UniProtKB - A0A2R8Y4W2 (A0A2R8Y4W2_HUMAN)
Protein
Submitted name:
Epidermal growth factor receptor kinase substrate 8
Gene
EPS8
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
- signaling adaptor activity Source: InterPro
GO - Biological processi
- actin filament bundle assembly Source: InterPro
- barbed-end actin filament capping Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Epidermal growth factor receptor kinase substrate 8Imported |
Gene namesi | Name:EPS8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3420, EPS8 |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | A0A2R8Y4W2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 531 – 590 | SH3InterPro annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 202 – 225 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 298 – 320 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 620 – 697 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 794 – 830 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 34 | PolarSequence analysisAdd BLAST | 34 | |
Compositional biasi | 206 – 220 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 625 – 654 | Pro-richSequence analysisAdd BLAST | 30 | |
Compositional biasi | 659 – 676 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 682 – 697 | PolyampholyteSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the EPS8 family.ARBA annotation
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156403 |
OMAi | EEGQLWM |
Family and domain databases
CDDi | cd01210, PTB_EPS8, 1 hit cd11764, SH3_Eps8, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR030222, EPS8 IPR039801, EPS8-like IPR033928, EPS8_PTB IPR035462, Eps8_SH3 IPR011993, PH-like_dom_sf IPR013625, PTB IPR006020, PTB/PI_dom IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12287, PTHR12287, 1 hit PTHR12287:SF21, PTHR12287:SF21, 1 hit |
Pfami | View protein in Pfam PF08416, PTB, 1 hit PF18016, SAM_3, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8Y4W2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGHISNHPS SFGMYPSQMN GYGSSPTFSQ TDREHGSKTS AKALYEQRKN
60 70 80 90 100
YARDSVSSVS DISQYRVEHL TTFVLDRKDA MITVDDGIRK LKLLDAKGKV
110 120 130 140 150
WTQDMILQVD DRAVSLIDLE SKNELENFPL NTIQHCQAVM HSCSYDSVLA
160 170 180 190 200
LVCKEPTQNK PDLHLFQCDE VKANLISEDI ESAISDSKGG KQKRRPDALR
210 220 230 240 250
MISNADPSIP PPPRAPAPAP PGTVTQVDVR SRVAAWSAWA ADQGDFEKPR
260 270 280 290 300
QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR
310 320 330 340 350
KKNKKGKRKG PGEGVLTLRA KPPPPDEFLD CFQKFKHGFN LLAKLKSHIQ
360 370 380 390 400
NPSAADLVHF LFTPLNMVVQ ATGGPELASS VLSPLLNKDT IDFLNYTVNG
410 420 430 440 450
DERQLWMSLG GTWMKARAEW PKEQFIPPYV PRFRNGWEPP MLNFMGATME
460 470 480 490 500
QDLYQLAESV ANVAEHQRKQ EIKRLSTEHS SVSEYHPADG YAFSSNIYTR
510 520 530 540 550
GSHLDQGEAA VAFKPTSNRH IDRNYEPLKT QPKKYAKSKY DFVARNNSEL
560 570 580 590 600
SVLKDDILEI LDDRKQWWKV RNASGDSGFV PNNILDIVRP PESGLGRADP
610 620 630 640 650
PYTHTIQQLL GELSEKQRME YGPRPADTPP APSPPPTPAP VPVPLPPSTP
660 670 680 690 700
APVPVSKVPA NITRQNSSSS DSGGSIVRDS QRHKQLPVDR RKSQMEEVQD
710 720 730 740 750
ELIHRLTIGR SAAQKKFHVP RQNVPVINIT YDSTPEDVKT WLQSKGFNPV
760 770 780 790 800
TVNSLGVLNG AQLFSLNKDE LRTVCPEGAR VYSQITVQKA ALEDSSGSSE
810 820 830
LQEIMRRRQE KISAAASDSG VESFDEGSSH
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ12929 | EPS8_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 822 | Annotation score: | ||
A0A2R8YE63 | A0A2R8YE63_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 839 | Annotation score: | ||
F5H0R8 | F5H0R8_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 200 | Annotation score: | ||
F5H3Q6 | F5H3Q6_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 128 | Annotation score: | ||
F5GYM8 | F5GYM8_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 120 | Annotation score: | ||
F5H2B8 | F5H2B8_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 68 | Annotation score: | ||
H0YFG1 | H0YFG1_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 68 | Annotation score: | ||
F5H1B5 | F5H1B5_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 67 | Annotation score: | ||
F5H714 | F5H714_HUMAN | Epidermal growth factor receptor ki... | EPS8 | 41 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022073 Genomic DNA No translation available. AC073651 Genomic DNA No translation available. AC092753 Genomic DNA No translation available. KF455605 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000646123; ENSP00000494338; ENSG00000151491 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022073 Genomic DNA No translation available. AC073651 Genomic DNA No translation available. AC092753 Genomic DNA No translation available. KF455605 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A2R8Y4W2 |
Protocols and materials databases
Antibodypediai | 1288, 377 antibodies |
Genome annotation databases
Ensembli | ENST00000646123; ENSP00000494338; ENSG00000151491 |
Organism-specific databases
HGNCi | HGNC:3420, EPS8 |
OpenTargetsi | ENSG00000151491 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156403 |
OMAi | EEGQLWM |
Miscellaneous databases
ChiTaRSi | EPS8, human |
Gene expression databases
ExpressionAtlasi | A0A2R8Y4W2, baseline and differential |
Family and domain databases
CDDi | cd01210, PTB_EPS8, 1 hit cd11764, SH3_Eps8, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR030222, EPS8 IPR039801, EPS8-like IPR033928, EPS8_PTB IPR035462, Eps8_SH3 IPR011993, PH-like_dom_sf IPR013625, PTB IPR006020, PTB/PI_dom IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12287, PTHR12287, 1 hit PTHR12287:SF21, PTHR12287:SF21, 1 hit |
Pfami | View protein in Pfam PF08416, PTB, 1 hit PF18016, SAM_3, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8Y4W2_HUMAN | |
Accessioni | A0A2R8Y4W2Primary (citable) accession number: A0A2R8Y4W2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | April 7, 2021 | |
This is version 17 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |