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Entry version 15 (07 Apr 2021)
Sequence version 1 (20 Jun 2018)
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Protein

Methylcytosine dioxygenase TET

Gene

tet3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenaseUniRule annotation, Oxidoreductase
LigandIronUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylcytosine dioxygenase TETUniRule annotation (EC:1.14.11.n2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tet3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060526-109, tet3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A2R8Q5Y7, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1104 – 1795Tet_JBPInterPro annotationAdd BLAST692

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60DisorderedSequence analysisAdd BLAST60
Regioni316 – 412DisorderedSequence analysisAdd BLAST97
Regioni571 – 604DisorderedSequence analysisAdd BLAST34
Regioni633 – 673DisorderedSequence analysisAdd BLAST41
Regioni706 – 740DisorderedSequence analysisAdd BLAST35
Regioni759 – 829DisorderedSequence analysisAdd BLAST71
Regioni1460 – 1640DisorderedSequence analysisAdd BLAST181
Regioni1682 – 1741DisorderedSequence analysisAdd BLAST60
Regioni1843 – 1862DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1280 – 1300Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 49PolyampholyteSequence analysisAdd BLAST21
Compositional biasi706 – 737PolarSequence analysisAdd BLAST32
Compositional biasi772 – 811PolarSequence analysisAdd BLAST40
Compositional biasi812 – 829PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1460 – 1498PolarSequence analysisAdd BLAST39
Compositional biasi1519 – 1536PolarSequence analysisAdd BLAST18
Compositional biasi1555 – 1569PolarSequence analysisAdd BLAST15
Compositional biasi1578 – 1597PolarSequence analysisAdd BLAST20
Compositional biasi1598 – 1639Pro-richSequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TET family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157631

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3

The PANTHER Classification System

More...
PANTHERi
PTHR23358, PTHR23358, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12851, Tet_JBP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01333, Tet_JBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2R8Q5Y7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIGSHERLE EGLLNQELSN GLSKHASNEE NVCDNEDRDA TKEQHQHNFH
60 70 80 90 100
EGAGSISQTP GWVLEHTGKL SNPESQQGVW SGQNASTTVN DVDMEDAQTL
110 120 130 140 150
VAFSVGSLPP YTNHQPSPTP TAQLYERFNQ EMSNGGEEAK KKGVDGAFCP
160 170 180 190 200
PEDLNTLQAA LSKARHGHKP PNCDCDGPDC PDYLEWLEKQ IKLVTNCQNK
210 220 230 240 250
TSCNLSGTAQ QPLEQHHYSQ SQPQQCGGKP LCVQDTNPQP LVNKPSTPRP
260 270 280 290 300
FGPPAPIPCS PSVLSIAKER NVSLQTAIAI EALTQLSATV PQTVVPPGES
310 320 330 340 350
SLANHHQHLP TSYHQNMPQV VSSSPGPLLS SSATSAIPQS NHYPQQELTT
360 370 380 390 400
WEQQRPQSKG EAPTANIFPS SSHYSSSYPS SKPPFTNMHA SSPNPRPQQW
410 420 430 440 450
NQGTASSCEK NSPRNAWMMA NTDSKQHFAK PSHESSDPVS ELKQLLGDTG
460 470 480 490 500
GKHPFKFPFP HPSLQDVHKG SFTGMPHIKQ EVETKEYLGS ECSVMGQEGM
510 520 530 540 550
LNGQQQFQGQ QLSSTIRHST QAALQQHLHH KRNLFSNSPT YGPLAHMACQ
560 570 580 590 600
DLRKWWPQTI PENLINIKQE HKEPKKKKGA QSSHLKQPAG GPFGPLGTPL
610 620 630 640 650
PKPKPIVIKK HKQKASQPTF LPQIQITISK PPLISPGYAP SRAQLVPSLP
660 670 680 690 700
GMEAGLPPTQ VAESHPAPAQ SQESIINCSS APISENSHSS TNPVSVLAPS
710 720 730 740 750
TQKVIACPGS AGSNDSIPTT SITPQTSTTQ PSPSLAGLSN LDPKFEELIR
760 770 780 790 800
QFEEEFGDTA ASAAETPENG PVQPVVTESH PNSGQLRPES PSLKQPNNCP
810 820 830 840 850
PVPTNESEPM NEGQKDIPER QKEKTPLPPE ELCTVKQESE ECALDVKPSG
860 870 880 890 900
ELLSEFLKQQ NPFVAPFSPP NKRMKIESSN GVTVLSTTAC FSADREGDDF
910 920 930 940 950
NTPTKDIFPS SPSLKGFLES PLRYLDTPTK NLLDTPGKDV QPDFPICDCV
960 970 980 990 1000
DQVLEKDEGP YYNHLGSGRD IPSVRQLMED RYGEKGEAVR IEKVVYTGRE
1010 1020 1030 1040 1050
GKSSQGCPIA KWVLRRSSEK EKVLCVVKQR PGHHCANTVI VVVILAWEGV
1060 1070 1080 1090 1100
PRALGDKLYR EVTETITKYG NPTSRRCGLN EDRTCACQGK DPETCGASFS
1110 1120 1130 1140 1150
FGCSWSMYFN GCKYARSKVP RKFRLQGEHP KEEDNLRDNF QALATHVAPL
1160 1170 1180 1190 1200
YKKLAPQAYS NQCLHEDVAS DCRLGLKEGR PFSGITACMD FCAHAHKDQH
1210 1220 1230 1240 1250
NLHNGCTVVC TLTKEDNRTV GTIPEDEQLH VLPLYKLATT DEFGSEENQR
1260 1270 1280 1290 1300
LKMQTGAIQV LANFRREVRK LPEPAKSCRQ RRLEAKKAAS EKKNRKLQLA
1310 1320 1330 1340 1350
ETPEKTVKME IRHAESPHIQ QGNKAIPKQE VKPTIKKEPV DHFQPFNGAI
1360 1370 1380 1390 1400
HGYQALGNGK TNPDPHNMNS SFSYPGNYAR GRIPGNSHPP AQNPINGFHP
1410 1420 1430 1440 1450
NLQDIRYGYY NYPSSALFSP ELLRYDKGAW PKNGEPSAQA FEQKPDVQCL
1460 1470 1480 1490 1500
QANLAQAYPT HHGQSQAQMA DASIQGYPQP SDISQCRTPS MSLEQTHRSK
1510 1520 1530 1540 1550
PIVKQEPMDV PLYEARSDGQ AQSCPTTPST TPTPEGWHGH KPNGSLVPKG
1560 1570 1580 1590 1600
WDGNIRAASN NSPFTPDKQR LHQQHQHEHP QYPQQQQWNS YSCPNTPMAS
1610 1620 1630 1640 1650
PAPSPSPSLK AGLSPAPSPH PSTPRQWGSP APSPQPKAWG PYGPMGYGAG
1660 1670 1680 1690 1700
VIRQGNPAGA YPDNMLSQAG VNCGSAPLGL QEKAWKSGGG SAAGSTPSPA
1710 1720 1730 1740 1750
PEGRLFPDAL QRSDGQACWD SGAETQSERD PEEDEVWSDS EHNFLDPNIG
1760 1770 1780 1790 1800
GVAVAPAHGC VLIECARREL HATTPLKKPD RTHPSRISLV FYQHKNLNQP
1810 1820 1830 1840 1850
CHGLALWESK MKILAERARQ RQQEAALLGL SQEEIKAYGK KRKWAAGSAS
1860 1870 1880 1890
PSPGQTKDKR EGVVTRMAPT QHSTTIVTVS PYPSTHLTGP YSRFV
Length:1,895
Mass (Da):207,543
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i673280B8573F27A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Q4R6A0A2R8Q4R6_DANRE
Methylcytosine dioxygenase TET
tet3
2,052Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2CEA2A2CEA2_DANRE
Methylcytosine dioxygenase TET
tet3
1,101Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR388049 Genomic DNA No translation available.
CT009570 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001314875.1, NM_001327946.1
XP_003198655.2, XM_003198607.4
XP_009299504.1, XM_009301229.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000188456; ENSDARP00000148501; ENSDARG00000062646

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103283056

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR388049 Genomic DNA No translation available.
CT009570 Genomic DNA No translation available.
RefSeqiNP_001314875.1, NM_001327946.1
XP_003198655.2, XM_003198607.4
XP_009299504.1, XM_009301229.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000188456; ENSDARP00000148501; ENSDARG00000062646
GeneIDi103283056

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
200424
ZFINiZDB-GENE-060526-109, tet3

Phylogenomic databases

GeneTreeiENSGT00940000157631

Gene expression databases

ExpressionAtlasiA0A2R8Q5Y7, baseline

Family and domain databases

InterProiView protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3
PANTHERiPTHR23358, PTHR23358, 2 hits
PfamiView protein in Pfam
PF12851, Tet_JBP, 1 hit
SMARTiView protein in SMART
SM01333, Tet_JBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R8Q5Y7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R8Q5Y7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: April 7, 2021
This is version 15 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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