HIF1A

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
E-box binding Source: Ensembl
histone acetyltransferase binding Source: Ensembl
histone deacetylase binding Source: Ensembl
Hsp90 protein binding Source: Ensembl
nuclear hormone receptor binding Source: Ensembl
p53 binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
axonal transport of mitochondrion Source: Ensembl
B-1 B cell homeostasis Source: Ensembl
cardiac ventricle morphogenesis Source: Ensembl
cartilage development Source: Ensembl
cellular iron ion homeostasis Source: Ensembl
cellular response to interleukin-1 Source: Ensembl
cellular response to virus Source: Ensembl
cerebral cortex development Source: Ensembl
collagen metabolic process Source: Ensembl
connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
cytokine production involved in inflammatory response Source: Ensembl
digestive tract morphogenesis Source: Ensembl
dopaminergic neuron differentiation Source: Ensembl
elastin metabolic process Source: Ensembl
embryonic hemopoiesis Source: Ensembl
embryonic placenta development Source: Ensembl
epithelial cell differentiation involved in mammary gland alveolus development Source: Ensembl
epithelial to mesenchymal transition Source: Ensembl
glucose homeostasis Source: Ensembl
heart looping Source: Ensembl
hemoglobin biosynthetic process Source: Ensembl
hypoxia-inducible factor-1alpha signaling pathway Source: Ensembl
intestinal epithelial cell maturation Source: Ensembl
iris morphogenesis Source: Ensembl
lactate metabolic process Source: Ensembl
lactation Source: Ensembl
muscle cell cellular homeostasis Source: Ensembl
negative regulation of bone mineralization Source: Ensembl
negative regulation of gene expression Source: Ensembl
negative regulation of growth Source: Ensembl
negative regulation of mesenchymal cell apoptotic process Source: Ensembl
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Source: Ensembl
negative regulation of reactive oxygen species metabolic process Source: Ensembl
negative regulation of thymocyte apoptotic process Source: Ensembl
negative regulation of TOR signaling Source: Ensembl
neural crest cell migration Source: Ensembl
neural fold elevation formation Source: Ensembl
outflow tract morphogenesis Source: Ensembl
oxygen homeostasis Source: Ensembl
positive regulation of angiogenesis Source: Ensembl
positive regulation of autophagy of mitochondrion Source: Ensembl
positive regulation of blood vessel endothelial cell migration Source: Ensembl
positive regulation of erythrocyte differentiation Source: Ensembl
positive regulation of hormone biosynthetic process Source: Ensembl
positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
positive regulation of macroautophagy Source: Ensembl
positive regulation of neuroblast proliferation Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
positive regulation of signaling receptor activity Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Ensembl
positive regulation of vascular endothelial growth factor production Source: Ensembl
positive regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
regulation of aerobic respiration Source: Ensembl
regulation of catalytic activity Source: Ensembl
regulation of glycolytic process Source: Ensembl
regulation of protein neddylation Source: Ensembl
regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: Ensembl
regulation of transforming growth factor beta2 production Source: Ensembl
response to iron ion Source: Ensembl
response to muscle activity Source: Ensembl
response to reactive oxygen species Source: Ensembl
retina vasculature development in camera-type eye Source: Ensembl
vascular endothelial growth factor production Source: Ensembl
visual learning Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	ActivatorARBA annotation

Molecular function

ActivatorARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hypoxia-inducible factor 1-alphaARBA annotation
Gene namesⁱ	Name:HIF1AImported
Organismⁱ	Saimiri boliviensis boliviensis (Bolivian squirrel monkey)Imported
Taxonomic identifierⁱ	39432 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Platyrrhini › Cebidae › Saimiriinae › Saimiri › Saimiri boliviensis
Proteomesⁱ	UP000233220 Componentⁱ: Unplaced

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	402	4-hydroxyprolineUniRule annotation	1
Modified residueⁱ	564	4-hydroxyprolineUniRule annotation	1
Modified residueⁱ	803	(3S)-3-hydroxyasparagineUniRule annotation	1

Keywords - PTMⁱ

HydroxylationARBA annotation, Ubl conjugationARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

histone acetyltransferase binding Source: Ensembl
histone deacetylase binding Source: Ensembl
Hsp90 protein binding Source: Ensembl
nuclear hormone receptor binding Source: Ensembl
p53 binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	17 – 70	BHLHInterPro annotationAdd BLAST	54
Domainⁱ	93 – 148	PASInterPro annotationAdd BLAST	56
Domainⁱ	247 – 298	PASInterPro annotationAdd BLAST	52

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 30	DisorderedSequence analysisAdd BLAST	30
Regionⁱ	492 – 520	DisorderedSequence analysisAdd BLAST	29
Regionⁱ	646 – 688	DisorderedSequence analysisAdd BLAST	43

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	492 – 516	PolarSequence analysisAdd BLAST		25
Compositional biasⁱ	646 – 670	PolarSequence analysisAdd BLAST		25

Keywords - Domainⁱ

RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156774
Database of Orthologous Groups More...OrthoDBⁱ	547545at2759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083, HLH, 1 hit cd00130, PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598, bHLH_dom IPR001321, HIF-1_alpha IPR014887, HIF-1_TAD_C IPR021537, HIF_alpha_subunit IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11413, HIF-1, 1 hit PF08778, HIF-1a_CTAD, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit
PRINTSⁱ	PR01080, HYPOXIAIF1A
SMARTⁱ	View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits
SUPFAMⁱ	SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229, sensory_box, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

