DHX36

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
DNA helicase activity Source: Ensembl
double-stranded RNA binding Source: Ensembl
G-quadruplex DNA binding Source: Ensembl
G-quadruplex RNA binding Source: Ensembl
histone deacetylase binding Source: Ensembl
magnesium ion binding Source: Ensembl
mRNA 3'-UTR AU-rich region binding Source: Ensembl
mRNA 5'-UTR binding Source: Ensembl
RNA helicase activity Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
single-stranded DNA binding Source: Ensembl
telomerase RNA binding Source: Ensembl

GO - Biological processⁱ

3'-UTR-mediated mRNA destabilization Source: Ensembl
cellular response to arsenite ion Source: Ensembl
cellular response to heat Source: Ensembl
cellular response to UV Source: Ensembl
G-quadruplex DNA unwinding Source: Ensembl
ossification Source: Ensembl
positive regulation of cardioblast differentiation Source: Ensembl
positive regulation of cytoplasmic translation Source: Ensembl
positive regulation of hematopoietic progenitor cell differentiation Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of interferon-alpha secretion Source: Ensembl
positive regulation of mRNA 3'-end processing Source: Ensembl
positive regulation of myeloid dendritic cell cytokine production Source: Ensembl
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: Ensembl
positive regulation of telomere maintenance via telomere lengthening Source: Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
regulation of embryonic development Source: Ensembl
regulation of transcription by RNA polymerase III Source: Ensembl
regulation of transcription from RNA polymerase II promoter involved in spermatogenesis Source: Ensembl
response to exogenous dsRNA Source: Ensembl
response to virus Source: Ensembl
RNA secondary structure unwinding Source: Ensembl
telomerase RNA stabilization Source: Ensembl

Keywordsⁱ

Molecular function	HydrolaseSAAS annotation
Ligand	ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: DEAH-box helicase 36Imported
Gene namesⁱ	Name:DHX36Imported
Organismⁱ	Saimiri boliviensis boliviensis (Bolivian squirrel monkey)Imported
Taxonomic identifierⁱ	39432 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Platyrrhini › Cebidae › Saimiriinae › Saimiri › Saimiri boliviensis
Proteomesⁱ	UP000233220 Componentⁱ: Whole Genome Shotgun Assembly

Subcellular locationⁱ

GO - Cellular component

Interactionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	220 – 390	Helicase ATP-bindingInterPro annotationAdd BLAST		171
Domainⁱ	480 – 650	Helicase C-terminalInterPro annotationAdd BLAST		171

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 64	DisorderedSequence analysisAdd BLAST		64

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156903
KEGG Orthology (KO) More...KOⁱ	K14442
OMAⁱ	TMVFPMA
Database of Orthologous Groups More...OrthoDBⁱ	278674at2759

Family and domain databases

InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR002464 DNA/RNA_helicase_DEAH_CS IPR011709 DUF1605 IPR007502 Helicase-assoc_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF04408 HA2, 1 hit PF00271 Helicase_C, 1 hit PF07717 OB_NTP_bind, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00847 HA2, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

A0A2K6T8G7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSYDYHQNWG RDGGSRSAGG GYGGGSTGGH RGSRGSGGGG GGGGGGGGGR 
        60         70         80         90        100
GGRDRHPGHL KGREIGLWYA RKQGQKNKEA ERQERAVVHM DERREEQIVQ 
       110        120        130        140        150
LLNSVQAKND KQSEAQISWF APEDHGYGAE VSTKNTPRSE KKLDNQETKL 
       160        170        180        190        200
INQEKKVFRI RNKSYIDRDS EYLLQENEPD GTLDQQLLED LQKKKNDLRY 
       210        220        230        240        250
IEMQHFREKL PSYGMQKELV NLIDNHQVTV ISGETGCGKT TQVTQFILDN 
       260        270        280        290        300
YIERGKGSAC RIVCTQPRRI SAISVAERVA AERAESCGNG NSTGYQIRLQ 
       310        320        330        340        350
SRLPRKQGSI LYCTTGIILQ WLQSDPHLSS VSHIILDEIH ERNLQSDVLM 
       360        370        380        390        400
TVVKDLLNFR SDLKVILMSA TLNAEKFSEY FGNCPMIHIP GFTFPVVEYL 
       410        420        430        440        450
LEDIIEKIRY VPEQKEQRSQ FKRGFMQGHV NRQEKEEKDA IYKERWPDYV 
       460        470        480        490        500
RELRRRYSSS TVDVIEMMDD DKVDLNLIVA LIRYIVLEEE DGAILVFLPG 
       510        520        530        540        550
WDNISTLHDL LMSQVMFKSD KFLIIPLHSL MPTVNQTQVF KRTPPGVRKI 
       560        570        580        590        600
VIATNIAETS ITIDDVVYVI DGGKIKETHF DTQNNISTMS AEWVSQANAK 
       610        620        630        640        650
QRKGRAGRVQ PGHCYHLYNG LRASLLDDYQ LPEILRTPLE ELCLQIKILR 
       660        670        680        690        700
LGGIAYFLSR LMDPPSNEAV LLSIRHLMEL NALDKQEELT PLGVHLARLP 
       710        720        730        740        750
VEPHIGKMIL FGALFCCLDP VLTIAASLSF KDPFVIPLGK EKIADARRKE 
       760        770        780        790        800
LAKDTRSDHL TVVNAFKGWE EARRRGFRYE KDYCWEYFLS SNTLQMLHNM 
       810        820        830        840        850
KGQFAEHLLG AGFVSSRNPK DPESNINSDN EKIIKAVICA GLYPKVAKIR 
       860        870        880        890        900
LNLGKKRKMV KVYTKTDGLV SVHPKSVNVE QTDFHYNWLI YHLKMRTSSI 
       910        920        930        940        950
YLYDCTEISP YCLLFFGGDI SIQKDNDQET IAVDEWIIFQ SPARIAHLVK 
       960        970        980        990       1000
ELRKELDILL QEKIESPHPV DWNDTKSRDC AVLSAIIDLI KTQEKATPRN 
      1010 
FPPRFQDGYY S

