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Entry version 10 (07 Oct 2020)
Sequence version 1 (25 Apr 2018)
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Protein
Submitted name:

Putative polyprotein

Gene
N/A
Organism
Anopheles darlingi (Mosquito)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative polyproteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles darlingi (Mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri43151 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    NucleusARBA annotation

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 61PHD-typeInterPro annotationAdd BLAST52
    Domaini1432 – 1621Integrase catalyticInterPro annotationAdd BLAST190
    Domaini1616 – 1695FHAInterPro annotationAdd BLAST80

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2414 – 2447DisorderedSequence analysisAdd BLAST34

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2414 – 2430PolarSequence analysisAdd BLAST17

    Keywords - Domaini

    Zinc-fingerPROSITE-ProRule annotation

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.40.10, 1 hit
    3.30.420.10, 2 hits
    3.30.70.270, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR043502, DNA/RNA_pol_sf
    IPR005312, DUF1759
    IPR040676, DUF5641
    IPR000253, FHA_dom
    IPR001584, Integrase_cat-core
    IPR008042, Retrotrans_Pao
    IPR043128, Rev_trsase/Diguanyl_cyclase
    IPR012337, RNaseH-like_sf
    IPR036397, RNaseH_sf
    IPR000477, RT_dom
    IPR019786, Zinc_finger_PHD-type_CS
    IPR011011, Znf_FYVE_PHD
    IPR001965, Znf_PHD
    IPR019787, Znf_PHD-finger
    IPR013083, Znf_RING/FYVE/PHD

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03564, DUF1759, 1 hit
    PF18701, DUF5641, 1 hit
    PF05380, Peptidase_A17, 1 hit
    PF00628, PHD, 1 hit
    PF00078, RVT_1, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00249, PHD, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53098, SSF53098, 1 hit
    SSF56672, SSF56672, 1 hit
    SSF57903, SSF57903, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50006, FHA_DOMAIN, 1 hit
    PS50994, INTEGRASE, 1 hit
    PS01359, ZF_PHD_1, 1 hit
    PS50016, ZF_PHD_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A2M4CVY8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSYKFVINTV GNCRLCQNPD DEIAKMIDCS ECDRLFHLVC VKLTRKPTRE
    60 70 80 90 100
    EHWLCTKCQK ISYELNRLKD LAQKKVSKED EEKDTSMFET LLERLVLGQQ
    110 120 130 140 150
    QQARDQTQEL AKIVQTITKG NGEPSPIEIL LKRQALTQLP KFGGSAKDWP
    160 170 180 190 200
    NFKKTFDETS REGAFSDIEN LNRLKQVLHG TALKGVQQLM MEAENVPEIL
    210 220 230 240 250
    KRLGETFGRP DLVYMELLND LYKIRKDSRT VIIDMTNALE NIVKNVHLMD
    260 270 280 290 300
    KPAYLNDHRL VMELTAKLPH PIQVKRAEYM TQLESSLDIQ TLDNLCEWLK
    310 320 330 340 350
    PFAKTALMLS TITINNHKGT VNFHEKSTEY KPKKSNHEKA KPRLCLLCNK
    360 370 380 390 400
    SHETIKCYAF VKQTPSERLT TVLSKNVCYG CLASNQHRIQ GCKEAKQCGI
    410 420 430 440 450
    NGCKGKHHKM LHVYNKTQNI QINKTQINSL RDDNPQIQDD EKAPVLNHQE
    460 470 480 490 500
    VMKTSAIHYQ ILPVKLINGR MSFETYAFLD PGSSLTLLEE NVARRLKLNG
    510 520 530 540 550
    TKLPMTLQWT QGKSSTHSES QQVQLVIKGS TKTGYKLKDV RTVKNLILPI
    560 570 580 590 600
    QWFNYQEISE KYSYLKNLPI SSFNNVQPTI MIGINHNHLL MGLEHKYGRL
    610 620 630 640 650
    GEPIAMKTRL GWLIYGKLPN NDWINHSMII QEDNTLRDLM VKHFSVEDFG
    660 670 680 690 700
    VKPVTNLPES ENDKRAKAIL KNTLKYKDGR YEVGLLWKND NHQFSWSIDN
    710 720 730 740 750
    AMSRLINLES KLNKDPELKK WAIETFDSYV EKGYARKLEP WEIIKYVPQT
    760 770 780 790 800
    FYLPHFIVIN KNKVPLKPRL VFDAAAKIKG QSLNDALLSG PDATTSLFGI
    810 820 830 840 850
    LIKFREEKYA ICGDIKEMFH QVKIRKEDQE AQRFVWRNCE NRHPDHYVMQ
    860 870 880 890 900
    VMTFGSTCSP SCAQAAKNEN AERLKKKYPL AYSPIINQHY VDDYNDSFSC
    910 920 930 940 950
    IEKAKTVIEQ VIKAHDEGGF FITKFCSNSK KLLLSLPKER VDPEKMKLLE
    960 970 980 990 1000
    DKQEDSSKIL GIYWNTTNDN IAFRATLEKL PTEVFSNLRP PTKREVLSYI
    1010 1020 1030 1040 1050
    MSIFDPLGLI SHVTIHGKIL MQEIHKESNE WDKPISKRVL QMWMSWLNKI
    1060 1070 1080 1090 1100
    KLTNNIRIPR WILTEDSSKK NLELHVFVDA SEKAFAAVIY IKSNIENEAH
    1110 1120 1130 1140 1150
    VQILASKTRV APIKTMSIPR LELQAALLGV RLWLAVTNEL RLKISNSTFW
    1160 1170 1180 1190 1200
    SDSKTVLAWI NSTHRKYKQF VAHRIGEILD STAIDQWRWV PSAENPADEA
    1210 1220 1230 1240 1250
    TKEITKPSIW LTGPNFLKLP ERQWPEMEPN ETTEEASFVN LHSNEDFIQE
    1260 1270 1280 1290 1300
    HKFSDWWKLV KRMCLIIKII DFGLKRKVSH IYLMGERIRA ENILYRKAQM
    1310 1320 1330 1340 1350
    DAYQDEIADL KNNGSLTTIG PLSKLTPILD ENGVMRFKSR LEFAENLPIA
    1360 1370 1380 1390 1400
    TRVPIILPNM HHITHLIIRW YHEKYNHQSD KVVLAALQQK YHIIKLNVAF
    1410 1420 1430 1440 1450
    RYVKTRCQYC KNAKAKPLTP MMAPLPECRT NSFVFPFTHT GIDYFGPFDV
    1460 1470 1480 1490 1500
    IVRRSTEKRW GVIFTCMTTR AAHIELAEKL DTSSFFVCFM NFQARRGAVS
    1510 1520 1530 1540 1550
    HVYSDNGTNF VGANNELLKI VKQINSKMET GEAIKLNIEW HFNPPKAPHF
    1560 1570 1580 1590 1600
    GGAWERLIRI IKNNLQDMIY CKKNHIPTLE VLRCALIQVE FILNSRPLTN
    1610 1620 1630 1640 1650
    IPLNGEGDEP LTPFHILIGR AGSCSLPFEF EAQEITRAHW KLALHYKKYF
    1660 1670 1680 1690 1700
    WSRWLLEYLP LIATRPKWNN ETEPLKIDDI VLITDNGTWL KGRVVEVFTG
    1710 1720 1730 1740 1750
    KDGQVRRALV KVQNKTYKRT TDKLAVLDVH NKPNIQHTSV KEDTPKDTSK
    1760 1770 1780 1790 1800
    VEESKNFVTF HTNSQQEQVS KPKTLKKRKK GSILPCAWAK EELQAKTKHV
    1810 1820 1830 1840 1850
    TATKRRAEPL KLTMHDDIVH KGASKVMRLN SWALVLMTLL FFIGQTCGFS
    1860 1870 1880 1890 1900
    INGLIAYDCA NNEINITSYS LMSVAPCIPS TKNITTVESR IQVLQRSPKI
    1910 1920 1930 1940 1950
    FVHVYQCRVI IKRSIKHCGA FSHTSDYENS YAYIVKEFTP TECRLAQTSG
    1960 1970 1980 1990 2000
    EISLTIEHKI RELKRNHTVR GQTLIIGSLL GPNCVGGVYK TPLYTWENAL
    2010 2020 2030 2040 2050
    VYYEYEIDLH DYTTTADVES NQIILRNGIV CTYGLGWCLD SEIGYITWDI
    2060 2070 2080 2090 2100
    NVGRQCEELD YEVIYEGTVN KTFDSDKVND RLNAVYTVLN DKQMFSIRAR
    2110 2120 2130 2140 2150
    NSAQICGFDS YETDHPRIFI LEANGYQSPF KRRVSHGKNY DLFTYFNSKI
    2160 2170 2180 2190 2200
    TLVENFLGQR LNDIYAAVMT EMCKIDKALM ETKLTLARLN PSEFVSNLVK
    2210 2220 2230 2240 2250
    RSGYTAVVAA EVLYILECKP VFVTYEPKED CYQEVPVKYN DRSMFMAPVT
    2260 2270 2280 2290 2300
    RMLQLRGTQI ECTQLLPAKF MIGGRWYTTD QKLRETTAPQ QLTTDIITSW
    2310 2320 2330 2340 2350
    SYTSLPNLMQ SGVYDAESLQ GFKFDALVSE KIIDNALQKY WSKLLSWSTW
    2360 2370 2380 2390 2400
    LGNITSTAIG LYIICRTIKF TIDTIIHGKI LYDIYGLGWQ LIAAFWDSLT
    2410 2420 2430 2440
    NLLSHRKHMQ QRSSNEILSQ GDNDDSAASP VQFRKNPIYP PLNATDN
    Length:2,447
    Mass (Da):281,943
    Last modified:April 25, 2018 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AD2002AE368CBB2
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    GGFL01005193 Transcribed RNA Translation: MBW69371.1