A0A2K6U1D8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGASGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV 
        60         70         80         90        100
SSHLDKASVM RLTISYLRVR KLLDAGDLDI EDEMKAQMNC FYLKALDGFV 
       110        120        130        140        150
MVLTDDGDMI YISDNVNKYM GLTQFELTGH SVFDFTHPCD HEEMREMLTH 
       160        170        180        190        200
RNGPVKKGKE QNTQRSFFLR MKCTLTSRGR TMNIKSATWK VLHCTGHIHV 
       210        220        230        240        250
YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK TFLSRHSLDM 
       260        270        280        290        300
KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 
       310        320        330        340        350
TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL 
       360        370        380        390        400
IFSLQQTECV LKPVESSDMK MTQLFTKVES EDTSSLFDKL KKEPDALTLL 
       410        420        430        440        450
APAAGDTIIS LDFGSNDTET DDQQLEEVPL YNDVMLPSSN EKLQNINLSM 
       460        470        480        490        500
SPLATSETTK PLRSSADPAL NQEVALKLEP NPESLELSFT MPQIQDQPPS 
       510        520        530        540        550
PSDGSTRQSS PEPNSPSEYC FYVDSDMVNE FKLELVEKLF AEDTEAKNPF 
       560        570        580        590        600
STQDTDLDLE MLAPYIPMDD DFQLRSFDQL SPLESSSASP ESASPQSTVT 
       610        620        630        640        650
VFQQTQIQEL TANATTTTAT TDELKTVTKD RMEDIKILIA SPSPTHIHKE 
       660        670        680        690        700
TTSATSSPYR DTQSRTASPN RAGKGVIEQT EKSHPRSPNV LSVALSQRTT 
       710        720        730        740        750
VPEEELNPKI LALQNAQRKR KIEHDGSLFQ AVGIGTLLQQ PDDHATTTSL 
       760        770        780        790        800
SWKRVKGCKS SEQNGMEQKT IILIPSDLAC RLLGQSMDES GLPQLTSYDC 
       810        820 
EVNAPIQGSR NLLQGEELLR ALDQVN

Length:826

Mass (Da):92,722

Last modified:March 28, 2018 - v1

Checksum:ⁱ42BF9D7D506D9DAE

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2K6U1F9	A0A2K6U1F9_SAIBB	Hypoxia-inducible factor 1-alpha Hypoxia-inducible factor 1-alpha	HIF1A	816	Annotation score:
A0A2K6U1L6	A0A2K6U1L6_SAIBB	Hypoxia-inducible factor 1-alpha Hypoxia-inducible factor 1-alpha	HIF1A	810	Annotation score:
A0A2K6U1J2	A0A2K6U1J2_SAIBB	Hypoxia-inducible factor 1-alpha Hypoxia-inducible factor 1-alpha	HIF1A	735	Annotation score:

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_003924457.1, XM_003924408.2

RefSeqⁱ

XP_003924457.1, XM_003924408.2

Genome annotation databases

Ensemblⁱ	ENSSBOT00000042602; ENSSBOP00000025733; ENSSBOG00000029024
GeneIDⁱ	101044689
KEGGⁱ	sbq:101044689

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A2K6U1D8	Hypoxia-inducible factor 1-alpha	)	HUMAN		826	UniRef90_Q16665
Hypoxia-inducible factor 1-alpha		BOSMU		823
Hypoxia-inducible factor 1-alpha		BOVIN		823
Hypoxia-inducible factor 1-alpha		EOSFB		819
Hypoxia-inducible factor 1-alpha		PANPA		826
+293

Protein	Similar proteins		Species	Score	Length	Source
A0A2K6U1D8	Hypoxia-inducible factor 1-alpha	)	HUMAN		826	UniRef50_Q16665
Hypoxia-inducible factor 1-alpha		BOVIN		823
Hypoxia-inducible factor 1-alpha		BOSMU		823
Hypoxia-inducible factor 1-alpha		EOSFB		819
Hypoxia-inducible factor 1-alpha		PANPA		826
+429

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_003924457.1, XM_003924408.2

RefSeqⁱ

XP_003924457.1, XM_003924408.2

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSSBOT00000042602; ENSSBOP00000025733; ENSSBOG00000029024
GeneIDⁱ	101044689
KEGGⁱ	sbq:101044689

Organism-specific databases

CTDⁱ	3091

CTDⁱ

3091

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000156774
OrthoDBⁱ	547545at2759

Family and domain databases

CDDⁱ	cd00083, HLH, 1 hit cd00130, PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598, bHLH_dom IPR001321, HIF-1_alpha IPR014887, HIF-1_TAD_C IPR021537, HIF_alpha_subunit IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3
Pfamⁱ	View protein in Pfam PF11413, HIF-1, 1 hit PF08778, HIF-1a_CTAD, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit
PRINTSⁱ	PR01080, HYPOXIAIF1A
SMARTⁱ	View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits
SUPFAMⁱ	SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229, sensory_box, 2 hits
PROSITEⁱ	View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A2K6U1D8_SAIBB
Accessionⁱ	A0A2K6U1D8Primary (citable) accession number: A0A2K6U1D8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 28, 2018
	Last sequence update:	March 28, 2018
	Last modified:	February 10, 2021
	This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A2K6U1D8 (A0A2K6U1D8_SAIBB)

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Hypoxia-inducible factor 1-alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