UniProtKB - A0A2R8Q9U8 (A0A2R8Q9U8_DANRE)
Protein
Submitted name:
Histamine receptor H2a
Gene
hrh2a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: GO_Central
- histamine receptor activity Source: ZFIN
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-DRE-390650, Histamine receptors R-DRE-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Submitted name: Histamine receptor H2aImported |
Gene namesi | Name:hrh2aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-070531-4, hrh2a |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 30 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 42 – 67 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 79 – 100 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 121 – 142 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 230 – 256 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 268 – 287 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 284 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 264 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158761 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A2R8Q9U8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSQIALAVT LSVLILLTVS GNILVCLAVY ATRRLRNVTN CFIVSLAVTD
60 70 80 90 100
FLLGALVLPF STLYQVTGDW PLGAHFCNIY ISLDVMLCTA SILNLFAISL
110 120 130 140 150
DRYFAVTAPL RYPMLVLPWR VGAILATIWL VSVGVSFVPI HLGWNTRDLS
160 170 180 190 200
VQNIREGDHA RDCRFELNPT YAIVDAFSTF YLPLLAMCWS YHRVFRIARM
210 220 230 240 250
RAKRIISTRR GSTSSQGVTI LTLREHKATV TLAVVLGAFV VCWFPYFTFF
260 270 280 290 300
TIMGIRNEEN PPQTAQSVVL WLGYANSALN PVLYATLNRD FRSAYAKLLC
310 320 330 340 350
GGRRCKTETT IPIAATAAGT MTGHAHSSKG AGFLPRTCVL LKDSENRMLD
360
DNSATNGATV TVVANGSKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01064228 Genomic DNA No translation available. |
RefSeqi | NP_001038803.2, NM_001045338.2 |
Genome annotation databases
Ensembli | ENSDART00000174675; ENSDARP00000151225; ENSDARG00000107444 |
GeneIDi | 735303 |
KEGGi | dre:735303 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01064228 Genomic DNA No translation available. |
RefSeqi | NP_001038803.2, NM_001045338.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSDART00000174675; ENSDARP00000151225; ENSDARG00000107444 |
GeneIDi | 735303 |
KEGGi | dre:735303 |
Organism-specific databases
CTDi | 735303 |
ZFINi | ZDB-GENE-070531-4, hrh2a |
Phylogenomic databases
GeneTreei | ENSGT00940000158761 |
Enzyme and pathway databases
Reactomei | R-DRE-390650, Histamine receptors R-DRE-418555, G alpha (s) signalling events |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8Q9U8_DANRE | |
Accessioni | A0A2R8Q9U8Primary (citable) accession number: A0A2R8Q9U8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | December 2, 2020 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |