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Protein

Homeobox protein

Gene

PITX2

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi93 – 152HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox proteinUniRule annotation
Gene namesi
Name:PITX2Imported
OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)Imported
Taxonomic identifieri39432 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri
Proteomesi
  • UP000233220 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 151HomeoboxInterPro annotationAdd BLAST61
Domaini287 – 300OARInterPro annotationAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi287 – 300OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family. Bicoid subfamily.UniRule annotation

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00930000150861

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6TME7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCMKGPLHL EHRAAGTKLS AVSSSSSCHY PQPLAMASVL APGQPRSLDS
60 70 80 90 100
SKHRLEVHTI SDTSSPEAAE KDKSQQGKNE DVGAEDPSKK KRQRRQRTHF
110 120 130 140 150
TSQQLQELEA TFQRNRYPDM STREEIAVWT NLTEARVRVW FKNRRAKWRK
160 170 180 190 200
RERNQQAELC KNGFGPQFNG LMQPYDDMYP GYSYNNWAAK GLTSASLSTK
210 220 230 240 250
SFPFFNSMNV NPLSSQSMFS PPNSISSMSM SSSMVPSAVT GVPGSSLNSL
260 270 280 290 300
NNLNNLSSPS LNSAVPTPAC PYAPPTPPYV YRDTCNSSLA SLRLKAKQHS
310 320
SFGYASVQNP ASNLSACQYA VDRPV
Length:325
Mass (Da):35,909
Last modified:March 28, 2018 - v1
Checksum:iB9C87393C256EB9A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6TMG6A0A2K6TMG6_SAIBB
Homeobox protein
PITX2
271Annotation score:
A0A2K6TME4A0A2K6TME4_SAIBB
Homeobox protein
PITX2
317Annotation score:
A0A2K6TMK4A0A2K6TMK4_SAIBB
Homeobox protein
PITX2
266Annotation score:
A0A2K6TME9A0A2K6TME9_SAIBB
Paired like homeodomain 2
PITX2
174Annotation score:

Sequence databases

RefSeqiXP_003929503.1, XM_003929454.2

Genome annotation databases

EnsembliENSSBOT00000037670; ENSSBOP00000020836; ENSSBOG00000026969
GeneIDi101042994

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_003929503.1, XM_003929454.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSBOT00000037670; ENSSBOP00000020836; ENSSBOG00000026969
GeneIDi101042994

Organism-specific databases

CTDi5308

Phylogenomic databases

GeneTreeiENSGT00930000150861

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6TME7_SAIBB
AccessioniPrimary (citable) accession number: A0A2K6TME7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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