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Protein

UvrABC system protein B

Gene

uvrB

Organism
Spiroplasma clarkii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 48ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotationSAAS annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotationImported
ORF Names:SCLAR_v1c13190Imported
OrganismiSpiroplasma clarkiiImported
Taxonomic identifieri2139 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesSpiroplasmataceaeSpiroplasma
Proteomesi
  • UP000231179 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 202Helicase ATP-bindingInterPro annotationAdd BLAST175
Domaini440 – 595Helicase C-terminalInterPro annotationAdd BLAST156
Domaini624 – 659UVRInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili604 – 640Sequence analysisAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi94 – 117Beta-hairpinUniRule annotationAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_00204 UvrB, 1 hit
InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004807 UvrB
IPR024759 UvrB_YAD/RRR_dom
PANTHERiPTHR24029 PTHR24029, 1 hit
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF02151 UVR, 1 hit
PF12344 UvrB, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00631 uvrb, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K8KIX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEYKEFELV SNFTPSGDQP QAIVKLLQGL TAGVKHQVLL GATGTGKTFT
60 70 80 90 100
MANIVKSINK PTLVLAHNKT LAMQLYIELK ELFPNNRVEY YVSNFDFFQP
110 120 130 140 150
EAYLPARDLY IDKDARINRD LDMMRLSALN ALTTRNDVIV VASVAAIYAT
160 170 180 190 200
RNPDEYSQIF FELNVGQKIS KKELLSFLVQ TGYTRNDTAT EMGTFATKGD
210 220 230 240 250
VIKISPSWTD EYNLRISMFG DEIEALDIVD VLNNTVKEKL RLFTIFPASA
260 270 280 290 300
YVTDMDLIKK VVKNIEVELD LRVKELLDEG KMIEADRLEK RTRYDMETLS
310 320 330 340 350
EFGICAGIEN YSAHLDFRAP GVAPYSLLDF FGKDFLTIID ESHMMIPQVR
360 370 380 390 400
GMYNTDLSRK ETLVKHGFRL PSALDNRPLN FEEFSNRLDQ VIYTSATPGD
410 420 430 440 450
YELELTNHEV AEQIIRPTGL LDPVIDILPT HNQMEVIIEN IHQIVKKSQK
460 470 480 490 500
VFITAITIKQ SEDITSFLQE RNIKVAYLHS ELKTLERNQI LLDLRRGVYD
510 520 530 540 550
VIVGVNLLRE GIDIPEVSLV CILEADKQGF LRNARSLIQT VGRAARNAEG
560 570 580 590 600
RVIFFADTIS KAMEEAIEET NRRRSKQEAY NVTNNITPKT IIKKISDFGL
610 620 630 640 650
NATLKNKVAE LAKGKKKIKL TEKEKLIEEL RVEMLTAAKE QNYEKAAELR

DLIIEVSAE
Length:659
Mass (Da):74,960
Last modified:April 25, 2018 - v1
Checksum:iCDDC26EF2B7F787D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP024870 Genomic DNA Translation: ATX71617.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP024870 Genomic DNA Translation: ATX71617.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_00204 UvrB, 1 hit
InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004807 UvrB
IPR024759 UvrB_YAD/RRR_dom
PANTHERiPTHR24029 PTHR24029, 1 hit
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF02151 UVR, 1 hit
PF12344 UvrB, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00631 uvrb, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50151 UVR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K8KIX0_9MOLU
AccessioniPrimary (citable) accession number: A0A2K8KIX0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 25, 2018
Last sequence update: April 25, 2018
Last modified: November 7, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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