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UniProtKB - A0A2K6S4G8 (A0A2K6S4G8_SAIBB)

Entry version 15 (10 Feb 2021)
Sequence version 1 (28 Mar 2018)
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Protein

DNA mismatch repair protein

Gene

MSH6

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the post-replicative DNA mismatch repair system (MMR).UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotationARBA annotation
Biological processDNA damage, DNA repairUniRule annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA mismatch repair proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSH6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39432 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Saimiriinae › Saimiri ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 153PWWPInterPro annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 85DisorderedSequence analysisAdd BLAST85
Regioni194 – 362DisorderedSequence analysisAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi246 – 276PolyampholyteSequence analysisAdd BLAST31
Compositional biasi325 – 354PolarSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075024

Database of Orthologous Groups

More...OrthoDBi		138168at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.420.110, 1 hit
3.40.1170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007695, DNA_mismatch_repair_MutS-lik_N
IPR017261, DNA_mismatch_repair_MutS/MSH
IPR000432, DNA_mismatch_repair_MutS_C
IPR007861, DNA_mismatch_repair_MutS_clamp
IPR007696, DNA_mismatch_repair_MutS_core
IPR016151, DNA_mismatch_repair_MutS_N
IPR036187, DNA_mismatch_repair_MutS_sf
IPR007860, DNA_mmatch_repair_MutS_con_dom
IPR036678, MutS_con_dom_sf
IPR027417, P-loop_NTPase
IPR000313, PWWP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01624, MutS_I, 1 hit
PF05188, MutS_II, 1 hit
PF05192, MutS_III, 1 hit
PF05190, MutS_IV, 1 hit
PF00488, MutS_V, 1 hit
PF00855, PWWP, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037677, DNA_mis_repair_Msh6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
SSF55271, SSF55271, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50812, PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6S4G8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQSTLYSF FPKSPALSDA NKASARASRE GGRAAAATRA SPPGEDAAWS 
        60         70         80         90        100
EAGPGPRPLA RSASPPKAKN LNGGLRRSAA TAAPTSCDFS PGDLVWAKME 
       110        120        130        140        150
GYPWWPCLVY NHPFDGTFIR EKGKSVRVHV QFFDDSPTRG WVSKRLLKPY 
       160        170        180        190        200
TGSKSKEAQK GGHFYSAKPE ILRAMQRADE ALNKDKIKRL ELAVCDEPSE 
       210        220        230        240        250
PEEEEEMEVG TTYVTDKSEE DNEIESEEEV QPKTQGSRRS SRQIKKRRVI 
       260        270        280        290        300
SDSESDIGGS DVEFKPDTKE EGSSDEISSG VGDSESEGLN SPVKVARKRK 
       310        320        330        340        350
RMVTGNGSLK RKSSRKEAPS ATKRAIGISS ETKNTLSAFS APQNSESQAH 
       360        370        380        390        400
VSGGGDDSSR PPVWYHETLE WLKEEKRRDE HRRRPDHPDF DGSTLYVPED 
       410        420        430        440        450
FLNSCTPGMR KWWQIKSQNF DLVICYKVGK FYELYHMDAL IGVSELGLVF 
       460        470        480        490        500
MKGNWAHSGF PEIAFGRYSD SLVQKGYKVA RVEQTETPEM MEARCRKMAH 
       510        520        530        540        550
ISKYDRVVRR EICRIITKGT QTYSVLEGDP SENYSKYLLS LKEKEEDSSG 
       560        570        580        590        600
HIRAYGVCFV DTSLGKFFIG QFSDDRHCSR FRTLVAHYPP VQVLFEKGNL 
       610        620        630        640        650
SKETKTILKS SLSSSLQEGL IPGSQFWDAS KTLRTLLEEG YFREKLSDDI 
       660        670        680        690        700
GVMLPQVLKG MTSESDSIGL TPGERSELAL SALGGCVFYL KKCLIDQELL 
       710        720        730        740        750
SMANFEEYIP LDSDTVSTTR SGAVFTKAYQ RMVLDAVTLN NLEIFLNGTN 
       760        770        780        790        800
GSAEGTLLER VDTCHTPFGK RLLKQWLCAP LCSPYAINDR LDAIEDLMAV 
       810        820        830        840        850
PDKISEVVEL LKKLPDLERL LSKIHNVGSP LKSQNHPDSR AIMYEETTYS 
       860        870        880        890        900
KKKIIDFLSA LEGFKVMCKI IGIMEEVVDG FKSKILKQVI SLQTKNPEGR 
       910        920        930        940        950
FPDLTVELNR WDTAFDHEKA RKTGLITPKA GFDSDYDQAL ADIRENEQSL 
       960        970        980        990       1000
LEYLEKQRNR IGCRTIVYWG IGRNRYQLEI PENFTTRNLP EEYELKSTKK 
      1010       1020       1030       1040       1050
GCKRYWTKTI EKKLANLINA EERRDVSLKD CMRRLFYNFD KNYKDWQSAV 
      1060       1070       1080       1090       1100
ECIAVLDVLL CLADYSRGGD GPMCRPVILL PEDTAPFLEL KGSRHPCITK 
      1110       1120       1130       1140       1150
TFFGDDFIPN DILIGCEEEE ENGKAYCVLV TGPNMGGKST LMRQAGLLVV 
      1160       1170       1180       1190       1200
MAQMGCYVPA EVCRLTPIDR VFTRLGASDR IMSGESTFFV ELSETASILS 
      1210       1220       1230       1240       1250
HATAHSLVLV DELGRGTATF DGTAIANAVV KELAETIKCR TLFSTHYHSL 
      1260       1270       1280       1290       1300
VEDYSQNVAV RLGHMACMVE NECEDPSQET ITFLYKFIKG ACPKSYGFNA 
      1310       1320       1330       1340       1350
ARLANLPEEV IQKGHRKARE FEKMNQSLRL FREVCLASER STVDAEAVHK 

LLTLIKEL
Length:1,358
Mass (Da):152,472
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DF83DAFE8C25401
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6S4I6A0A2K6S4I6_SAIBB
DNA mismatch repair protein
MSH6
1,228Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2K6S4J1A0A2K6S4J1_SAIBB
MutS homolog 6
MSH6
1,070Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_003922807.1, XM_003922758.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSSBOT00000013102; ENSSBOP00000002276; ENSSBOG00000011609

Database of genes from NCBI RefSeq genomes

More...GeneIDi		101039649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sbq:101039649

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003922807.1, XM_003922758.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSSBOT00000013102; ENSSBOP00000002276; ENSSBOG00000011609
GeneIDi101039649
KEGGisbq:101039649

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2956

Phylogenomic databases

GeneTreeiENSGT00550000075024
OrthoDBi138168at2759

Family and domain databases

Gene3Di3.30.420.110, 1 hit
3.40.1170.10, 1 hit
InterProiView protein in InterPro
IPR007695, DNA_mismatch_repair_MutS-lik_N
IPR017261, DNA_mismatch_repair_MutS/MSH
IPR000432, DNA_mismatch_repair_MutS_C
IPR007861, DNA_mismatch_repair_MutS_clamp
IPR007696, DNA_mismatch_repair_MutS_core
IPR016151, DNA_mismatch_repair_MutS_N
IPR036187, DNA_mismatch_repair_MutS_sf
IPR007860, DNA_mmatch_repair_MutS_con_dom
IPR036678, MutS_con_dom_sf
IPR027417, P-loop_NTPase
IPR000313, PWWP_dom
PfamiView protein in Pfam
PF01624, MutS_I, 1 hit
PF05188, MutS_II, 1 hit
PF05192, MutS_III, 1 hit
PF05190, MutS_IV, 1 hit
PF00488, MutS_V, 1 hit
PF00855, PWWP, 1 hit
PIRSFiPIRSF037677, DNA_mis_repair_Msh6, 1 hit
SMARTiView protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00293, PWWP, 1 hit
SUPFAMiSSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
SSF55271, SSF55271, 1 hit
PROSITEiView protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50812, PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6S4G8_SAIBB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6S4G8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: February 10, 2021
This is version 15 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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