Length:1,011

Mass (Da):115,066

Last modified:March 28, 2018 - v1

Checksum:ⁱ0A202CF663C9A41A

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2K6T8J0	A0A2K6T8J0_SAIBB	DEAH-box helicase 36 DEAH-box helicase 36	DHX36	982	Annotation score:
A0A2K6T8I7	A0A2K6T8I7_SAIBB	DEAH-box helicase 36 DEAH-box helicase 36	DHX36	153	Annotation score:

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_003925063.1, XM_003925014.2

RefSeqⁱ

XP_003925063.1, XM_003925014.2

Genome annotation databases

Ensemblⁱ	ENSSBOT00000032735; ENSSBOP00000015932; ENSSBOG00000024666
GeneIDⁱ	101047864
KEGGⁱ	sbq:101047864

Protein	Similar proteins		Species	Score	Length	Source
A0A2K6T8G7	DEAH-box helicase 36		SAIBB		153	UniRef100_A0A2K6T8G7

Protein	Similar proteins		Species	Score	Length	Source
A0A2K6T8G7	ATP-dependent DNA/RNA helicase DHX36	)	HUMAN		1008	UniRef90_Q9H2U1
DEAH-box helicase 36		SAIBB		153
Uncharacterized protein		CERAT		1011
Macaca fascicularis brain cDNA clone: QorA-14054, similar to human DEAH (Asp-Glu-Ala-His) box polypeptide 36 (DHX36), mRNA, RefSeq: NM_020865.1		MACFA		153
Uncharacterized protein		CALJA		1010
+39

Protein	Similar proteins		Species	Score	Length	Source
A0A2K6T8G7	ATP-dependent DNA/RNA helicase DHX36	)	HUMAN		1008	UniRef50_Q9H2U1
ATP-dependent DNA/RNA helicase DHX36	)	BOVIN		1010
ATP-dependent DNA/RNA helicase DHX36		MOUSE		1001
ATP-dependent DNA/RNA helicase DHX36		RAT		1000
Uncharacterized protein		CERAT		1011
+601

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_003925063.1, XM_003925014.2

RefSeqⁱ

XP_003925063.1, XM_003925014.2

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSSBOT00000032735; ENSSBOP00000015932; ENSSBOG00000024666
GeneIDⁱ	101047864
KEGGⁱ	sbq:101047864

Organism-specific databases

CTDⁱ	170506

CTDⁱ

170506

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000156903
KOⁱ	K14442
OMAⁱ	TMVFPMA
OrthoDBⁱ	278674at2759

Family and domain databases

InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR002464 DNA/RNA_helicase_DEAH_CS IPR011709 DUF1605 IPR007502 Helicase-assoc_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF04408 HA2, 1 hit PF00271 Helicase_C, 1 hit PF07717 OB_NTP_bind, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00847 HA2, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A2K6T8G7_SAIBB
Accessionⁱ	A0A2K6T8G7Primary (citable) accession number: A0A2K6T8G7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 28, 2018
	Last sequence update:	March 28, 2018
	Last modified:	October 16, 2019
	This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - A0A2K6T8G7 (A0A2K6T8G7_SAIBB)

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DEAH-box helicase 36

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Cytosol

Nucleus

Other locations

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Sequence (1+)ⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A2K6T8G7 (A0A2K6T8G7_SAIBB)

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DEAH-box helicase 36

DHX36

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