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UniProtKB - A0A2K6RLS6 (A0A2K6RLS6_RHIRO)
Protein
Ceramidase
Gene
ASAH1
Organism
Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 159 | NucleophileUniRule annotation | 1 |
GO - Molecular functioni
- ceramidase activity Source: UniProtKB-EC
- fatty acid amide hydrolase activity Source: InterPro
- N-acylsphingosine amidohydrolase activity Source: UniProtKB-EC
GO - Biological processi
- ceramide biosynthetic process Source: Ensembl
- ceramide catabolic process Source: Ensembl
- fatty acid metabolic process Source: InterPro
- keratinocyte differentiation Source: Ensembl
- regulation of steroid biosynthetic process Source: Ensembl
- sphingosine biosynthetic process Source: Ensembl
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Biological process | Lipid metabolismUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ASAH1Imported |
Organismi | Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)Imported |
Taxonomic identifieri | 61622 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Colobinae › Rhinopithecus |
Proteomesi |
|
Subcellular locationi
Lysosome
- Lysosome UniRule annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Lysosome
- lysosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
LysosomeUniRule annotationInteractioni
Subunit structurei
Heterodimer.
UniRule annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 122 | NAAA-betaInterPro annotationAdd BLAST | 62 | |
Domaini | 159 – 400 | CBAHInterPro annotationAdd BLAST | 242 |
Sequence similaritiesi
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00530000063548 |
Family and domain databases
InterProi | View protein in InterPro IPR016699, Acid_ceramidase-like IPR029130, Acid_ceramidase_N IPR029132, CBAH/NAAA_C |
Pfami | View protein in Pfam PF02275, CBAH, 1 hit PF15508, NAAA-beta, 1 hit |
PIRSFi | PIRSF017632, Acid_ceramidase-like, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
A0A2K6RLS6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGRVWLGDK ARGSHLTSSP SLSALFTEAS ILGFGSSAVK AQWTEDCRKS
60 70 80 90 100
SYPPSGPTYR GPAPWYTINL DLPPYKRWHE LMVDKAPMLK VIVNSLKNMV
110 120 130 140 150
NTFVPSGKIM QIVDEKLPGL LGNFPGPFEE EMKGIAAVTD IPLGEIISYN
160 170 180 190 200
IFYEFFTICT SIVAEDRKGH LIHGRNMDFG VFLGWNINND TWVITEELKP
210 220 230 240 250
LTVNLDFQRN NKTVFKASSF AGYVGMLTGF KPGLFSLTLN ERFSVNGGYL
260 270 280 290 300
GILEWILGKK DAMWIGFLTR TVLENSTSYE EAKNTLTKTK ILAPAYFILG
310 320 330 340 350
GNQSGEGCVI TRDRKESLDV YELDAKHGRW YVVQTNYDRW KNPFFLDDRR
360 370 380 390 400
TPAKMCLNHT TQENISFETM YDVLSTKPVL NKLTVFTTLI DVTKDQFETY
410
IRDCPDPCIG W
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2K6RLQ9 | A0A2K6RLQ9_RHIRO | Ceramidase | ASAH1 | 395 | Annotation score: | ||
A0A2K6RLS5 | A0A2K6RLS5_RHIRO | Ceramidase | ASAH1 | 389 | Annotation score: | ||
A0A2K6RLU2 | A0A2K6RLU2_RHIRO | Ceramidase | ASAH1 | 341 | Annotation score: | ||
A0A2K6RLT1 | A0A2K6RLT1_RHIRO | Ceramidase | ASAH1 | 386 | Annotation score: | ||
A0A2K6RLU0 | A0A2K6RLU0_RHIRO | NAAA-beta domain-containing protein | ASAH1 | 174 | Annotation score: | ||
A0A2K6RLS9 | A0A2K6RLS9_RHIRO | Uncharacterized protein | ASAH1 | 288 | Annotation score: | ||
A0A2K6RLU7 | A0A2K6RLU7_RHIRO | NAAA-beta domain-containing protein | ASAH1 | 159 | Annotation score: |
Genome annotation databases
Ensembli | ENSRROT00000066482; ENSRROP00000041979; ENSRROG00000044101 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSRROT00000066482; ENSRROP00000041979; ENSRROG00000044101 |
Phylogenomic databases
GeneTreei | ENSGT00530000063548 |
Family and domain databases
InterProi | View protein in InterPro IPR016699, Acid_ceramidase-like IPR029130, Acid_ceramidase_N IPR029132, CBAH/NAAA_C |
Pfami | View protein in Pfam PF02275, CBAH, 1 hit PF15508, NAAA-beta, 1 hit |
PIRSFi | PIRSF017632, Acid_ceramidase-like, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A2K6RLS6_RHIRO | |
Accessioni | A0A2K6RLS6Primary (citable) accession number: A0A2K6RLS6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 28, 2018 |
Last sequence update: | March 28, 2018 | |
Last modified: | April 7, 2021 | |
This is version 18 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |