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Protein

Tubulin alpha chain

Gene

TUBA8

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
Name:TUBA8Imported
OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)Imported
Taxonomic identifieri39432 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri
Proteomesi
  • UP000233220 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 180TubulinInterPro annotationAdd BLAST180
Domaini182 – 327Tubulin_CInterPro annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili352 – 372Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00920000149044
KOiK07374

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2K6SLR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLEPTVVD EVRAGTYRQL FHPEQLITGK EDAANNYARG HYTVGKESID
60 70 80 90 100
LVLDRIRKLT DACSGLQGFL IFHSFGGGTG SGFTSLLMER LSLDYGKKSK
110 120 130 140 150
LEFAIYPAPQ VSTAVVEPYN SILTTHTTLE HSDCAFMVDN EAIYDICHRS
160 170 180 190 200
LDIERPTYTN LNRLISQIVS SITASLRFDG ALNVDLTEFQ TNLVPYPRIH
210 220 230 240 250
FPLVTYAPII SAEKAYHEQL SVAEITSSCF EPNSQMVKCD PRHGKYMACC
260 270 280 290 300
MLYRGDVVPK DVNVAIAAIK TKRTIQFVDW CPTGFKVGIN YQPPTVVPGG
310 320 330 340 350
DLAKVQRAVC MLSNTTAIAE AWARLDHKFD LMYAKRAFVH WYVGEGMEEG
360 370 380
EFSEAREDLA ALEKDYEEVG TDSFEEENEG EEF
Length:383
Mass (Da):42,908
Last modified:March 28, 2018 - v1
Checksum:i97A7046135ED38A5
GO

Sequence databases

RefSeqiXP_003942741.1, XM_003942692.2

Genome annotation databases

EnsembliENSSBOT00000025089; ENSSBOP00000008330; ENSSBOG00000021079
GeneIDi101039362
KEGGisbq:101039362

Similar proteinsi

Entry informationi

Entry nameiA0A2K6SLR4_SAIBB
AccessioniPrimary (citable) accession number: A0A2K6SLR4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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