UniProtKB - A0A2R4IQJ4 (A0A2R4IQJ4_MYCTX)
Protein
DNA gyrase subunit B
Gene
gyrB
Organism
Mycobacterium tuberculosis
Status
Functioni
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.UniRule annotation
Miscellaneous
Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.UniRule annotation
Catalytic activityi
- ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationARBA annotation EC:5.6.2.2
Cofactori
Mg2+ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: InterPro
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- DNA-dependent DNA replication Source: UniProtKB-UniRule
- DNA topological change Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase, TopoisomeraseUniRule annotationARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gyrBUniRule annotationImported ORF Names:AYJ03_000025Imported, DSI38_08120Imported, E5M52_15230Imported, E5M78_15120Imported, FRD82_14680Imported |
Organismi | Mycobacterium tuberculosisImported |
Taxonomic identifieri | 1773 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- chromosome Source: InterPro
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 453 – 567 | ToprimInterPro annotationAdd BLAST | 115 |
Sequence similaritiesi
Belongs to the type II topoisomerase GyrB family.ARBA annotation
Belongs to the type II topoisomerase family.UniRule annotation
Family and domain databases
CDDi | cd03366, TOPRIM_TopoIIA_GyrB, 1 hit |
Gene3Di | 3.30.230.10, 1 hit 3.30.565.10, 1 hit 3.40.50.670, 1 hit |
HAMAPi | MF_01898, GyrB, 1 hit |
InterProi | View protein in InterPro IPR002288, DNA_gyrase_B_C IPR011557, GyrB IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR001241, Topo_IIA IPR013760, Topo_IIA-like_dom_sf IPR013759, Topo_IIA_B_C IPR013506, Topo_IIA_bsu_dom2 IPR018522, TopoIIA_CS IPR006171, TOPRIM_domain IPR034160, TOPRIM_GyrB |
Pfami | View protein in Pfam PF00204, DNA_gyraseB, 1 hit PF00986, DNA_gyraseB_C, 1 hit PF02518, HATPase_c, 1 hit PF01751, Toprim, 1 hit |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit SM00433, TOP2c, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit SSF56719, SSF56719, 1 hit |
TIGRFAMsi | TIGR01059, gyrB, 1 hit |
PROSITEi | View protein in PROSITE PS00177, TOPOISOMERASE_II, 1 hit PS50880, TOPRIM, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A2R4IQJ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQKKKAQD EYGAASITIL EGLEAVRKRP GMYIGSTGER GLHHLIWEVV
60 70 80 90 100
DNAVDEAMAG YATTVNVVLL EDGGVEVADD GRGIPVATHA SGIPTVDVVM
110 120 130 140 150
TQLHAGGKFD SDAYAISGGL HGVGVSVVNA LSTRLEVEIK RDGYEWSQVY
160 170 180 190 200
EKSEPLGLKQ GAPTKKTGST VRFWADPAVF ETTEYDFETV ARRLQEMAFL
210 220 230 240 250
NKGLTINLTD ERVTQDEVVD EVVSDVAEAP KSASERAAES TAPHKVKSRT
260 270 280 290 300
FHYPGGLVDF VKHINRTKNA IHSSIVDFSG KGTGHEVEIA MQWNAGYSES
310 320 330 340 350
VHTFANTINT HEGGTHEEGF RSALTSVVNK YAKDRKLLKD KDPNLTGDDI
360 370 380 390 400
REGLAAVISV KVSEPQFEGQ TKTKLGNTEV KSFVQKVCNE QLTHWFEANP
410 420 430 440 450
TDAKVVVNKA VSSAQARIAA RKARELVRRK SATDIGGLPG KLADCRSTDP
460 470 480 490 500
RKSELYVVEG DSAGGSAKSG RDSMFQAILP LRGKIINVEK ARIDRVLKNT
510 520 530 540 550
EVQAIITALG TGIHDEFDIG KLRYHKIVLM ADADVDGQHI STLLLTLLFR
560 570 580 590 600
FMRPLIENGH VFLAQPPLYK LKWQRSDPEF AYSDRERDGL LEAGLKAGKK
610 620 630 640 650
INKEDGIQRY KGLGEMDAKE LWETTMDPSV RVLRQVTLDD AAAADELFSI
660 670
