Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionine aminopeptidase

Gene

METAP1D

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161SubstrateUniRule annotation1
Metal bindingi178Divalent metal cation 1UniRule annotation1
Metal bindingi189Divalent metal cation 1UniRule annotation1
Metal bindingi189Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi252Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei259SubstrateUniRule annotation1
Metal bindingi284Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi315Divalent metal cation 1UniRule annotation1
Metal bindingi315Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, Protease
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidaseUniRule annotation (EC:3.4.11.18UniRule annotation)
Gene namesi
Name:METAP1DImported
OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)Imported
Taxonomic identifieri39432 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri
Proteomesi
  • UP000233220 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 321Peptidase_M24InterPro annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000002284
KOiK01265

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A2K6U745-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPTGVHLL VRRGSQRIFS SPLNHIYLHK QSSSQQRRNF FFRRQRDISH
60 70 80 90 100
SIVLPAAVSS AHPVPKHIKK PDYVTTGIVP DWGDSIEVKN EDQIQGLRQA
110 120 130 140 150
CQLARHVLLL AGKSLKVDMT TEEIDALVHQ EIISHNAYPS PLGYGGFPKS
160 170 180 190 200
VCTSVNNVLC HGIPDSRPLQ DGDIINIDVT VYYNGYHGDT SETFLVGNVD
210 220 230 240 250
ECGKKLVEVA RRCRDEAIAA CRAGAPFSVI GNTISCITHQ NGLQVCPYFV
260 270 280 290 300
GHGIGSYFHG HPEIWHHAND NDLPMEEGMA FTIEPIITEG SPEFKVLEDA
310 320 330
WTAVSLDNQR SAQFEHTVLI TSRGAQILTK LPHEA
Length:335
Mass (Da):37,041
Last modified:March 28, 2018 - v1
Checksum:i1BDAA07D20A74E00
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6U740A0A2K6U740_SAIBB
Methionyl aminopeptidase type 1D, m...
METAP1D
146Annotation score:

Sequence databases

RefSeqiXP_010350391.1, XM_010352089.1

Genome annotation databases

EnsembliENSSBOT00000044596; ENSSBOP00000027718; ENSSBOG00000030256
GeneIDi101038279
KEGGisbq:101038279

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_010350391.1, XM_010352089.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSBOT00000044596; ENSSBOP00000027718; ENSSBOG00000030256
GeneIDi101038279
KEGGisbq:101038279

Organism-specific databases

CTDi254042

Phylogenomic databases

GeneTreeiENSGT00390000002284
KOiK01265

Family and domain databases

CDDicd01086 MetAP1, 1 hit
HAMAPiMF_01974 MetAP_1, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002467 Pept_M24A_MAP1
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF55920 SSF55920, 1 hit
TIGRFAMsiTIGR00500 met_pdase_I, 1 hit
PROSITEiView protein in PROSITE
PS00680 MAP_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6U745_SAIBB
AccessioniPrimary (citable) accession number: A0A2K6U745
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: September 12, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again