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UniProtKB - A0A2R8Q097 (A0A2R8Q097_DANRE)

Entry version 19 (19 Jan 2022)
Sequence version 1 (20 Jun 2018)
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Protein
Submitted name:

Eukaryotic translation elongation factor 1 beta 2

Gene

zdbf2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-156842, Eukaryotic Translation Elongation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Eukaryotic translation elongation factor 1 beta 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:zdbf2Imported
Synonyms:eef1b2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-7310, eef1b2
ZDB-GENE-101101-1, zdbf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A2R8Q097, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 85DBF4-typeInterPro annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 39DisorderedSequence analysisAdd BLAST39
Regioni169 – 261DisorderedSequence analysisAdd BLAST93
Regioni548 – 570DisorderedSequence analysisAdd BLAST23
Regioni605 – 632DisorderedSequence analysisAdd BLAST28
Regioni649 – 732DisorderedSequence analysisAdd BLAST84
Regioni782 – 905DisorderedSequence analysisAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 27Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi190 – 218Polar residuesSequence analysisAdd BLAST29
Compositional biasi237 – 255Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi548 – 569Polar residuesSequence analysisAdd BLAST22
Compositional biasi655 – 697Polar residuesSequence analysisAdd BLAST43
Compositional biasi705 – 732Polar residuesSequence analysisAdd BLAST28
Compositional biasi828 – 905Polar residuesSequence analysisAdd BLAST78

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183014

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		6.10.250.3410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038890, ZDBF2
IPR006572, Znf_DBF
IPR038545, Znf_DBF_sf

The PANTHER Classification System

More...PANTHERi		PTHR21639, PTHR21639, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07535, zf-DBF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51265, ZF_DBF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2R8Q097-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLGEGPKPS AKNAERRPTD ISGRTRREEP VAGPSSYQRQ GYCSCCQVLY 
        60         70         80         90        100
NSVEQHILSA QHREVVRASR ANVSSGSLLE RFLQDVLQHH PHHYSDTRPS 
       110        120        130        140        150
HADLPLLTTP LVPKEVLSEV YCGSDDDGVS VGTREEMPTS DEESCQMLQV 
       160        170        180        190        200
ATAGPAVTTD FTANTHLQTA SQKGKMVPEQ PPPEKYSPTQ GFLHRTSGSS 
       210        220        230        240        250
ANDKLHTSQF TLPVQRESSH THPSRHPPSE GAPVSKTGAV EHRKAHKKTN 
       260        270        280        290        300
RENEGSDTIK ASCAPPAAKC ITSKDQPETF RSVTEESTKW ISALPPWKGL 
       310        320        330        340        350
HREQTFSNLS DQIRDVIEEV IEKYCYGLNV DQQEEDGSFL FGPQSVSDSK 
       360        370        380        390        400
GSEEWDNAIQ VALGKTKGEE KNLAQLLEVH IDLEDQTYQT QLDTALNTVG 
       410        420        430        440        450
TPEEPKQNAE DNVIPDLPHI PQSFVGKTWT QVMFEDDIKI DSIVREFQQG 
       460        470        480        490        500
QFRCYFDSES LAMYGKHCKK RRKNKKRDNK EQTETVELNP TDILPLIEHN 
       510        520        530        540        550
EEDPKHSAVL VRKTRQKYYR QASRCQVVKV SHGTQTIPLS CPMVRSKPTQ 
       560        570        580        590        600
ETFPSTYNDE PQQCPSPERT PEMKTRLCAL KLPTSYCKIM SPLQPKTVVY 
       610        620        630        640        650
VLSSPDGGQG ISKPTPIKKA GRKRKSCDSD GGLKYKYKKT PLKFYDPLTN 
       660        670        680        690        700
RILKSPPKGM SSPPNSKSLS HVRQLFRSLS PDINKERQGQ SPGSSRKGRG 
       710        720        730        740        750
RRNMVDLCTT TSDSILESGG PSEPSSSLTS SRRAIFTRSS ISSRSCLLLG 
       760        770        780        790        800
HLTPSAHVDD SSKAHSHSCA GSSYKVGGME QEEHIQQTSV DQTPIRRSLR 
       810        820        830        840        850
RAGLLTPAKR PSAPPYRTKR KSAKQQRKVK SQGSLQRSVS SHISAECRTS 
       860        870        880        890        900
PRNKSPGRAS LRSSASSNLA IQPVITSSSK QINTMLSASQ QKRGRGRTAT 

VHTAD
Length:905
Mass (Da):100,324
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C53E2D0D077700F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6IQE2Q6IQE2_DANRE
Elongation factor 1-beta
eef1b2
225Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CT009620 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001313402.1, NM_001326473.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000185321; ENSDARP00000145801; ENSDARG00000044521

Database of genes from NCBI RefSeq genomes

More...GeneIDi		563160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:563160

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009620 Genomic DNA No translation available.
RefSeqiNP_001313402.1, NM_001326473.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSDART00000185321; ENSDARP00000145801; ENSDARG00000044521
GeneIDi563160
KEGGidre:563160

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57683
ZFINiZDB-GENE-030131-7310, eef1b2
ZDB-GENE-101101-1, zdbf2

Phylogenomic databases

GeneTreeiENSGT00950000183014

Enzyme and pathway databases

ReactomeiR-DRE-156842, Eukaryotic Translation Elongation

Gene expression databases

ExpressionAtlasiA0A2R8Q097, baseline and differential

Family and domain databases

Gene3Di6.10.250.3410, 1 hit
InterProiView protein in InterPro
IPR038890, ZDBF2
IPR006572, Znf_DBF
IPR038545, Znf_DBF_sf
PANTHERiPTHR21639, PTHR21639, 2 hits
PfamiView protein in Pfam
PF07535, zf-DBF, 1 hit
PROSITEiView protein in PROSITE
PS51265, ZF_DBF4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R8Q097_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R8Q097
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: January 19, 2022
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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