LMGEDVDARR SFITRNAKDV RFLDV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | MG995341 Genomic DNA Translation: AVV29662.1 MG995342 Genomic DNA Translation: AVV29663.1 MG995343 Genomic DNA Translation: AVV29664.1 MG995344 Genomic DNA Translation: AVV29665.1 MG995345 Genomic DNA Translation: AVV29666.1 MG995346 Genomic DNA Translation: AVV29667.1 MG995347 Genomic DNA Translation: AVV29668.1 MG995349 Genomic DNA Translation: AVV29670.1 MG995350 Genomic DNA Translation: AVV29671.1 MG995351 Genomic DNA Translation: AVV29672.1 MG995352 Genomic DNA Translation: AVV29673.1 MG995353 Genomic DNA Translation: AVV29674.1 MG995354 Genomic DNA Translation: AVV29675.1 MG995355 Genomic DNA Translation: AVV29676.1 MG995356 Genomic DNA Translation: AVV29677.1 MG995358 Genomic DNA Translation: AVV29679.1 MG995359 Genomic DNA Translation: AVV29680.1 MG995360 Genomic DNA Translation: AVV29681.1 MG995361 Genomic DNA Translation: AVV29682.1 MG995362 Genomic DNA Translation: AVV29683.1 MG995363 Genomic DNA Translation: AVV29684.1 MG995364 Genomic DNA Translation: AVV29685.1 MG995365 Genomic DNA Translation: AVV29686.1 MG995377 Genomic DNA Translation: AVV29698.1 MG995378 Genomic DNA Translation: AVV29699.1 MG995379 Genomic DNA Translation: AVV29700.1 MG995380 Genomic DNA Translation: AVV29701.1 MG995381 Genomic DNA Translation: AVV29702.1 MG995382 Genomic DNA Translation: AVV29703.1 MG995383 Genomic DNA Translation: AVV29704.1 MG995384 Genomic DNA Translation: AVV29705.1 MG995385 Genomic DNA Translation: AVV29706.1 MG995386 Genomic DNA Translation: AVV29707.1 MG995389 Genomic DNA Translation: AVV29710.1 MG995390 Genomic DNA Translation: AVV29711.1 MG995391 Genomic DNA Translation: AVV29712.1 MG995392 Genomic DNA Translation: AVV29713.1 MG995393 Genomic DNA Translation: AVV29714.1 MG995394 Genomic DNA Translation: AVV29715.1 MG995395 Genomic DNA Translation: AVV29716.1 MG995396 Genomic DNA Translation: AVV29717.1 MG995397 Genomic DNA Translation: AVV29718.1 MG995398 Genomic DNA Translation: AVV29719.1 MG995399 Genomic DNA Translation: AVV29720.1 MG995400 Genomic DNA Translation: AVV29721.1 MG995401 Genomic DNA Translation: AVV29722.1 MG995402 Genomic DNA Translation: AVV29723.1 MG995403 Genomic DNA Translation: AVV29724.1 MG995404 Genomic DNA Translation: AVV29725.1 MG995405 Genomic DNA Translation: AVV29726.1 MG995406 Genomic DNA Translation: AVV29727.1 MG995408 Genomic DNA Translation: AVV29729.1 MG995409 Genomic DNA Translation: AVV29730.1 MG995410 Genomic DNA Translation: AVV29731.1 MG995411 Genomic DNA Translation: AVV29732.1 MG995412 Genomic DNA Translation: AVV29733.1 MG995414 Genomic DNA Translation: AVV29735.1 MG995415 Genomic DNA Translation: AVV29736.1 CP046529 Genomic DNA Translation: QGV19780.1 QSXJ01000556 Genomic DNA Translation: REM68059.1 SRLJ01000036 Genomic DNA Translation: TGD73717.1 SRLK01000036 Genomic DNA Translation: TGD90200.1 VOOQ01000466 Genomic DNA Translation: TXB92648.1 |
RefSeqi | WP_003917863.1, NZ_WUJD01000001.1 |
Genome annotation databases
GeneIDi | 45423962 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | MG995341 Genomic DNA Translation: AVV29662.1 MG995342 Genomic DNA Translation: AVV29663.1 MG995343 Genomic DNA Translation: AVV29664.1 MG995344 Genomic DNA Translation: AVV29665.1 MG995345 Genomic DNA Translation: AVV29666.1 MG995346 Genomic DNA Translation: AVV29667.1 MG995347 Genomic DNA Translation: AVV29668.1 MG995349 Genomic DNA Translation: AVV29670.1 MG995350 Genomic DNA Translation: AVV29671.1 MG995351 Genomic DNA Translation: AVV29672.1 MG995352 Genomic DNA Translation: AVV29673.1 MG995353 Genomic DNA Translation: AVV29674.1 MG995354 Genomic DNA Translation: AVV29675.1 MG995355 Genomic DNA Translation: AVV29676.1 MG995356 Genomic DNA Translation: AVV29677.1 