UniProtKB - A0A2R8Q462 (A0A2R8Q462_DANRE)
Protein
Submitted name:
IQ motif and Sec7 domain ArfGEF 2a
Gene
iqsec2a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: InterPro
GO - Biological processi
- regulation of ARF protein signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: IQ motif and Sec7 domain ArfGEF 2aImported |
Gene namesi | Name:iqsec2aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-170302-3, iqsec2a |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 452 – 645 | SEC7InterPro annotationAdd BLAST | 194 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 200 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 272 – 300 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 314 – 452 | DisorderedSequence analysisAdd BLAST | 139 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 192 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 335 – 355 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 363 – 380 | Pro-richSequence analysisAdd BLAST | 18 | |
Compositional biasi | 381 – 427 | PolarSequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the BRAG family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000159667 |
Family and domain databases
CDDi | cd00171, Sec7, 1 hit |
Gene3Di | 1.10.1000.11, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR033742, IQSEC_PH IPR011993, PH-like_dom_sf IPR023394, Sec7_C_sf IPR000904, Sec7_dom IPR035999, Sec7_dom_sf |
Pfami | View protein in Pfam PF16453, IQ_SEC7_PH, 1 hit PF01369, Sec7, 1 hit |
SMARTi | View protein in SMART SM00222, Sec7, 1 hit |
SUPFAMi | SSF48425, SSF48425, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS50190, SEC7, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
A0A2R8Q462-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
NNAKTTNLHF LVNYRCPNSV FSTLCVFVVF SVEGDPQCPD TTSFSDSTCS
60 70 80 90 100
QGPYLGNSEP SLAWAQRSRH QPASLALRKQ EEEESKRCKA LSDSYELSTD
110 120 130 140 150
LQDKKVEMLE RKYGGYFLSR RAARTIQTAF RQYRMNKNFQ RLRSSASESR
160 170 180 190 200
MTRRIILSNM HWQQQGRYTS HHTSGTAGQT GSTNTQQETD SPAHCPSDRE
210 220 230 240 250
EYSHVTSLAD SMDDTLTCHV DFGECVWSNK PTSREQERLG DSTATSYSDV
260 270 280 290 300
TLYMDDGMPC SPLSIERVPS STDTEYWGVS SGVGGREDRG STNSRRSTPC
310 320 330 340 350
TECRDFRLRG SHLPVLTIEP PSDSSVDMSD RSDRGSLSRQ LLYEQEPTAG
360 370 380 390 400
GSPQGTLKHN PAPRMPNPYP TSPSPTQPPL TPLSSSSSAP LPASGMEQSD
410 420 430 440 450
GDNDSLNSTT NSNETINCSS GSSSRDSLRE PLPPLGKQTY QRESRHSWDS
460 470 480 490 500
PAFNNDVVQR RHYRIGLNLF NKKPEKGIQY LIERGFVSDT PVGIARFILE
510 520 530 540 550
RKGLSRQMIG EFLGNRQKQF NKDVLDCVLD EMDFSGMDLD DALRKFQAQI
560 570 580 590 600
KVQGEAQKVE RLVEAFSQRY CVCNPALVRQ FQNPDTIFIL AFAIILLNTD
610 620 630 640 650
MYSPNVKAER KMKLEDFIKN LRGVDNGQDI PRDLLVGIYQ RIQKWELRTN
660 670 680 690 700
DDHVSQVQAV ERVIVGKKPV TVIFRFIVCV CVMVITTPNV TKIFQKKKTS
710 720 730 740 750
VTYSFRQSFP LVEMQVHMFQ NSYYAHGIRL TSAMPGAERK VLIVFNAPSQ
760 770 780 790 800
QDRTRFTSDL RESIAEVQDM EKYRVESELE KQKGVMRPGS VGGMKTEAVN
810 820 830 840 850
GTLGRPSLDD TYAAGEGLKR TALSSSLRDL SDTGTTHIHT RKLHTISTTA
LRFCEEYS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8QGT6 | A0A2R8QGT6_DANRE | IQ motif and Sec7 domain ArfGEF 2a | iqsec2a | 1,013 | Annotation score: | ||
A0A0G2L9N5 | A0A0G2L9N5_DANRE | IQ motif and Sec7 domain ArfGEF 2a | iqsec2a | 1,629 | Annotation score: | ||
A0A2R8Q8B1 | A0A2R8Q8B1_DANRE | IQ motif and Sec7 domain ArfGEF 2a | iqsec2a | 1,487 | Annotation score: | ||
A0A2R8Q8W8 | A0A2R8Q8W8_DANRE | IQ motif and Sec7 domain ArfGEF 2a | iqsec2a | 1,492 | Annotation score: | ||
A0A2R8QUT2 | A0A2R8QUT2_DANRE | IQ motif and Sec7 domain ArfGEF 2a | iqsec2a | 1,281 | Annotation score: | ||
A0A2R8QNV2 | A0A2R8QNV2_DANRE | IQ motif and Sec7 domain ArfGEF 2a | iqsec2a | 825 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928736 Genomic DNA No translation available. CR388083 Genomic DNA No translation available. CT025733 Genomic DNA No translation available. CT583651 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000180755; ENSDARP00000149810; ENSDARG00000102125 ENSDART00000193227; ENSDARP00000147553; ENSDARG00000112951 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928736 Genomic DNA No translation available. CR388083 Genomic DNA No translation available. CT025733 Genomic DNA No translation available. CT583651 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000180755; ENSDARP00000149810; ENSDARG00000102125 ENSDART00000193227; ENSDARP00000147553; ENSDARG00000112951 |
Organism-specific databases
ZFINi | ZDB-GENE-170302-3, iqsec2a |
Phylogenomic databases
GeneTreei | ENSGT00940000159667 |
Family and domain databases
CDDi | cd00171, Sec7, 1 hit |
Gene3Di | 1.10.1000.11, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR033742, IQSEC_PH IPR011993, PH-like_dom_sf IPR023394, Sec7_C_sf IPR000904, Sec7_dom IPR035999, Sec7_dom_sf |
Pfami | View protein in Pfam PF16453, IQ_SEC7_PH, 1 hit PF01369, Sec7, 1 hit |
SMARTi | View protein in SMART SM00222, Sec7, 1 hit |
SUPFAMi | SSF48425, SSF48425, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS50190, SEC7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R8Q462_DANRE | |
Accessioni | A0A2R8Q462Primary (citable) accession number: A0A2R8Q462 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | April 7, 2021 | |
This is version 21 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |