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Entry version 6 (11 Dec 2019)
Sequence version 1 (20 Jun 2018)
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Protein

Reverse transcriptase domain-containing protein

Gene

OFAS_OFAS013975

Organism
Oncopeltus fasciatus (Large milkweed bug)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reverse transcriptase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:OFAS_OFAS013975Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOncopeltus fasciatus (Large milkweed bug)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7536 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraHeteropteraPanheteropteraPentatomomorphaLygaeoideaLygaeidaeLygaeinaeOncopeltus

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini704 – 902Reverse transcriptaseInterPro annotationAdd BLAST199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041588 Integrase_H2C2
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom
IPR041577 RT_RNaseH_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17921 Integrase_H2C2, 1 hit
PF17919 RT_RNaseH_2, 1 hit
PF00078 RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A2R7WSP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPLEISENK ASDNVLYELL VYKEWELDKE KQAFCLLIKF CSSEKQQISV
60 70 80 90 100
DCLRLLINRS YSEASALKLV TSYLGLFSDD KFCPHHGYLT FCPALYVLEN
110 120 130 140 150
PITPTSLEQK TNLLQDREIA YENTVKNHIY NKQLIDKKRK HHNFKEGDFV
160 170 180 190 200
YVDHASKMNR NKLEEIRIGP LKIIKKISNS IFELDTGHRK KEVCIKVEQN
210 220 230 240 250
PNDSKASHHC LKWIQPQEDD TVIFEFPPQY QLLNANHKDL LQIPIVRNVL
260 270 280 290 300
KSLSKHGSYR IVSMTLPAET VPLYFDGKGN VVFEEYFLQE KDYRTWRSNI
310 320 330 340 350
SPHPQTSSDA PSAAVLDILH KLSTRAEEPQ RAINSKRLNL TKVKSDFVLD
360 370 380 390 400
NFDGRNSEVG RWLDTFIREC ERCQVNDSKN KVLILRLFME GIAKNWYSST
410 420 430 440 450
LIELGLEKDF TDWELKMRTE FKEQGWKKIR EAYNYRYIGG HYDDYVLRKQ
460 470 480 490 500
SLLLEQEHAI DKIIQLNLIV MGLPVNVQEK LDRSKIDSIA ELLGELRRIE
510 520 530 540 550
PSLLSLQKKS ANIVTQNKKP ILRIQDNNMT FRTIGGRHGF AGCVNVKLRV
560 570 580 590 600
MNLEKDVQMF IVNDENFKYD VLLGLDLIVS FYLNLNCKLH LYQTLPEEHK
610 620 630 640 650
KDNVENFIQK LDGLRDVYVN YNEGIDVNIF EAKVDHLDST KRREIENLIN
660 670 680 690 700
KFNCIFAKDK FDVGRVNDHE AHIQLFEHKF VSRKPYRCSI PDQQEIESQI
710 720 730 740 750
SQLLKADLIE ESTSPFASPV TLAYKREENK KNRLCIDFRE LNRLVVPEPQ
760 770 780 790 800
PFPLIEELIT KTRGCRWFTA LDINSAFWSI PIRIKDRYIT AFVTQDGHWQ
810 820 830 840 850
WKCLPFGLKT SPQIFQRVLN SILRRNNLKD FSVCYMDDIL IFSKTFTDHC
860 870 880 890 900
NFAKNEVKYL GHILSENTVR PLGGDNLMAI QNFPIPTRKT KKNVRQFLGK
910 920 930 940 950
VNFYHKYIPN SSTLLEPLHN LLRKNTDLKW TDQCQRSFEE LKKHLCSQPI
960 970 980 990 1000
LAIFDPKLKI IIETDASGEG VGAVLKQLQE DSTMKPVAYL KKKTEGLSEK
1010 1020 1030 1040 1050
KESYLLRMPS NERSNTILAA LTFQIITDHK PLENLKINTR SDEELGDMLL
1060 1070 1080 1090 1100
FLSQFNFQVT YPPGKRNMEA DSLSRNPVLE ESDYSEELIK TVNFLSISDI
1110 1120 1130 1140 1150
TLDQTQHAAE IEKFRQIKRE GGIFYKISDT NKRIVISQEL TDVLIAKIHK
1160 1170 1180 1190 1200
EYGHIGSSHV INEFRKFYYT QNLDSRVKTY CQNCEICIKN KSQTPCTYGF
1210 1220 1230 1240 1250
LSKLGPARAP FKIVSLDTIG GKETIHQNDH FTRYAFISTS KNQTANDFVK
1260 1270 1280 1290 1300
LLKKVQDKHA IQTLLTDQYS GTNSAEFKNF LKKEKINLIF TSVNNPASNG
1310 1320 1330 1340 1350
LNQTLSEIIG KIMAAAFLLP WQIAVSPNGK LVAILQDSVL ELRQSKDEYT

TVVGRAS
Length:1,357
Mass (Da):157,131
Last modified:June 20, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88CD580832BAC9AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1357Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KK855443 Genomic DNA Translation: PTY22588.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KK855443 Genomic DNA Translation: PTY22588.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR041588 Integrase_H2C2
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom
IPR041577 RT_RNaseH_2
PfamiView protein in Pfam
PF17921 Integrase_H2C2, 1 hit
PF17919 RT_RNaseH_2, 1 hit
PF00078 RVT_1, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2R7WSP7_ONCFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2R7WSP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 20, 2018
Last sequence update: June 20, 2018
Last modified: December 11, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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