MG995358 Genomic DNA Translation: AVV29679.1 MG995359 Genomic DNA Translation: AVV29680.1 MG995360 Genomic DNA Translation: AVV29681.1 MG995361 Genomic DNA Translation: AVV29682.1 MG995362 Genomic DNA Translation: AVV29683.1 MG995363 Genomic DNA Translation: AVV29684.1 MG995364 Genomic DNA Translation: AVV29685.1 MG995365 Genomic DNA Translation: AVV29686.1 MG995377 Genomic DNA Translation: AVV29698.1 MG995378 Genomic DNA Translation: AVV29699.1 MG995379 Genomic DNA Translation: AVV29700.1 MG995380 Genomic DNA Translation: AVV29701.1 MG995381 Genomic DNA Translation: AVV29702.1 MG995382 Genomic DNA Translation: AVV29703.1 MG995383 Genomic DNA Translation: AVV29704.1 MG995384 Genomic DNA Translation: AVV29705.1 MG995385 Genomic DNA Translation: AVV29706.1 MG995386 Genomic DNA Translation: AVV29707.1 MG995389 Genomic DNA Translation: AVV29710.1 MG995390 Genomic DNA Translation: AVV29711.1 MG995391 Genomic DNA Translation: AVV29712.1 MG995392 Genomic DNA Translation: AVV29713.1 MG995393 Genomic DNA Translation: AVV29714.1 MG995394 Genomic DNA Translation: AVV29715.1 MG995395 Genomic DNA Translation: AVV29716.1 MG995396 Genomic DNA Translation: AVV29717.1 MG995397 Genomic DNA Translation: AVV29718.1 MG995398 Genomic DNA Translation: AVV29719.1 MG995399 Genomic DNA Translation: AVV29720.1 MG995400 Genomic DNA Translation: AVV29721.1 MG995401 Genomic DNA Translation: AVV29722.1 MG995402 Genomic DNA Translation: AVV29723.1 MG995403 Genomic DNA Translation: AVV29724.1 MG995404 Genomic DNA Translation: AVV29725.1 MG995405 Genomic DNA Translation: AVV29726.1 MG995406 Genomic DNA Translation: AVV29727.1 MG995408 Genomic DNA Translation: AVV29729.1 MG995409 Genomic DNA Translation: AVV29730.1 MG995410 Genomic DNA Translation: AVV29731.1 MG995411 Genomic DNA Translation: AVV29732.1 MG995412 Genomic DNA Translation: AVV29733.1 MG995414 Genomic DNA Translation: AVV29735.1 MG995415 Genomic DNA Translation: AVV29736.1 CP046529 Genomic DNA Translation: QGV19780.1 QSXJ01000556 Genomic DNA Translation: REM68059.1 SRLJ01000036 Genomic DNA Translation: TGD73717.1 SRLK01000036 Genomic DNA Translation: TGD90200.1 VOOQ01000466 Genomic DNA Translation: TXB92648.1 |
RefSeqi | WP_003917863.1, NZ_WUJD01000001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 45423962 |
Family and domain databases
CDDi | cd03366, TOPRIM_TopoIIA_GyrB, 1 hit |
Gene3Di | 3.30.230.10, 1 hit 3.30.565.10, 1 hit 3.40.50.670, 1 hit |
HAMAPi | MF_01898, GyrB, 1 hit |
InterProi | View protein in InterPro IPR002288, DNA_gyrase_B_C IPR011557, GyrB IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr IPR001241, Topo_IIA IPR013760, Topo_IIA-like_dom_sf IPR013759, Topo_IIA_B_C IPR013506, Topo_IIA_bsu_dom2 IPR018522, TopoIIA_CS IPR006171, TOPRIM_domain IPR034160, TOPRIM_GyrB |
Pfami | View protein in Pfam PF00204, DNA_gyraseB, 1 hit PF00986, DNA_gyraseB_C, 1 hit PF02518, HATPase_c, 1 hit PF01751, Toprim, 1 hit |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit SM00433, TOP2c, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit SSF56719, SSF56719, 1 hit |
TIGRFAMsi | TIGR01059, gyrB, 1 hit |
PROSITEi | View protein in PROSITE PS00177, TOPOISOMERASE_II, 1 hit PS50880, TOPRIM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2R4IQJ4_MYCTX | |
Accessioni | A0A2R4IQJ4Primary (citable) accession number: A0A2R4IQJ4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 20, 2018 |
Last sequence update: | June 20, 2018 | |
Last modified: | February 10, 2021 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |