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Entry version 11 (07 Oct 2020)
Sequence version 1 (20 Jun 2018)
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Protein
Submitted name:

IQ motif and Sec7 domain ArfGEF 2a

Gene

iqsec2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IQ motif and Sec7 domain ArfGEF 2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:iqsec2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-170302-3, iqsec2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A2R8Q8W8, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 772SEC7InterPro annotationAdd BLAST194

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni56 – 76DisorderedSequence analysisAdd BLAST21
Regioni183 – 236DisorderedSequence analysisAdd BLAST54
Regioni256 – 281DisorderedSequence analysisAdd BLAST26
Regioni333 – 375DisorderedSequence analysisAdd BLAST43
Regioni388 – 578DisorderedSequence analysisAdd BLAST191
Regioni981 – 1024DisorderedSequence analysisAdd BLAST44
Regioni1042 – 1140DisorderedSequence analysisAdd BLAST99
Regioni1196 – 1294DisorderedSequence analysisAdd BLAST99
Regioni1408 – 1492DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi183 – 226PolarSequence analysisAdd BLAST44
Compositional biasi409 – 429PolarSequence analysisAdd BLAST21
Compositional biasi466 – 488BasicSequence analysisAdd BLAST23
Compositional biasi492 – 507Pro-richSequence analysisAdd BLAST16
Compositional biasi508 – 554PolarSequence analysisAdd BLAST47
Compositional biasi993 – 1015PolarSequence analysisAdd BLAST23
Compositional biasi1070 – 1089PolarSequence analysisAdd BLAST20
Compositional biasi1098 – 1130Pro-richSequence analysisAdd BLAST33
Compositional biasi1196 – 1258Pro-richSequence analysisAdd BLAST63
Compositional biasi1415 – 1451Pro-richSequence analysisAdd BLAST37
Compositional biasi1466 – 1492PolarSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BRAG family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159667

