEAEGATAP LTELLHSRNE GVATYAAAVL FRMSEDKPQD YKKRLSVELT
660 670 680 690 700
SSLFRTEPMA WNETADLGLD IGAQGEPLGY RQDDPSYRSF HSGGYGQDAL
710 720 730 740 750
GMDPMMEHEM GGHHPGADYP VDGLPDLGHA QDLMDGLPPG DSNQLAWFDT
DL
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP35222 | CTNB1_HUMAN | Catenin beta-1 | CTNNB1 CTNNB, OK/SW-cl.35, PRO2286 | 781 | Annotation score: | ||
B4DGU4 | B4DGU4_HUMAN | Catenin beta-1 | CTNNB1 | 774 | Annotation score: | ||
A0A2R8Y804 | A0A2R8Y804_HUMAN | Catenin beta-1 | CTNNB1 | 702 | Annotation score: | ||
A0A2R8YCH5 | A0A2R8YCH5_HUMAN | Catenin beta-1 | CTNNB1 | 779 | Annotation score: | ||
A0A2R8Y5A3 | A0A2R8Y5A3_HUMAN | Catenin beta-1 | CTNNB1 | 783 | Annotation score: | ||
A0A2R8Y5C3 | A0A2R8Y5C3_HUMAN | Catenin beta-1 | CTNNB1 | 737 | Annotation score: | ||
A0A2R8Y750 | A0A2R8Y750_HUMAN | Catenin beta-1 | CTNNB1 | 744 | Annotation score: | ||
A0A2R8Y7Z0 | A0A2R8Y7Z0_HUMAN | Catenin beta-1 | CTNNB1 | 780 | Annotation score: | ||
A0A2R8Y543 | A0A2R8Y543_HUMAN | Catenin beta-1 | CTNNB1 | 715 | Annotation score: | ||
A0A2R8Y815 | A0A2R8Y815_HUMAN | Catenin beta-1 | CTNNB1 | 186 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104307 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000647264; ENSP00000494849; ENSG00000168036 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104307 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A2R8Y5Z1 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A2R8Y5Z1 |
Protocols and materials databases
Antibodypediai | 3432, 4946 antibodies from 57 providers |
Genome annotation databases
Ensembli | ENST00000647264; ENSP00000494849; ENSG00000168036 |
Organism-specific databases
HGNCi | HGNC:2514, CTNNB1 |
OpenTargetsi | ENSG00000168036 |
VEuPathDBi | HostDB:ENSG00000168036 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155471 |
Miscellaneous databases
ChiTaRSi | CTNNB1, human |
Gene expression databases
ExpressionAtlasi | A0A2R8Y5Z1, baseline and differential |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin |
PANTHERi | PTHR45976, PTHR45976, 2 hits |
Pfami | View protein in Pfam PF00514, Arm, 4 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 11 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 8 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8Y5Z1_HUMAN | |
Accessioni | A0A2R8Y5Z1Primary (citable) accession number: A0A2R8Y5Z1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | January 19, 2022 | |
This is version 20 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |