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Protein
Submitted name:

ATP binding cassette subfamily B member 4

Gene

ABCB4

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi474 – 481ATPPROSITE-ProRule annotation8
Nucleotide bindingi1114 – 1121ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP binding cassette subfamily B member 4Imported
Gene namesi
Name:ABCB4Imported
OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)Imported
Taxonomic identifieri39432 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri
Proteomesi
  • UP000233220 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei100 – 123HelicalSequence analysisAdd BLAST24
Transmembranei162 – 187HelicalSequence analysisAdd BLAST26
Transmembranei237 – 256HelicalSequence analysisAdd BLAST20
Transmembranei262 – 280HelicalSequence analysisAdd BLAST19
Transmembranei342 – 363HelicalSequence analysisAdd BLAST22
Transmembranei375 – 396HelicalSequence analysisAdd BLAST22
Transmembranei797 – 816HelicalSequence analysisAdd BLAST20
Transmembranei903 – 924HelicalSequence analysisAdd BLAST22
Transmembranei979 – 998HelicalSequence analysisAdd BLAST20
Transmembranei1018 – 1039HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 404ABC transmembrane type-1InterPro annotationAdd BLAST301
Domaini439 – 675ABC transporterInterPro annotationAdd BLAST237
Domaini757 – 1044ABC transmembrane type-1InterPro annotationAdd BLAST288
Domaini1079 – 1317ABC transporterInterPro annotationAdd BLAST239

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili917 – 937Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000062896

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030275 MDR3
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PTHR24221:SF241 PTHR24221:SF241, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A2K6S200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGAGREWRD PHPESLGSAT RAPGGKPRAG AGALGPEAVV SPQAEMDLEA
60 70 80 90 100
ARNGTARRRG REEGDFELGS SSNQNRKKMK KVKLIGPLTL FRYSDWQDKL
110 120 130 140 150
FMSLGTIMAI AHGSGLPIMM IVFGEMTDKF VDTSGNFSFP VNFSLSLLNL
160 170 180 190 200
GKILEEEMTR YAYYYSGLGA GVLVAAYIQV SFWTLAAGRQ IRKIRQKFFH
210 220 230 240 250
AILRQEIGWF DINDTTELNT RLTDDISKIS EGIGDKVGMF FQAVATFFAG
260 270 280 290 300
FIVGFIRGWK LTLVIMAISP ILGLSAAVWA KILSAFSDKE LAAYAKAGAV
310 320 330 340 350
AEETLGAIRT VIAFGGQNKE LERYQKHLEN AKKIGIKKAI SANISMGIAF
360 370 380 390 400
LLIYASYALA FWYGSTLVIS KEYTIGNAMT VFFSILIGAF SVGQAAPCID
410 420 430 440 450
AFANARGAAY VIFDIIDNNP KIDSFSERGQ KPDSITGNLE FNDVHFSYPS
460 470 480 490 500
RANVKILKGL NLKVQSGQTV ALVGSSGCGK STMVQLIQRL YDPDEGTINI
510 520 530 540 550
DGQDIRNFNV SYLREIIGVV NQEPVLFSTT IAENIRYGRG NVTMDEIKKA
560 570 580 590 600
VKEANAYEFI MKLPQKFDTL VGERGAQLSG GQKQRIAIAR ALVRNPKILL
610 620 630 640 650
LDEATSALDT ESEAEVQAAL DKAREGRTTI VIAHRLSTVR NADVIAGFED
660 670 680 690 700
GVIVEQGSHS ELMKKEGVYF KLVNMQTSGS QIQSEEFELN DEKAATGMAP
710 720 730 740 750
NGWKSRLFRH STQKNLKNSR IGQNILDVEI DGLEANVPPV SFLKVLKLNK
760 770 780 790 800
TEWPYFVVGT VCAITNGGLQ PAFSVIFSEM IAIFGPGDDA VKQQKCNMFS
810 820 830 840 850
LLFLCLGIIS FFTFFLQGFT FGKAGEILTT RLRSMAFKAM LRQDISWFDD
860 870 880 890 900
HKNSTGALST RLATDAAQVQ GATGTRLALI AQNVANLGTG IIISFIYGWQ
910 920 930 940 950
LTLLLLSVVP IIAVSGIVEM KLLAGNAKRD KKELEAAGKI ATEAIENIRT
960 970 980 990 1000
VVSLTQERKF ESMYVEKLYG PYRNSVRKAH IYGITFSISQ AFMYFSYAGC
1010 1020 1030 1040 1050
FRFGAYLIVN GHMRFRDVIL VFSAIVFGAV ALGHASSFAP DYAKAKLSAA
1060 1070 1080 1090 1100
HLFMLFERQP LIDSYSEEGL KPDKFEGNVT FSEVMFNYPT RPNVPVLQGL
1110 1120 1130 1140 1150
SLEVKKGQTL ALVGSSGCGK STVVQLLERF YDPLAGTVLL DGQEAKKLNV
1160 1170 1180 1190 1200
QWLRAQLGIV SQEPILFDCS IAENIAYGDN SRVVSQDEIV SAAKAANIHH
1210 1220 1230 1240 1250
FIETLPHKYK TRVGDKGTQL SGGQKQRIAI ARALIRQPQI LLLDEATSAL
1260 1270 1280 1290 1300
DTESEKVVQE ALDKAREGRT CIVIAHRLST IQNADLIVVF QNGRIKEHGT
1310 1320
HQQLLAQKGI YFSMVSVQAG TQNL
Length:1,324
Mass (Da):145,399
Last modified:March 28, 2018 - v1
Checksum:i6A86EF0D746887C2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2K6S218A0A2K6S218_SAIBB
ATP binding cassette subfamily B me...
ABCB4
1,279Annotation score:
A0A2K6S1J8A0A2K6S1J8_SAIBB
ATP binding cassette subfamily B me...
ABCB4
1,279Annotation score:
A0A2K6S222A0A2K6S222_SAIBB
ATP binding cassette subfamily B me...
ABCB4
1,276Annotation score:
A0A2K6S240A0A2K6S240_SAIBB
ATP binding cassette subfamily B me...
ABCB4
1,232Annotation score:
A0A2K6S1K2A0A2K6S1K2_SAIBB
ATP binding cassette subfamily B me...
ABCB4
1,276Annotation score:

Genome annotation databases

EnsembliENSSBOT00000007763; ENSSBOP00000001414; ENSSBOG00000004485

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSBOT00000007763; ENSSBOP00000001414; ENSSBOG00000004485

Phylogenomic databases

GeneTreeiENSGT00530000062896

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR030275 MDR3
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PTHR24221:SF241 PTHR24221:SF241, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2K6S200_SAIBB
AccessioniPrimary (citable) accession number: A0A2K6S200
Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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