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13318, PH_IQSEC, 1 hit
cd00171, Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR033742, IQSEC_PH
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16453, IQ_SEC7_PH, 1 hit
PF01369, Sec7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00222, Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425, SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit
PS50190, SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A2R8Q8W8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCEFVLSFLA MRFHRKTNLP NRAHAYIVEG DPQCPDTTSF SDSTCSQGPY
60 70 80 90 100
LGNSERYGNI RNIPGPQGPP VGTASPASLA WAQRSRHQPA SLALRKQEEE
110 120 130 140 150
ESKRCKALSD SYELSTDLQD KKVEMLERKY GGYFLSRRAA RTIQTAFRQY
160 170 180 190 200
RMNKNFQRLR SSASESRMTR RIILSNMRSQ YSFDERQPQV QPQTPQQQQG
210 220 230 240 250
RYTSHHTSGT AGQTGSTNTQ QETDSPAHCP SDREEYSHAD DAFNKQVTSL
260 270 280 290 300
ADSMDDTLTC QSGRGDSQDG GEGAREESVD FGECVWSNKP TSRRGVVGEQ
310 320 330 340 350
ERLGVMHEDS TATSYSDVTL YMDDGMPCSP LSIERVPSST DTEYWGVSSG
360 370 380 390 400
VGGREDSRDT EGGGSTNSRR STPCTECRDF RLRGSHLPVL TIEPPSDSSV
410 420 430 440 450
DMSDRSDRGS LSRQLLYEQE PTAGGSPQGT LKHNPAPRMP NPCAAQGQTR
460 470 480 490 500
PTGRPIPSPL PTHLPHHAMM HHHHHPHLHH PLHHHPLPHM HHPYPDPTSP
510 520 530 540 550
SPTQPPLTPL SSSSSAPLPA SGMEQSDGDN DSLNSTTNSN ETINCSSGSS
560 570 580 590 600
SRDSLREPLP PLGKQTYQRE SRHSWDSPAF NNDVVQRRHY RIGLNLFNKK
610 620 630 640 650
PEKGIQYLIE RGFVSDTPVG IARFILERKG LSRQMIGEFL GNRQKQFNKD
660 670 680 690 700
VLDCVLDEMD FSGMDLDDAL RKFQAQIKVQ GEAQKVERLV EAFSQRYCVC
710 720 730 740 750
NPALVRQFQN PDTIFILAFA IILLNTDMYS PNVKAERKMK LEDFIKNLRG
760 770 780 790 800
VDNGQDIPRD LLVGIYQRIQ KWELRTNDDH VSQVQAVERV IVGKKPVLSL
810 820 830 840 850
PHRRLVCCCQ LYEVPDPNRP QRSGVHQREV FLFNDLLVVT KIFQKKKTSV
860 870 880 890 900
TYSFRQSFPL VEMQVHMFQN SYYAHGIRLT SAMPGAERKV LIVFNAPSQQ
910 920 930 940 950
DRTRFTSDLR ESIAEVQDME KYRVESELEK QKGVMRPGLL SGEVSSVGGM
960 970 980 990 1000
KTEAVNGTLG RPSLDDTYAA GEGLKRTALS SSLRDLSDTG KRGRRNSVGS
1010 1020 1030 1040 1050
LDSTIEGSII NSPQPHQRLP MGGAVPGCYG LEDYRPHRPI LSPGVGVGGG
1060 1070 1080 1090 1100
PGQLHNAVGN MVGGSGTSDR GGGPGSSSGG SNSGSFLGSL FGSKRGKPPA
1110 1120 1130 1140 1150
PLIPPGPHYP APVRPPTTGG PPPPSPSALS QSDPGGPSKI QALHAQYCHN
1160 1170 1180 1190 1200
NFGQPPPPYH HHHRYHMQVG APGHPPAMHP PNIHPPAMHP PNIHPPAMHP
1210 1220 1230 1240 1250
PNIHPPAMHP PNIHPPAMHP PNIHPPAMHP PNIHPPAMHP TNMHPPSVHP
1260 1270 1280 1290 1300
PSMHPPSGHP PAMHHTLQRG SLPRRGPAAP SHPQLQQQLS HHAMQQGRYG
1310 1320 1330 1340 1350
NMACTPPPLS PHSPHSPVGP FNFYHVHGNP IRLARVPGPT GKLPLTLSHS
1360 1370 1380 1390 1400
QPHPHAHSHG HSHTHNHLVH VHSPHPELHH SGQTHFVFSP PPQAPSAITA
1410 1420 1430 1440 1450
RHIPQGVSHY IPQYPPLSSI PPPPPHSPLP PPSSPHTPLT PLTPLSPLAP
1460 1470 1480 1490
QLPGPMGAQS GGPGGGGGSG ASNSSTVGSS KSKPINRIST VV
Length:1,492
Mass (Da):163,354
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC66350EB9B1859F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QGT6A0A2R8QGT6_DANRE
IQ motif and Sec7 domain ArfGEF 2a
iqsec2a
1,013Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2L9N5A0A0G2L9N5_DANRE
IQ motif and Sec7 domain ArfGEF 2a
iqsec2a
1,629Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q8B1A0A2R8Q8B1_DANRE
IQ motif and Sec7 domain ArfGEF 2a
iqsec2a
1,487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QUT2A0A2R8QUT2_DANRE
IQ motif and Sec7 domain ArfGEF 2a
iqsec2a
1,281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q462A0A2R8Q462_DANRE
IQ motif and Sec7 domain ArfGEF 2a
iqsec2a
858Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QNV2A0A2R8QNV2_DANRE
IQ motif and Sec7 domain ArfGEF 2a
iqsec2a
825Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR388083 Genomic DNA No translation available.
CT025733 Genomic DNA No translation available.
CT583651 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_017212947.1, XM_017357458.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000188029; ENSDARP00000147771; ENSDARG00000102125

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
560461

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR388083 Genomic DNA No translation available.
CT025733 Genomic DNA No translation available.
CT583651 Genomic DNA No translation available.
RefSeqiXP_017212947.1, XM_017357458.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000188029; ENSDARP00000147771; ENSDARG00000102125
GeneIDi560461

Organism-specific databases

ZFINiZDB-GENE-170302-3, iqsec2a

Phylogenomic databases

GeneTreeiENSGT00940000159667

Gene expression databases

ExpressionAtlasiA0A2R8Q8W8, baseline

Family and domain databases

CDDicd13318, PH_IQSEC, 1 hit
cd00171, Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR033742, IQSEC_PH
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
PfamiView protein in Pfam
PF16453, IQ_SEC7_PH, 1 hit
PF01369, Sec7, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00222, Sec7, 1 hit
SUPFAMiSSF48425, SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS50190, SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R8Q8W8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R8Q8W8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: October 7, 2020
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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