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UniProtKB - A0A2R8M2H8 (A0A2R8M2H8_CALJA)

Entry version 16 (19 Jan 2022)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

SORBS2

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SORBS2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9483 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix › Callithrix
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008225 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini491 – 552SoHoInterPro annotationAdd BLAST62
Domaini810 – 869SH3InterPro annotationAdd BLAST60
Domaini885 – 946SH3InterPro annotationAdd BLAST62
Domaini988 – 1047SH3InterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 55DisorderedSequence analysisAdd BLAST28
Regioni267 – 319DisorderedSequence analysisAdd BLAST53
Regioni343 – 398DisorderedSequence analysisAdd BLAST56
Regioni560 – 815DisorderedSequence analysisAdd BLAST256
Regioni949 – 975DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi345 – 398Polar residuesSequence analysisAdd BLAST54
Compositional biasi560 – 588Polar residuesSequence analysisAdd BLAST29
Compositional biasi592 – 607Pro residuesSequence analysisAdd BLAST16
Compositional biasi608 – 638Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi653 – 667Pro residuesSequence analysisAdd BLAST15
Compositional biasi685 – 699Pro residuesSequence analysisAdd BLAST15
Compositional biasi705 – 727Polar residuesSequence analysisAdd BLAST23
Compositional biasi755 – 779Polar residuesSequence analysisAdd BLAST25
Compositional biasi798 – 815Basic and acidic residuesSequence analysisAdd BLAST18

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157056

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3

The PANTHER Classification System

More...PANTHERi		PTHR14167:SF56, PTHR14167:SF56, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

A0A2R8M2H8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAWRSYHGN QEALNGDATY SSLAAKGFRS VRPNLQDKRS PTQAPPPPDR 
        60         70         80         90        100
KESLHSSLIT GHTKGVILDQ SGTNTQIPSC TEYLANKKPP QGTMYSNEDS 
       110        120        130        140        150
RQTIVYSEES NTTVSYTQKI TNPLPAASST DPPPFTDIQE DYRQDSQTRR 
       160        170        180        190        200
ISTLKLTHNQ DLGSSSPMNT PQFSKSVQVP SFLQRSCSLP PHPVPETHTA 
       210        220        230        240        250
SLSIQIAPLS GQDPESHQRL PELPPETAKI PLQQERQKSA VAAASQSSDC 
       260        270        280        290        300
RVLGNQNLPA SVWEVNASQT HRQTTPEASP PCPPSVVPLN RATFSPGSVA 
       310        320        330        340        350
SSAPLSLPPP DGLGSSRLHT PQSLSHCLYK HLLPAPEGLI RSHDAGSLTT 
       360        370        380        390        400
DSSLAEHSSR SESESSTAML EELQIGDSDT TGRSETPSPT WGQRSAVTDG 
       410        420        430        440        450
TTLTTPAAIH SQITVNGNSG GAVSPMSYYQ RPFSPSAYSL PASLNSSIVM 
       460        470        480        490        500
QHGTSLDSAE TYPQHAQSLD GTSSSSIPLY RSSEEEKRVT VIKAPHYPGI 
       510        520        530        540        550
GPVDESGIPT AIRTTVDRPK DWYKTMFKQI HMVHKPDDDT DMYNTPYAYN 
       560        570        580        590        600
AGLYNPPYSA QSHPAAKTQT YRPLSKSHSD NSTHAFKDAS SPVPPPHVPP 
       610        620        630        640        650
PVPPLRPRDR SSTEKHDWDP PDRKVDTRKF RSEPRSIFEY EPGKSSILQH 
       660        670        680        690        700
ERPPPLPTTP TPVPREPGLK PLSSSGGGVA ASPSPPPRSG APTPSARAPA 
       710        720        730        740        750
LPPTRASLYQ SSIDRSLERP MSSASSASDF RKRRKSEPAV GPPRGLGDQR 
       760        770        780        790        800
TSPGRADLPG SSTTLTKSFT SSSPSSPSRA KDRESPRSYS STLTDMGRSG 
       810        820        830        840        850
PRERRGTPEK EKLPAKAVYD FKAQTSKELS FKKGDTVYIL RKIDQNWYEG 
       860        870        880        890        900
EHHGRVGIFP ISYVEKLTPP EKAQPARPPP PAQPGEIGEA IAKYNFSADT 
       910        920        930        940        950
NVELSLRKGD RVILLKRVDQ NWYEGKIPGA NRQGIFPVSY VEVVKKNTKG 
       960        970        980        990       1000
AEDYPDPPMP HSYSSDRIHS LSSNKPQRPV FTHENIQGGG EPFQALYNYT 
      1010       1020       1030       1040 
PRNEDELELR ESDVIDVMEK CDDGWFVGTS RRTKFFGTFP GNYVKRL
Length:1,047
Mass (Da):114,471
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D25E289328F3FAD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7I6I2F7I6I2_CALJA
Uncharacterized protein
SORBS2
1,198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7GKY5F7GKY5_CALJA
Uncharacterized protein
SORBS2
1,067Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7I2V0F7I2V0_CALJA
Uncharacterized protein
SORBS2
1,594Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7I2V2F7I2V2_CALJA
Uncharacterized protein
SORBS2
1,048Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7I493F7I493_CALJA
Uncharacterized protein
SORBS2
1,157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8MSR5A0A2R8MSR5_CALJA
Uncharacterized protein
SORBS2
1,523Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VTE5F6VTE5_CALJA
Uncharacterized protein
SORBS2
1,015Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7EGI9F7EGI9_CALJA
Uncharacterized protein
SORBS2
1,579Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7I4K1F7I4K1_CALJA
Uncharacterized protein
SORBS2
815Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSCJAT00000084105; ENSCJAP00000052669; ENSCJAG00000006015

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSCJAT00000084105; ENSCJAP00000052669; ENSCJAG00000006015

Phylogenomic databases

GeneTreeiENSGT00940000157056

Family and domain databases

InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
PANTHERiPTHR14167:SF56, PTHR14167:SF56, 1 hit
PfamiView protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit
SUPFAMiSSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R8M2H8_CALJA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R8M2H8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: December 11, 2019
Last modified: January 19, 2022
This is version 16 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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