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    GGFL01005193 Transcribed RNA Translation: MBW69371.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Family and domain databases

    Gene3Di3.30.40.10, 1 hit
    3.30.420.10, 2 hits
    3.30.70.270, 1 hit
    InterProiView protein in InterPro
    IPR043502, DNA/RNA_pol_sf
    IPR005312, DUF1759
    IPR040676, DUF5641
    IPR000253, FHA_dom
    IPR001584, Integrase_cat-core
    IPR008042, Retrotrans_Pao
    IPR043128, Rev_trsase/Diguanyl_cyclase
    IPR012337, RNaseH-like_sf
    IPR036397, RNaseH_sf
    IPR000477, RT_dom
    IPR019786, Zinc_finger_PHD-type_CS
    IPR011011, Znf_FYVE_PHD
    IPR001965, Znf_PHD
    IPR019787, Znf_PHD-finger
    IPR013083, Znf_RING/FYVE/PHD
    PfamiView protein in Pfam
    PF03564, DUF1759, 1 hit
    PF18701, DUF5641, 1 hit
    PF05380, Peptidase_A17, 1 hit
    PF00628, PHD, 1 hit
    PF00078, RVT_1, 1 hit
    SMARTiView protein in SMART
    SM00249, PHD, 1 hit
    SUPFAMiSSF53098, SSF53098, 1 hit
    SSF56672, SSF56672, 1 hit
    SSF57903, SSF57903, 1 hit
    PROSITEiView protein in PROSITE
    PS50006, FHA_DOMAIN, 1 hit
    PS50994, INTEGRASE, 1 hit
    PS01359, ZF_PHD_1, 1 hit
    PS50016, ZF_PHD_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2M4CVY8_ANODA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2M4CVY8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 25, 2018
    Last sequence update: April 25, 2018
    Last modified: October 7, 2020
    This is version 10 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Transposable elementARBA annotation
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